European Journal of Nutrition

, Volume 53, Issue 7, pp 1573–1579 | Cite as

Coffee and caffeine intake and risk of endometriosis: a meta-analysis

  • Francesca Chiaffarino
  • Francesca Bravi
  • Sonia Cipriani
  • Fabio Parazzini
  • Elena Ricci
  • Paola Viganò
  • Carlo La Vecchia
Original Contribution



The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue.


We performed a meta-analysis of epidemiological studies published up to January 2013. We computed summary relative risks (RR) of endometriosis for any, high and low versus no coffee/caffeine consumption.


We identified a total eight studies, six case–control and two cohort studies, including a total of 1,407 women with endometriosis. The summary RR for any versus non-consumption were 1.26 [95 % confidence interval (CI) 0.95–1.66] for caffeine and 1.13 (95 % CI 0.46–2.76) for coffee consumption; the overall estimate was 1.18 (95 % CI 0.92–1.49). The summary RR were 1.09 (95 % CI 0.84–1.42) and 1.09 (95 % CI 0.89–1.33) for high and low caffeine consumption as compared to no consumption, respectively.


The present meta-analysis provided no evidence for an association between coffee/caffeine consumption and the risk of endometriosis. Coffee/caffeine consumption, as currently used in diet, does not carry a health risk.


Epidemiology Coffee/caffeine intake Meta-analysis Clinical epidemiology Gender medicine Women’s health 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Francesca Chiaffarino
    • 1
  • Francesca Bravi
    • 2
    • 3
  • Sonia Cipriani
    • 1
    • 2
  • Fabio Parazzini
    • 1
    • 2
  • Elena Ricci
    • 1
  • Paola Viganò
    • 4
  • Carlo La Vecchia
    • 2
    • 3
  1. 1.Department of Obstetrics, Gynecology and NeonatologyIRCSS Fondazione Ca’ Granda, Ospedale Maggiore PoliclinicoMilanItaly
  2. 2.IRCCS “Mario Negri” Institute for Pharmacological ResearchMilanItaly
  3. 3.Department of Clinical Medicine and Community HealthUniversity of MilanMilanItaly
  4. 4.Obstetrics and Gynecology UnitSan Raffaele Scientific InstituteMilanItaly

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