European Journal of Nutrition

, Volume 52, Issue 6, pp 1641–1648 | Cite as

Serum leptin and total dietary energy intake: the INTERLIPID Study

  • Yasuyuki NakamuraEmail author
  • Hirotsugu Ueshima
  • Nagako Okuda
  • Yoshitaka Murakami
  • Katsuyuki Miura
  • Yoshikuni Kita
  • Tomonori Okamura
  • Akira Okayama
  • Tanvir C. Turin
  • Sohel R. Choudhry
  • Beatriz Rodriguez
  • J. David Curb
  • Jeremiah Stamler
Original Contribution



It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese–Americans in Hawaii and Japanese in Japan.


Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40–59 years from two population samples, one Japanese–American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25–29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake.


In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m2 (P < 0.001).


Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.


Leptin Japanese in Japan and Hawaii Obesity Body mass Total energy intake Population study 



The INTERMAP/INTERLIPID Study has been accomplished through the fine work of staff at local, national, and international centers. A partial listing of colleagues is in the acknowledgement of reference 10. This study was supported in part by a grant-in-aid of the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research: (A) 090357003, (C) 17590563, and (C) 19590655 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP Study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490), as well as national and local agencies in the four countries.

Conflict of interest

All authors have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Yasuyuki Nakamura
    • 1
    • 2
    Email author
  • Hirotsugu Ueshima
    • 2
  • Nagako Okuda
    • 3
  • Yoshitaka Murakami
    • 4
  • Katsuyuki Miura
    • 2
  • Yoshikuni Kita
    • 2
  • Tomonori Okamura
    • 5
  • Akira Okayama
    • 3
  • Tanvir C. Turin
    • 2
  • Sohel R. Choudhry
    • 6
  • Beatriz Rodriguez
    • 7
  • J. David Curb
    • 7
  • Jeremiah Stamler
    • 8
  1. 1.Cardiovascular EpidemiologyKyoto Women’s UniversityKyotoJapan
  2. 2.Department of Health ScienceShiga University of Medical ScienceOtsuJapan
  3. 3.The First Institute of Health Service, Japan Anti-Tuberculosis AssociationTokyoJapan
  4. 4.Department of Medical StatisticsShiga University of Medical ScienceOtsuJapan
  5. 5.Department of Preventive CardiologyNational Cardiovascular CenterSuitaJapan
  6. 6.Department of Epidemiology and ResearchNational Heart Foundation Hospital and Research InstituteDhakaBangladesh
  7. 7.Department of Geriatric Medicine, John A Burns School of MedicineUniversity of HawaiiHonoluluUSA
  8. 8.Feinberg School of MedicineNorthwestern UniversityChicagoUSA

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