The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis
- 870 Downloads
The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.
The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle–Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed.
The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27–0.04; p = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38–0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43–0.63; p = 0.71).
This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
KeywordsVitamin D Adipokines C-reactive protein Cytokines Dietary supplements Obesity
MJ and MSM designed the study, searched databases, performed the selection of studies and wrote the manuscript. MSM analysed the data; JW contributed to writing the manuscript and commented on it. MW and PB searched databases and commented on the manuscript. JJ commented on the manuscript. All authors reviewed and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The manuscript does not contain clinical studies or patient data.
- 1.World Health Organization (2015) Obesity and overweight. Fact sheet No. 311 http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 24 January 2015
- 14.Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG et al (2011) Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr 35(3):308–316. doi: 10.1177/0148607110381267 CrossRefGoogle Scholar
- 15.Brock K, Huang WY, Fraser DR, Ke L, Tseng M, Stolzenberg-Solomon R et al (2010) Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J Steroid Biochem Mol Biol 121(1–2):462–466. doi: 10.1016/j.jsbmb.2010.03.091 CrossRefGoogle Scholar
- 17.Nimitphong H, Chanprasertyothin S, Jong-Jaroenprasert W, Ongphiphadhanakul B (2009) The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance. Endocrine 36(2):205–210. doi: 10.1007/s12020-009-9216-9 CrossRefGoogle Scholar
- 18.Dutta D, Mondal SA, Choudhuri S, Maisnam I, Hasanoor Reza AH, Bhattacharya B et al (2014) Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India. Diabetes Res Clin Pract 103(3):e18–e23. doi: 10.1016/j.diabres.2013.12.044 CrossRefGoogle Scholar
- 19.Neyestani TR, Nikooyeh B, Alavi-Majd H, Shariatzadeh N, Kalayi A, Tayebinejad N et al (2012) Improvement of vitamin D status via daily intake of fortified yogurt drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes. J Clin Endocrinol Metab 97(6):2005–2011. doi: 10.1210/jc.2011-3465 CrossRefGoogle Scholar
- 20.Jamka M, Woźniewicz M, Bogdański P, Stelmach-Mardas M (2015) Effect of vitamin D supplementation on inflammatory cytokines, adipokines and C-reactive protein in obese subjects. PROSPERO: CRD4201501641. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015016416. Accessed 4 Feb 2015
- 21.World Health Organization (2004) BMI classification. Global database on body mass index. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. Accessed 2 Jan 2015
- 22.Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2014) The Newcastle–Ottawa Scale (NOS) for Assessing the quality of nonrandomised studies in meta-analyses. http://www.medicine.mcgill.ca/rtamblyn/Readings%5CThe%20Newcastle%20-%20Scale%20for%20assessing%20the%20quality%20of%20nonrandomised%20studies%20in%20meta-analyses.pdf. Accessed 8 June 2015
- 25.de Medeiros Cavalcante IG, Silva AS, Costa MJ, Persuhn DC, Issa CI, de Luna Freire TL et al (2015) Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: vitamin D3 megadose reduces inflammatory markers. Exp Gerontol 66:10–16. doi: 10.1016/j.exger.2015.03.011 CrossRefGoogle Scholar
- 26.Duggan C, de Dieu Tapsoba J, Mason C, Imayama I, Korde L, Wang CY et al (2015) Effect of vitamin D3 supplementation in combination with weight loss on inflammatory biomarkers in postmenopausal women: a randomized controlled trial. Cancer Prev Res (Phila) 8(7):628–635. doi: 10.1158/1940-6207.CAPR-14-0449 CrossRefGoogle Scholar
- 28.Chandler PD, Scott JB, Drake BF, Ng K, Manson JE, Rifai N et al (2014) Impact of vitamin D supplementation on inflammatory markers in African Americans: results of a four-arm, randomized, placebo-controlled trial. Cancer Prev Res (Phila) 7(2):218–225. doi: 10.1158/1940-6207.CAPR-13-0338-T CrossRefGoogle Scholar
- 30.Nader NS, Aguirre Castaneda R, Wallace J, Singh R, Weaver A, Kumar S (2014) Effect of vitamin D3 supplementation on serum 25(OH)D, lipids and markers of insulin resistance in obese adolescents: a prospective, randomized, placebo-controlled pilot trial. Horm Res Paediatr 82(2):107–112. doi: 10.1159/000362449 CrossRefGoogle Scholar
- 31.Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen SB, Richelsen B (2013) Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels: results from a randomized trial. Eur J Intern Med 24(7):644–649. doi: 10.1016/j.ejim.2013.03.005 CrossRefGoogle Scholar
- 35.von Hurst PR, Stonehouse W, Coad J (2010) Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient: a randomised, placebo-controlled trial. Br J Nutr 103(4):549–555. doi: 10.1017/S0007114509992017 CrossRefGoogle Scholar
- 38.International Diabetes Federation (2006) The IDF consensus worldwide definition of the metabolic syndrome. http://www.idf.org/webdata/docs/IDF_Meta_def_final.pdf. Accessed 9 Mar 2015
- 41.Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H et al (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17(1):4–12Google Scholar
- 43.Colin EM, Asmawidjaja PS, van Hamburg JP, Mus AM, van Driel M, Hazes JM et al (2010) 1,25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 62(1):132–142. doi: 10.1002/art.25043 CrossRefGoogle Scholar
- 48.Malek HA, Shata A (2014) Effect of a high dose of vitamin D on a rabbit model of atherosclerosis. Int J Immunopathol Pharmacol 27(2):195–201Google Scholar
- 58.Caballero AE, Bousquet-Santos K, Robles-Osorio L, Montagnani V, Soodini G, Porramatikul S et al (2008) Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance. Diabetes Care 31(3):576–582CrossRefGoogle Scholar