European Journal of Nutrition

, Volume 54, Issue 4, pp 609–617 | Cite as

Dietary patterns and breast cancer: a case–control study in women

  • Niki Mourouti
  • Christos Papavagelis
  • Petrini Plytzanopoulou
  • Meropi Kontogianni
  • Tonia Vassilakou
  • Nikolaos Malamos
  • Athena Linos
  • Demosthenes Panagiotakos
Original Contribution

Abstract

Purpose

Since dietary habits have been associated with breast cancer, the tested research hypothesis was the associations between food patterns, as derived through multivariate methods, and breast cancer.

Methods

In a case–control study, Two-hundred and fifty consecutive, newly diagnosed breast cancer female patients (56 ± 12 years) and 250 one-to-one age-matched, healthy controls were studied. A standardized, validated questionnaire assessing various socio-demographic, clinical, lifestyle, and dietary characteristics was applied through face-to-face interviews. Factor analysis, with principal components method, was applied to extract dietary patterns from 86 foods or food groups consumption reported by the controls.

Results

Three components were derived explaining 43 % of the total variation in consumption. Component 1 was characterized by the consumption of potatoes, red meat and its products, poultry and white meat, dairy products, use of margarine/butter in cooking or at the table, consumption of sausages, fried food as well as grilled meat or fish; component 2 was characterized by the consumption of whole grains, fruits, and vegetables; and component 3 was characterized by olive oil and fish consumption. After adjusting for various confounders, components 2 and 3 were favorably associated with the absence of having breast cancer [odds ratio (OR) 0.60, 95 % CI 0.47–0.75 and OR 0.81, 95 % CI 0.66–0.99, respectively], while component 1 was not significantly associated with the disease.

Conclusions

Adherence to healthy dietary patterns (including whole grains, fruits, and vegetables, olive oil, and fish) seems to be favorable in not having breast cancer, among middle-aged women.

Keywords

Breast cancer Dietary patterns Factor analysis 

Notes

Acknowledgments

The authors would like to thank all the participants of the study because without their contribution this project would never been done and also would like to thank the Directors of the clinics of the involved hospitals: Gerasimos Aravantinos, Epaminondas Samantas, Evangelos Filopoulos, and the field investigators of the study: Aikaterini Manousou, Vassiliki Markasioti, Aikaterini Kakou, Fotini-Maria Mpalli, Nikolaos Soupos, Zoe Tsakalou, Maria Mitsou, Artemisia Tsakla, Iro Karapapa, Maria Somaraki, Athanasios Tektonidis, Athanasia Laina, and Aggeliki Siolavou.

