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European Journal of Nutrition

, Volume 54, Issue 2, pp 205–214 | Cite as

Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study

  • Ngoc Minh Pham
  • Akiko Nanri
  • Kazuki Yasuda
  • Kayo Kurotani
  • Keisuke Kuwahara
  • Shamima Akter
  • Masao Sato
  • Hitomi Hayabuchi
  • Tetsuya Mizoue
Original Contribution

Abstract

Purpose

Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.

Methods

The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20–68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.

Results

Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.

Conclusions

Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.

Keywords

Coffee Green tea Adipokines Japanese 

Notes

Acknowledgments

We are grateful to the study participants for their cooperation and participation. We also thank Seiko Miyazaki and Yasutaka Horiuchi (Kyushu University); Emi Tanaka, Youko Tsuruda, Misaki Hirose, Meishu Sai, Miho Isayama, Midori Sasaki, Mie Shimomura and Azumi Uehara (Fukuoka Women’s University); Yaeko Nagano (retired nurse); and Akiko Hayashi, Yu Teruyama, Kae Saito, Kayoko Washizuka and Yuho Mizoue (National Center for Global Health and Medicine) for their help in data collection. We extend our thanks to Kazuko Nagase and Dai Suzuki (Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine) for their contributions to measurements of serum adipokines. This study was supported by a Grant-in-Aid for Scientific Research (B) (21390213) from the Japan Society for the Promotion of Science (To Dr Mizoue), a Grant-in-Aid for Young Scientists (B) (21790598) from the Ministry of Education, Culture, Sports, Science and Technology and a Grant of National Center for Global Health and Medicine (To Dr Nanri).

Conflict of interest

None.

Supplementary material

394_2014_701_MOESM1_ESM.docx (29 kb)
Supplementary material 1 (DOCX 28 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ngoc Minh Pham
    • 1
  • Akiko Nanri
    • 1
  • Kazuki Yasuda
    • 2
  • Kayo Kurotani
    • 1
  • Keisuke Kuwahara
    • 1
  • Shamima Akter
    • 1
  • Masao Sato
    • 3
  • Hitomi Hayabuchi
    • 4
  • Tetsuya Mizoue
    • 1
  1. 1.Department of Epidemiology and Prevention, Center for Clinical SciencesNational Center for Global Health and MedicineTokyoJapan
  2. 2.Department of Metabolic Disorder, Diabetes Research CenterNational Center for Global Health and MedicineTokyoJapan
  3. 3.Department of Applied Biological Chemistry, Graduate School of Bioresource and Bioenvironmental SciencesKyushu UniversityFukuokaJapan
  4. 4.Graduate School of Nutrition and Health ScienceFukuoka Women’s UniversityFukuokaJapan

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