Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality
Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans.
The aim of our investigation was to ascertain whether ingestion of a tart cherry juice concentrate would increase the urinary melatonin levels in healthy adults and improve sleep quality.
In a randomised, double-blind, placebo-controlled, crossover design, 20 volunteers consumed either a placebo or tart cherry juice concentrate for 7 days. Measures of sleep quality recorded by actigraphy and subjective sleep questionnaires were completed. Sequential urine samples over 48 h were collected and urinary 6-sulfatoxymelatonin (major metabolite of melatonin) determined; cosinor analysis was used to determine melatonin circadian rhythm (mesor, acrophase and amplitude). In addition, total urinary melatonin content was determined over the sampled period. Trial differences were determined using a repeated measures ANOVA.
Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude.
These data suggest that consumption of a tart cherry juice concentrate provides an increase in exogenous melatonin that is beneficial in improving sleep duration and quality in healthy men and women and might be of benefit in managing disturbed sleep.
KeywordsTart cherries Melatonin Sleep Recovery
Gratitude is extended to Kelly Mitcheson for her help in data collection and to CherryActive (Sunbury, UK) for donating the cherry juice concentrate.
- 1.Jacob RA, Spinozzi GM, Simon VA, Kelley DS, Prior RL, Hess-Pierce B, Kader AA (2003) Consumption of cherries lowers plasma urate in healthy women. J Nutr 133(6):1826–1829Google Scholar
- 2.Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE (2006) Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr 136(4):981–986Google Scholar
- 13.Hughes RJ, Sack RL, Lewy AJ (1998) The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement. Sleep 21(1):52–66Google Scholar
- 18.Iinuma F, Hamase K, Matsubayashi S, Takahashi M, Watanabe M, Zaitsu K (1999) Sensitive determination of melatonin by precolumn derivatization and reversed-phase high-performance liquid chromatography. J Chromatogr A 835(1–2):67–72Google Scholar
- 19.Herxheimer A, Pertrie KJ (2002) Melatonin for the prevention of jet lag. Cochrane Database Syst Rev 9:11–24Google Scholar
- 20.Aldhous ME, Arendt J (1988) Radioimmunoassay for 6-sulphatoxymelatonin in urine using an iodinated tracer. Ann Clin Biochem 25(3):298–303Google Scholar
- 23.Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP (2003) The role of actigraphy in the study of sleep and circadian rythyms. Sleep 26(3):342–392Google Scholar
- 26.Garrido M, Paredes SD, Cubero J, Lozano M, Toribio-Delgado AF, Muñoz JL, Reiter RJ, Barriga C, Rodríguez AB (2010) Jerte valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J Gerontol Ser A Biol Sci Med Sci. doi: 10.1093/gerona/glq099
- 27.Coyne MD, Kesick CM, Doherty TJ, Kolka MA, Stephenson LA (2000) Circadian rhythm changes in core temperature over the menstrual cycle: method for noninvasive monitoring. Am J Physiol Regul Integr Comp Physiol 279:R1316–R1320Google Scholar