Treatment for vitamin D deficiency: here and there do not mean everywhere
- 140 Downloads
The optimal levels of vitamin D and the best treatment for vitamin D deficiency are the object of intense discussion. As for the threshold value of 25-hydroxyvitamin D (25(OH)D) defining a sufficient vitamin D status, a dedicated Committee of the Institute of Medicine recently stated that a serum concentration of at least 50 nmol/L meets the needs of at least 97.5% of the population [1, 2]. The corresponding recommended dietary allowance (RDA) in adults is 600 IU per day up to 70 years of age and 800 IU daily thereafter. Notably, these intakes are based on an assumption of minimal or no sun exposure. The IOM Committee’s members considered bone health as the only outcome consistently and causally linked to vitamin D and concluded that studies about the potential positive effects of vitamin D on calcium absorption and balance, physical performance, and risk of falls are still inconclusive as to causality. However, many experts deem the evidence that vitamin D supplementation improves...
KeywordsRickets Osteomalacia North Latitude Recommended Dietary Allowance Serum Parathyroid Hormone
- 1.Institute of Medicine (2011) Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington, DCGoogle Scholar
- 2.Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58CrossRefGoogle Scholar
- 6.Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, Püschel K, Amling M (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25:305–312CrossRefGoogle Scholar
- 7.Toss G, Magnusson P (2011) Is a daily supplementation with 40 microgram vitamin D(3) sufficient? A randomised controlled trial. Eur J Nutr. doi: 10.1007/s00394-011-0271-7