Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise
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Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.
The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q10 (CoQ10) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.
The participants were classified in two groups: CoQ10 group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.
Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ10 during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ10 prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ10 supplementation reduced creatinine production.
CoQ10 supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.
KeywordsHigh-intensity (strenuous) exercise Coenzyme Q10 Oxidative damage Inflammation
The authors are grateful to the University of Granada for the personal support of J. Díaz-Castro.
Conflict of interest
The authors have declared that no conflict of interest exists.
- 1.Siddiqui NI, Nessa A, Hossain MA (2010) Regular physical exercise: way to healthy life. Mymensingh Med J 19:154–158Google Scholar
- 8.Sen CK (1995) Oxidants and antioxidants in exercise. J Appl Physiol 79:675–686Google Scholar
- 12.Koren A, Sauber C, Sentjurc M, Schara M (1983) Free radicals in tetanic activity of isolated skeletal muscle. Comp Biochem Physiol 74:633–635Google Scholar
- 15.Zhou S, Zhang Y, Davie A, Marshall-Gradisnik S, Hu H, Wang J, Brushett D (2005) Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. J Sports Med Phys Fitness 45:337–346Google Scholar
- 17.Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R (2008) Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr 5:8CrossRefGoogle Scholar
- 25.Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78:547–581Google Scholar
- 26.Ochoa JJ, Quiles JL, López-Frías M, Huertas FJ, Mataix J (2007) Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet. J Gerontol 62:1211–1218CrossRefGoogle Scholar
- 31.Jones K, Hughes K, Mischley L, McKenna DJ (2002) Coenzyme Q-10: efficacy, safety, and use. Altern Ther Health Med 8:42–55Google Scholar
- 33.Jung HJ, Park EH, Lim CJ (2009) Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals. J Pharm Pharmacol 61:1391–1395Google Scholar
- 41.Kuru S, Inukai A, Kato T, Liang Y, Kimura S, Sobue G (2003) Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and noninflammatory myopathies. Acta Neuropathol 105:217–224Google Scholar
- 43.Starace D, Riccioli A, D’Alessio A, Giampietri C, Petrungaro S, Galli R, Filippini A, Ziparo E, De Cesaris P (2005) Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB. FASEB J 19:473–475Google Scholar
- 44.Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF (1992) Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci USA 89:4845–4849CrossRefGoogle Scholar
- 45.Van Mierlo GJ, Scherer HU, Hameetman M, Morgan ME, Flierman R, Huizinga TW, Toes RE (2008) Cutting edge: TNFR-shedding by CD4 + CD25 + regulatory T cells inhibits the induction of inflammatory mediators. J Immunol 180:2747–2751Google Scholar
- 46.Serrano J, Alonso D, Encinas JM, Lopez JC, Fernandez AP, Castro-Blanco S, Fernández-Vizarra P, Richart A, Bentura ML, Santacana M, Uttenthal LO, Cuttitta F, Rodrigo J, Martinez A (2002) Adrenomedullin expression is upregulated by ischemia-reperfusion in the cerebral cortex of the adult rat. Neuroscience 109:717–731CrossRefGoogle Scholar