Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study
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Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.
The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20–68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.
Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.
Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.
KeywordsCoffee Green tea Adipokines Japanese
We are grateful to the study participants for their cooperation and participation. We also thank Seiko Miyazaki and Yasutaka Horiuchi (Kyushu University); Emi Tanaka, Youko Tsuruda, Misaki Hirose, Meishu Sai, Miho Isayama, Midori Sasaki, Mie Shimomura and Azumi Uehara (Fukuoka Women’s University); Yaeko Nagano (retired nurse); and Akiko Hayashi, Yu Teruyama, Kae Saito, Kayoko Washizuka and Yuho Mizoue (National Center for Global Health and Medicine) for their help in data collection. We extend our thanks to Kazuko Nagase and Dai Suzuki (Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine) for their contributions to measurements of serum adipokines. This study was supported by a Grant-in-Aid for Scientific Research (B) (21390213) from the Japan Society for the Promotion of Science (To Dr Mizoue), a Grant-in-Aid for Young Scientists (B) (21790598) from the Ministry of Education, Culture, Sports, Science and Technology and a Grant of National Center for Global Health and Medicine (To Dr Nanri).
Conflict of interest
- 27.Tsioufis C, Dimitriadis K, Vasiliadou C, Taxiarchou E, Vezali E, Tsiamis E, Stefanadis C, Kallikazaros I (2006) Heavy coffee consumption in conjunction with smoking is accompanied by increased inflammatory processes and impaired thrombosis/fibrinolysis system in essential hypertensive subjects. J Hum Hypertens 20:470–472CrossRefGoogle Scholar
- 33.Kobayashi S, Murakami K, Sasaki S, Okubo H, Hirota N, Notsu A, Fukui M, Date C (2011) Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutr 14:1200–1211CrossRefGoogle Scholar
- 34.Science and Technology Agency (2005) Standard tables of food composition in japan, 5th revised. Printing Bureau of the Ministry of Finance, TokyoGoogle Scholar
- 36.National Cholesterol Education Program (NCEP) Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 106:3143–3421Google Scholar
- 40.D’Avanzo B, La Vecchia C, Tognoni G, Franceschi S, Franzosi MG, Nobili A, Santoro L, Scarsi G (1993) Coffee consumption and risk of acute myocardial infarction in Italian males. GISSI-EFRIM. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto, Epidemiologia dei Fattori di Rischio del’Infarto Miocardico. Ann Epidemiol 3:595–604CrossRefGoogle Scholar
- 42.Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, Kim JA, Quon MJ, Montagnani M (2007) EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 292:E1378–E1387CrossRefGoogle Scholar
- 49.Greenberg JA, Boozer CN, Geliebter A (2006) Coffee, diabetes, and weight control. Am J Clin Nutr 84:682–693Google Scholar
- 51.Lopez-Garcia E, van Dam RM, Qi L, Hu FB (2006) Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am J Clin Nutr 84:888–893Google Scholar
- 53.Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91:3527–3561Google Scholar
- 56.Rosner B (2010) Multisample inference. Fundamentals of biostatistics, 7th edn. Cengage Learning, Boston, pp 516–587Google Scholar