Higher intake of carotenoid is associated with a lower risk of colorectal cancer in Chinese adults: a case–control study
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The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults.
From July 2010 to October 2013, 845 eligible colorectal cancer cases and 845 frequency-matched controls (age and sex) completed in-person interviews. A validated food frequency questionnaire was used to estimate dietary intake. Multivariate logistical regression models were used to calculate the odds ratio (OR) and 95 % confidence intervals (95 % CIs) of colorectal cancer risk after adjusting for various confounders.
A strong inverse association was found between β-cryptoxanthin intake and colorectal cancer risk. Compared with the lowest quartile, the highest quartile intake showed a risk reduction of 77 % (OR 0.23, 95 % CI 0.17–0.33, P trend < 0.01) after adjustment for various confounding variables. The inverse associations were also observed for α-carotene (OR 0.50, 95 % CI 0.37–0.68, P trend < 0.01), β-carotene (OR 0.67, 95 % CI 0.49–0.91, P trend < 0.01), and lycopene (OR 0.51, 95 % CI 0.37–0.70, P trend < 0.01). There was no statistically significant association between lutein/zeaxanthin intake and colorectal cancer risk. These findings were consistent across cancer site, sources of controls, and smoking status. The inverse associations between dietary α-carotene, β-cryptoxanthin, and lycopene intake and colorectal cancer risk were found in both males and females, while inverse associations between β-carotene intake and colorectal cancer risk were only observed in males.
Consumption of α-carotene, β-carotene, β-cryptoxanthin, and lycopene was inversely associated with colorectal cancer risk. No significant association was found between lutein/zeaxanthin intake and colorectal cancer risk.
KeywordsCarotenoid Colorectal cancer Case–control study China
This study was jointly supported by the Sun Yat-sen University Hundred Talents Program (51000-3181301) and Danone Nutrition Research and Education Foundation (No: DIC2011-03). The funders had no role in the design, analysis, or writing of this article. We gratefully acknowledge the cooperation of the study participants; without them the study would not have been possible.
Conflict of interest
The authors declare no conflict of interest.
- 1.Wu F, Lin G, Zhang J (2012) An overview of cancer incidence and trend in China. China Cancer 2:81–85Google Scholar
- 6.Britton G (1995) Structure and properties of carotenoids in relation to function. FASEB J 9:1551–1558Google Scholar
- 9.Chew BP, Park JS (2004) Carotenoid action on the immune response. J Nutr 134:257S–261SGoogle Scholar
- 12.Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G (1990) A case–control study of diet and rectal cancer in western New York. Am J Epidemiol 131:612–624Google Scholar
- 20.Chiu BC, Ji BT, Dai Q, Gridley G, McLaughlin JK, Gao YT, Fraumeni JJ, Chow WH (2003) Dietary factors and risk of colon cancer in Shanghai, China. Cancer Epidemiol Biomark Prev 12:201–208Google Scholar
- 22.Wang LD (2005) The dietary and nutritional status of Chinese population: 2002 National Nutrition Survey. People’s Medical Publishing House, BeijingGoogle Scholar
- 26.Chen C, Lu FC (2004) The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci 17(Suppl):1–36Google Scholar
- 27.Zhang CX, Ho SC (2009) Validity and reproducibility of a food frequency Questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 18:240–250Google Scholar
- 28.Exler JKJ (2012) USDA national nutrient database for standard reference,release 25. http://www.ars.usda.gov/Services/docs.htm?docid=8964
- 29.Yang YX, Wang GY, Pan XC (2002) China food composition. Peking University Medical Press, BeijingGoogle Scholar
- 31.Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl): 1220S–1228S, 1229S–1231SGoogle Scholar
- 34.Slattery ML, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD (2000) Carotenoids and colon cancer. Am J Clin Nutr 71:575–582Google Scholar
- 44.Gomes S, Torres AG, Godoy R, Pacheco S, Carvalho J, Nutti M (2013) Effects of boiling and frying on the bioaccessibility of beta-carotene in yellow-fleshed cassava roots (Manihot esculenta Crantz cv. BRS Jari). Food Nutr Bull 34:65–74Google Scholar
- 45.van Het HK, West CE, Weststrate JA, Hautvast JG (2000) Dietary factors that affect the bioavailability of carotenoids. J Nutr 130:503–506Google Scholar
- 47.Potter JD, McMichael AJ (1986) Diet and cancer of the colon and rectum: a case–control study. J Natl Cancer Inst 76:557–569Google Scholar
- 50.Macfarlane GT, Macfarlane S (1997) Human colonic microbiota: ecology, physiology and metabolic potential of intestinal bacteria. Scand J Gastroenterol Suppl 222:3–9Google Scholar
- 53.Wan D, Chen G, Pan Z (2001) Dynamic analysis of hospitalized colorectal cancer patients in 35 years (1964–1999). Guangdong Med J 07:557–558Google Scholar
- 54.Xu A, Jiang B (2006) The trend of clinical characteristics of colorectal cancer during the past 20 years in Guangdong province. Natl Med J China 04:272–275Google Scholar
- 55.Dai Z, Zheng RS, Zou XN, Zhang SW, Zeng HM, Li N, Chen WQ (2012) Analysis and prediction of colorectal cancer incidence trend in China. China J Prev Med 46:598–603Google Scholar