Metabolic syndrome in Spanish adolescents and its association with birth weight, breastfeeding duration, maternal smoking, and maternal obesity: a cross-sectional study
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The metabolic syndrome (MetS) in adolescents is a growing problem. The objectives were to verify the association among early predictors such as birth weight, breastfeeding, maternal weight status, smoking during pregnancy, and the development of MetS.
A cross-sectional study was performed of 976 children and adolescents, 10–15 years of age, at schools in the provinces of Granada and Almeria (Spain). For this purpose, we analyzed the physical characteristics as well as the biochemical markers of the participants with a view to ascertaining the prevalence of the MetS. Relevant data were also extracted from the clinical histories of their mothers.
It was found that 3.85 % of the female subjects and 5.38 % of the male subjects in the sample population suffered from MetS. In both sexes, there was an association between birth weight and positive MetS diagnosis (OR 1.27). For both males and females, there was an inverse association between the length of time that they had been breastfed and positive MetS diagnosis (OR1–3 months 3.16; OR4–6 months 1.70; OR>6 months 0.13). There was also a significant association between maternal weight (ORoverweight 30.79; ORobesity 49.36) and cigarette consumption during pregnancy (OR 1.47) and the subsequent development of MetS in the children of these mothers.
Those subjects born with a higher than average birth weight had a greater risk of developing MetS in childhood and adolescence. Breastfeeding children for longer than 6 months protected them from MetS in their early years as well as in their teens. Other risk factors for MetS were maternal smoking during pregnancy as well as maternal overweight and obesity.
KeywordsMetabolic syndrome Adolescents Related factors
Conflict of interest
The authors declare they have no competing interests.
- 2.Bahar A, Hosseini Esfahani F, Asghari Jafarabadi M, Mehrabi Y, Azizi F (2013) The structure of metabolic syndrome components across follow-up survey from childhood to adolescence. Int J Endocrinol Metab 11:16–22Google Scholar
- 3.Montero-Alonso MA, González-Jiménez E (2013) Valoración del estado nutricional, resistencia insulínica y riesgo cardiovascular en una población de adolescentes de la ciudades de Granada y Almería. Nutr Hosp 28:802–806Google Scholar
- 5.Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R, Schnedl WJ, Reininghaus E, Paulmichl K, Weghuber D, Fuchs D (2013) Obesity-related dysregulation of the Tryptophan–Kynurenine metabolism: role of age and parameters of the metabolic syndrome. Obesity (Silver Spring) 22:195–201Google Scholar
- 10.Ahmadi A, Gharipour M, Nouri F, Sarrafzadegan N (2013) Metabolic syndrome in Iranian youths: a population-based study on junior and high schools students in rural and urban areas. J Diabetes Res 2013:738485Google Scholar
- 15.Stuebe A (2009) The risks of not breastfeeding for mothers and infants. Rev Obstet Gynecol 2:222–231Google Scholar
- 17.Oddy WH (2012) Infant feeding and obesity risk in the child. Breastfeed Rev 20:7–12Google Scholar
- 20.Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA, Srinivasan S, Wallinga D, White MF, Walker VR, Thayer KA, Holloway AC (2013) Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect 121:170–180Google Scholar
- 21.Sánchez-Muniz FJ, Gesteiro E, Espárrago Rodilla M, Rodríguez Bernal B, Bastida S (2013) Maternal nutrition during pregnancy conditions the fetal pancreas development, hormonal status and diabetes mellitus and metabolic syndrome biomarkers at birth. Nutr Hosp 28:250–274Google Scholar
- 26.Siri WE (1961) Body composition from fluid spaces and density: analysis of methods. In: Brozeck J, Henschel A (eds) Techniques for measuring body composition. National Acad Sci National Res Council, WashingtonGoogle Scholar
- 28.Aguayo Calcena AA (2011) Prevalencia del síndrome metabólico en una población de niños obesos en el País Vasco, su relación con la resistencia a la insulina, las adipoquinas y ghrelina. (PhD thesis). Universidad del País VascoGoogle Scholar
- 29.Studies to Treat or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Prevention Study Group* (2008) Prevalence of the metabolic syndrome among a racially/ethnically diverse group of U.S. eighth-grade adolescents and associations with fasting insulin and homeostasis model assessment of insulin resistance levels. Diabetes Care 31:2020–2025CrossRefGoogle Scholar
- 31.Chen SK, Luo JS, Qin YF, Fan X, Tang Q, Feng Y (2011) Epidemiological study on the association between obesity with metabolic syndrome in obese children and adolescents of Nanning city, Guangxi. Zhonghua Liu Xing Bing Xue Za Zhi 32:969–972Google Scholar
- 32.Wang SQ, Liu YJ, Zhan J, Liu XL, Feng Q, Gong J, Talbott EO, He QQ (2013) Determinants of metabolic syndrome in Chinese schoolchildren. Asia Pac J Public Health 4. doi: 10.1177/1010539513496137
- 34.Khuc K, Blanco E, Burrows R, Reyes M, Castillo M, Lozoff B, Gahagan S (2012) Adolescent metabolic syndrome risk is increased with higher infancy weight gain and decreased with longer breastfeeding. Int J Pediatr 5:478610Google Scholar
- 39.Merritt TA, Mazela J, Adamczak A, Merritt T (2012) The impact of second-hand tobacco smoke exposure on pregnancy outcomes, infant health, and the threat of third-hand smoke exposure to our environment and to our children. Prz Lek 69:717–720Google Scholar
- 40.Noda T (2013) Effects of tobacco smoke on fetus and children. Nihon Rinsho 71:454–458Google Scholar