Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005
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Cord serum (CS) phospholipid fatty acid composition is associated with maternal diet during foetal life, and maternal intake of linoleic acid (LA, C18:2ω-6) and α-linolenic acid (LNA, C18:3 ω-3) has been shown to influence the LA and LNA levels in CS. A possible connection between the increased incidence of atopic diseases and increased intake of LA and decreased intake of LNA in the Western world has been proposed.
The aim of this study was to explore phospholipid fatty acid proportions and total IgE levels in CS from Swedish children, collected from 1985 to 2005, a period with increasing frequency of allergic diseases in Sweden, and reveal possible changes over time.
Phospholipid fatty acids and total IgE antibodies were analysed with gas chromatography and UniCAP® technology, respectively, in 300 CS samples.
The proportions of LA and LNA decreased significantly from 1985 to 2005 (p < 0.001 for both). However, the LA/LNA ratio did increase (p < 0.001), revealing a relatively larger decrease in LNA than in LA. No correlations were found between ω-6 and ω-3 fatty acids and total IgE antibodies in CS from newborn children.
The LA/LNA ratio increased (p < 0.001) in cord serum samples collected between 1985 and 2005, and no correlations between fatty acids and total IgE were found.
KeywordsCord blood Fatty acids Immunoglobulin E
The authors wish to thank the midwives at the maternity ward at the University Hospital in Linköping for endless patience with collecting the cord blood samples. Professor Birgitta Strandvik and Mrs. Berit Holmberg, Department of Pediatrics, Institute of the Health of Women and Children, Göteborg University, Göteborg, are acknowledged for kindly providing the PUFA phospholipids analysis technique. We also wish to thank Dr. Olle Eriksson and Dr. Anneli Sepa for statistical guidance and Dr. Jenny Walldén for laboratory support. The study was financially supported by the Swedish Nutrition Foundation (SNF).
Conflict of interest
The authors declare no conflict of interest.
- 2.Crawford MA (1993) The role of essential fatty acids in neural development: implications for perinatal nutrition. Am J Clin Nutr 57(5 Suppl):703S–9S. discussion 9S–10SGoogle Scholar
- 4.Bourre JM (2004) Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J Nutr Health Aging 8(3):163–174Google Scholar
- 6.Dutta-Roy AK (2000) Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 71(1 Suppl):315S–322SGoogle Scholar
- 8.Deckelbaum RJ, Worgall TS, Seo T (2006) n-3 fatty acids and gene expression. Am J Clin Nutr 83(6 Suppl):1520S–1525SGoogle Scholar
- 10.Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK et al (2006) Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet 368(9537):733–743CrossRefGoogle Scholar
- 17.von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH (1994) Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 149(2 Pt 1):358–364Google Scholar
- 20.Ronmark E, Bjerg A, Perzanowski M, Platts-Mills T, Lundback B (2009) Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J Allergy Clin Immunol 124(2):357–363, 63 e1-15Google Scholar
- 21.Folch J, Lees M (1957) Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226(1):497–509Google Scholar
- 22.Kaluzny MA, Duncan LA, Merritt MV, Epps DE (1985) Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 26(1):135–140Google Scholar
- 24.Furuhjelm C, Warstedt K, Fageras M, Falth-Magnusson K, Larsson J, Fredriksson M, et al. (2011) Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. [Research Support, Non-U.S. Gov’t] 22(5):505–514Google Scholar
- 27.Bolte G, Frye C, Hoelscher B, Meyer I, Wjst M, Heinrich J (2001) Margarine consumption and allergy in children. Am J Respir Crit Care Med 163(1):277–279Google Scholar
- 30.Pesonen M, Kallio MJ, Siimes MA, Elg P, Bjorksten F, Ranki A (2008) Cord serum immunoglobulin E as a risk factor for allergic symptoms and sensitization in children and young adults. Pediatr Allergy ImmunolGoogle Scholar
- 31.Kjellman NI, Croner S (1984) Cord blood IgE determination for allergy prediction—a follow-up to seven years of age in 1,651 children. Ann Allergy 53(2):167–171Google Scholar