European Journal of Nutrition

, Volume 53, Issue 5, pp 1255–1262

The effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial

  • A. M. Alavi Naeini
  • I. Elmadfa
  • A. Djazayery
  • M. Barekatain
  • M. R. Aghaye Ghazvini
  • M. Djalali
  • A. Feizi
Original Contribution

DOI: 10.1007/s00394-013-0628-1

Cite this article as:
Alavi Naeini, A.M., Elmadfa, I., Djazayery, A. et al. Eur J Nutr (2014) 53: 1255. doi:10.1007/s00394-013-0628-1

Abstract

Purpose

This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran.

Methods

About 256 elderly with mild cognitive impairment, aged 60–75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year.

Background

Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined.

Results

Antioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively).

Conclusion

Despite significant improvement in most of the oxidative stress biomarkers, antioxidants’ supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected.

Keywords

Supplementation The elderly Mild cognitive impairment Vitamin E Vitamin C 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • A. M. Alavi Naeini
    • 1
  • I. Elmadfa
    • 2
    • 6
  • A. Djazayery
    • 1
  • M. Barekatain
    • 3
  • M. R. Aghaye Ghazvini
    • 4
  • M. Djalali
    • 1
  • A. Feizi
    • 5
  1. 1.School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran
  2. 2.Institute of Nutritional SciencesUniversity of ViennaViennaAustria
  3. 3.Department of Psychiatry and Behavioral SciencesIsfahan University of Medical SciencesIsfahanIran
  4. 4.Isfahan Center of Health Research, Nationally Institute of Health ResearchTehran University of Medical ScienceTehranIran
  5. 5.Department of Biostatistics and EpidemiologyIsfahan University of Medical SciencesIsfahanIran
  6. 6.International Union of Nutritional Sciences (IUNS)ViennaAustria

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