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European Journal of Nutrition

, Volume 52, Issue 8, pp 1901–1911 | Cite as

Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations

  • Meng Yang
  • Sang-Jin Chung
  • Anna Floegel
  • Won O. Song
  • Sung I. Koo
  • Ock K. ChunEmail author
Original Contribution

Abstract

Purpose

To investigate the associations of dietary TAC from diet and supplements with serum antioxidant concentrations and serum C-reactive protein (CRP) and plasma total homocysteine (tHcy) in US adults.

Methods

This was a cross-sectional study. Food consumption data, serum antioxidant levels, and serum CRP and Plasma tHcy concentrations of 4,391 US adults aged ≥19 years in the National Health and Nutrition Examination Survey 2001–2002 were analyzed. The USDA flavonoid and proanthocyanidin databases and dietary supplement data as well as antioxidant capacities of 43 antioxidants were also utilized.

Result

Serum CRP and plasma tHcy concentrations were higher in older adults, smokers, and those with lower non-leisure time physical activity levels (P < 0.05). Energy-adjusted daily total antioxidant capacity (TAC) from diet and supplements was positively associated with serum vitamin E and carotenoid concentrations (P < 0.05). Adjusted odds ratio (OR) for plasma tHcy >13 μmol/L significantly decreased across quartiles of TAC from diet and supplements (Q1 = 2.18 (1.56–2.77); Q2 = 1.30 (1.00–2.07); Q3 = 1.34 (0.84–2.28); Q4 = 1.00; P for linear trend <0.001). A negative trend across quartiles of TAC from diet and supplements was also observed in OR for serum CRP ≥3 mg/L (Q1 = 1.26 (0.97–1.70); Q2 = 1.21 (0.91–1.66); Q3 = 0.97 (0.80–1.24); Q4 = 1.00; P for linear trend <0.05).

Conclusions

These findings indicated that dietary TAC provided an integrated conceptual tool in assessing serum antioxidants and investigating the associations between antioxidant intake and CVD risk. The implicated applicability of dietary TAC needs further validation in prospective cohort studies.

Keywords

Dietary total antioxidant capacity Cardiovascular disease C-reactive protein Total homocysteine Diet Supplements 

Notes

Acknowledgments

This research was fully funded by the Beginning Grant in Aid No. 0865092E from the American Heart Association. This article was partially presented at the 2010 Experimental Biology Meeting, Anaheim, CA, in April 2010.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Meng Yang
    • 1
  • Sang-Jin Chung
    • 2
  • Anna Floegel
    • 3
  • Won O. Song
    • 4
  • Sung I. Koo
    • 1
  • Ock K. Chun
    • 1
    Email author
  1. 1.Department of Nutritional SciencesUniversity of ConnecticutStorrsUSA
  2. 2.Department of Foods and NutritionKookmin UniversitySeoulKorea
  3. 3.Department of EpidemiologyGerman Institute of Human Nutrition, Potsdam-RehbrueckeNuthetalGermany
  4. 4.Department of Food Science and Human NutritionMichigan State UniversityEast LansingUSA

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