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

References

  1. 1.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90CrossRefGoogle Scholar
  2. 2.
    Michels KB, Mohllajee AP, Roset-Bahmanyar E, Beehler GP, Moysich KB (2007) Diet and breast cancer: a review of the prospective observational studies. Cancer 109:2712–2749CrossRefGoogle Scholar
  3. 3.
    Thomson CA (2012) Diet and breast cancer: understanding risks and benefits. Nutr Clin Pract 27:636–650CrossRefGoogle Scholar
  4. 4.
    WCRF/AICR (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, WashingtonGoogle Scholar
  5. 5.
    Zhong X, Zhang C (2012) Soy food intake and breast cancer risk: a meta-analysis. Wei Sheng Yan Jiu 41:670–676Google Scholar
  6. 6.
    Dong JY, Zhang L, He K, Qin LQ (2011) Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Breast Cancer Res Treat 127:23–31CrossRefGoogle Scholar
  7. 7.
    Jacques PF, Tucker KL (2001) Are dietary patterns useful for understanding the role of diet in chronic disease? Am J Clin Nutr 73:1–2Google Scholar
  8. 8.
    Trichopoulos D, Lagiou P (2001) Dietary patterns and mortality. Br J Nutr 85:133–134CrossRefGoogle Scholar
  9. 9.
    Alberti A, Fruttini D, Fidanza F (2009) The Mediterranean Adequacy Index: further confirming results of validity. Nutr Metab Cardiovasc Dis 19:61–66CrossRefGoogle Scholar
  10. 10.
    Mitrou PN, Kipnis V, Thiebaut AC et al (2007) Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med 167:2461–2468CrossRefGoogle Scholar
  11. 11.
    Panagiotakos DB, Pitsavos C, Stefanadis C (2006) Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 16:559–568CrossRefGoogle Scholar
  12. 12.
    Trichopoulou A, Bamia C, Trichopoulos D (2005) Mediterranean diet and survival among patients with coronary heart disease in Greece. Arch Intern Med 165:929–935CrossRefGoogle Scholar
  13. 13.
    Kim J-O, Mueller C (1978) Factor analysis: statistical methods and practical issues. Sage, Newbury ParkGoogle Scholar
  14. 14.
    Newby PK, Tucker KL (2004) Empirically derived eating patterns using factor or cluster analysis: a review. Nutr Rev 62:177–203CrossRefGoogle Scholar
  15. 15.
    Mourouti N, Papavagelis C, Psaltopoulou T et al (2013) Aims, design and methods of a case-control study for the assessment of the role of dietary habits, eating behaviors and environmental factors, on the development of breast cancer. Maturitas 74:31–36CrossRefGoogle Scholar
  16. 16.
    Panagiotakos DB, Dimakopoulou K, Katsouyanni K, Bellander T, Grau M et al (2009) Mediterranean diet and inflammatory response in myocardial infarction survivors. Int J Epidemiol 38:856–866CrossRefGoogle Scholar
  17. 17.
    Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C (2007) Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 44:335–340CrossRefGoogle Scholar
  18. 18.
    Craig CL, Marshall AL, Sjostrom M et al (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35:1381–1395CrossRefGoogle Scholar
  19. 19.
    Papathanasiou G, Georgoudis G, Papandreou M et al (2009) Reliability measures of the short International Physical Activity Questionnaire (IPAQ) in Greek young adults. Hell J Cardiol 50:283–294Google Scholar
  20. 20.
    Mardia KV, Kent JT, Bibby JM (1979) Multivariate analysis, 1st edn. Academic Press, New YorkGoogle Scholar
  21. 21.
    Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13:3–9CrossRefGoogle Scholar
  22. 22.
    Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV (2010) Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr 91:1294–1302CrossRefGoogle Scholar
  23. 23.
    Buck K, Vrieling A, Flesch-Janys D, Chang-Claude J (2011) Dietary patterns and the risk of postmenopausal breast cancer in a German case-control study. Cancer Causes Control 22:273–282CrossRefGoogle Scholar
  24. 24.
    Zhang CX, Ho SC, Fu JH, Cheng SZ, Chen YM, Lin FY (2011) Dietary patterns and breast cancer risk among Chinese women. Cancer Causes Control 22:115–124CrossRefGoogle Scholar
  25. 25.
    Hirose K, Matsuo K, Iwata H, Tajima K (2007) Dietary patterns and the risk of breast cancer in Japanese women. Cancer Sci 98:1431–1438CrossRefGoogle Scholar
  26. 26.
    Link LB, Canchola AJ, Bernstein L et al (2013) Dietary patterns and breast cancer risk in the California Teachers Study cohort. Am J Clin Nutr 98:1524–1532CrossRefGoogle Scholar
  27. 27.
    Baglietto L, Krishnan K, Severi G et al (2011) Dietary patterns and risk of breast cancer. Br J Cancer 104:524–531CrossRefGoogle Scholar
  28. 28.
    Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2:427–442CrossRefGoogle Scholar
  29. 29.
    Steinmetz KA, Potter JD (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96:1027–1039CrossRefGoogle Scholar
  30. 30.
    Deschasaux M, Zelek L, Pouchieu C et al (2013) Prospective association between dietary fiber intake and breast cancer risk. PLoS ONE 8:e79718CrossRefGoogle Scholar
  31. 31.
    Escrich E, Solanas M, Moral R, Escrich R (2011) Modulatory effects and molecular mechanisms of olive oil and other dietary lipids in breast cancer. Curr Pharm Des 17:813–830CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Niki Mourouti
    • 1
  • Christos Papavagelis
    • 1
  • Petrini Plytzanopoulou
    • 2
  • Meropi Kontogianni
    • 1
  • Tonia Vassilakou
    • 2
  • Nikolaos Malamos
    • 3
  • Athena Linos
    • 4
  • Demosthenes Panagiotakos
    • 1
  1. 1.Department of Nutrition and Dietetics, School of Health Science and EducationHarokopio UniversityAthensGreece
  2. 2.Department of Nutrition and BiochemistryNational School of Public HealthAthensGreece
  3. 3.Pathology-Oncology DepartmentGeneral Hospital “Elena Venizelos”AthensGreece
  4. 4.Department of Hygiene, Epidemiology and Medical Statistics, School of MedicineUniversity of AthensAthensGreece

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