Iodine status in healthy pregnant women in Korea: a first report
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Proper iodine intake is important during pregnancy for both fetal neurodevelopment and maternal thyroid function. Korea is known as a high iodine intake area. However, there are no data regarding iodine status in pregnant Korean women. Therefore, we evaluated the iodine status of pregnant women in Korea by measuring urine iodine concentration.
This study had an observational, prospective design. We enrolled 344 healthy pregnant women who visited Samsung Medical Center in Korea for a routine antenatal checkup between April 2012 and September 2013. We measured iodine and creatinine concentration (Cr) in spot urine samples and TSH level in serum at the time of enrollment.
The median urinary iodine concentration (UIC) and UIC adjusted by Cr were 427.3 μg/L and 447.9 μg/gCr, respectively. There was no difference in median UIC according to trimester of pregnancy (P value = 0.953). Serum TSH level was not different according to UIC level when subjects were grouped according to WHO iodine recommendations (P value = 0.401).
The median UIC of healthy pregnant women in Korea was 427.3 μg/L and 447.9 μg/gCr, which are more than adequate according to WHO criteria. Considering the wide range of UIC, we recommend active education about adequate iodine intake during pregnancy in areas where iodine intake is more than adequate according to WHO criteria.
KeywordsIodine Urine Pregnancy Women Korea
Conflict of interest
The authors have nothing to declare about this study.
- 1.Glinoer D, De Nayer P, Delange F, Lemone M, Toppet V, Spehl M, Grun JP, Kinthaert J, Lejeune B (1995) A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects. J Clin Endocrinol Metab 80:258–269Google Scholar
- 3.Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, Chen ZP (2005) The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr 14:32–42Google Scholar
- 8.World Health Organization (2007) International council for the control of iodine deficiency disorders 2007 Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. World Health Organization, GenevaGoogle Scholar
- 9.De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J, Rovet J, Sullivan S (2012) Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97:2543–2565CrossRefGoogle Scholar
- 11.Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W (2011) Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 21:1081–1125CrossRefGoogle Scholar
- 14.Statistics Korea (2010) Population, households and housing units by census in Korea (2010). Statistics Korea Publishing KosisWeb. http://kosis.kr/eng/statisticsList/statisticsList_01List.jsp?vwcd=MT_ETITLE&parmTabId=M_01_01#SubCont. Assessed 7 January 2015
- 18.Orito Y, Oku H, Kubota S, Amino N, Shimogaki K, Hata M, Manki K, Tanaka Y, Sugino S, Ueta M, Kawakita K, Nunotani T, Tatsumi N, Ichihara K, Miyauchi A, Miyake M (2009) Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development. J Clin Endocrinol Metab 94:1683–1688CrossRefGoogle Scholar
- 22.Ainy E, Ordookhani A, Hedayati M, Azizi F (2007) Assessment of intertrimester and seasonal variations of urinary iodine concentration during pregnancy in an iodine-replete area. Clin Endocrinol (Oxf) 67:577–581Google Scholar
- 31.Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab 87:489–499CrossRefGoogle Scholar
- 33.Pennington JA (1990) A review of iodine toxicity reports. J Am Diet Assoc 90:1571–1581Google Scholar
- 34.Wolff J, Chaikoff IL (1948) Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 174:555–564Google Scholar