Serum leptin and total dietary energy intake: the INTERLIPID Study
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It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese–Americans in Hawaii and Japanese in Japan.
Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40–59 years from two population samples, one Japanese–American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25–29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake.
In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m2 (P < 0.001).
Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
KeywordsLeptin Japanese in Japan and Hawaii Obesity Body mass Total energy intake Population study
The INTERMAP/INTERLIPID Study has been accomplished through the fine work of staff at local, national, and international centers. A partial listing of colleagues is in the acknowledgement of reference 10. This study was supported in part by a grant-in-aid of the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research: (A) 090357003, (C) 17590563, and (C) 19590655 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP Study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490), as well as national and local agencies in the four countries.
Conflict of interest
All authors have no conflict of interest.
- 13.Nakamura Y, Ueshima H, Okuda N et al (2008) Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study. Am J Clin Nutr 88:424–430Google Scholar
- 17.Broeder CE, Burrhus KA, Svanevik LS, Wilmore JH (1992) The effects of aerobic fitness on resting metabolic rate. Am J Clin Nutr 55:795–801Google Scholar
- 25.Westerterp-Plantenga MS, Saris WH, Hukshorn CJ, Campfield LA (2001) Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men. Am J Clin Nutr 74:426–434Google Scholar
- 33.Niskanen LK, Haffner S, Karhunen LJ, Turpeinen AK, Miettinen H, Uusitupa MI (1997) Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol 137(61–6):7Google Scholar