European Journal of Nutrition

, Volume 53, Issue 7, pp 1503–1510 | Cite as

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

  • João Marcus Oliveira Andrade
  • Alessandra Caroline Montes Frade
  • Juliana Bohnen Guimarães
  • Kátia Michelle Freitas
  • Miriam Teresa Paz Lopes
  • André Luiz Sena Guimarães
  • Alfredo Maurício Batista de Paula
  • Cândido Celso Coimbra
  • Sérgio Henrique Sousa SantosEmail author
Original Contribution



Adipose tissue is central to the regulation of energy balance. Two functionally different fat pads are present in mammals: white adipose tissue, the primary site of triglyceride storage, and brown adipose tissue (BAT), which is specialized in heat production. In this context, new strategies capable of modulating the development and function of white and BAT become relevant. In the present study, we analyzed the influence of resveratrol (sirtuin activator) on energy balance and the expression of thermogenesis markers.


Mice were divided into two groups: standard diet (ST) and standard diet plus resveratrol (ST + RSV).


After 2 months of treatment, ST + RSV mice presented significantly decreased fat accumulation in adipose tissue, with diminished total cholesterol and glucose plasma levels. Additionally, increased oxygen consumption was observed in ST + RSV group. Analyses of mRNA of thermogenesis-related genes showed significant increase in UCP1, SIRT1, PTEN and BMP-7 expression in BAT.


Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1 and SIRT1, which can mediate higher energy expenditure and decreased fat accumulation in adipose tissue.


Thermogenesis PTEN Adipose tissue SIRT1 UCP1 



This work was partially supported by the Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq) and Minas Gerais State Foundation for Research Development (FAPEMIG).

Conflict of interest

There is no conflict of interest to disclose for any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • João Marcus Oliveira Andrade
    • 3
  • Alessandra Caroline Montes Frade
    • 1
  • Juliana Bohnen Guimarães
    • 2
  • Kátia Michelle Freitas
    • 1
  • Miriam Teresa Paz Lopes
    • 1
  • André Luiz Sena Guimarães
    • 3
  • Alfredo Maurício Batista de Paula
    • 3
  • Cândido Celso Coimbra
    • 2
  • Sérgio Henrique Sousa Santos
    • 1
    • 3
    • 4
    Email author
  1. 1.Pharmacology Department, Biological Sciences InstituteFederal University of Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Physiology and Biophysics Department, Biological Sciences InstituteFederal University of Minas Gerais (UFMG)Belo HorizonteBrazil
  3. 3.Laboratory of Health Science, Postgraduate Program in Health SciencesUniversidade Estadual de Montes Claros (UNIMONTES)Montes ClarosBrazil
  4. 4.Departamento de FarmacologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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