A sodium-bicarbonated mineral water reduces gallbladder emptying and postprandial lipaemia: A randomised four-way crossover study
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Sodium-bicarbonated mineral waters are reported to have beneficial digestive and hypocholesterolaemic properties. The aim of the study was to investigate the effects of consumption of a sodium-bicarbonated mineral water (BW) with or without a meal, compared to a low mineral content water as the control water (CW), on postprandial serum triacylglycerols (TAG), cholecystokinin (CCK) and gallbladder volume.
The study design was a four-way randomised controlled crossover trial. Healthy adult men and women (>18 and <40 years, TAG <2.82 mmol/L) consumed 0.5 L of CW + standard meal; 0.5 L of BW + standard meal; and 0.5 L of CW without meal or 0.5 L of BW without meal.
BW consumed without meal had no significant effect on the study parameters compared to CW. However, BW with meal induced a lower concentration of serum TAG at 30 min (p = 0.01) and 60 min (p = 0.03) postprandial times, lower CCK concentrations at 30 min (p = 0.002), and higher gallbladder volume at 30 min (p = 0.03), 60 min (p = 0.01) and 120 min (p = 0.04). Gallbladder ejection fraction was lower with the BW (p = 0.03), whilst area under the curve and peak contraction amplitude (lowest gallbladder volume) were higher (p = 0.01, p = 0.02, respectively) compared to the CW.
Consumption of BW with a meal induces lower levels of CCK and reduces gallbladder emptying and postprandial TAG levels. It is proposed that this sodium-bicarbonated mineral water could be used as part of the habitual diet by the general population in order to reduce cardiovascular risk.
KeywordsCardiovascular risk Cholecystokinin Gallbladder emptying Humans Postprandial triacylglycerols Sodium-bicarbonated mineral water
The authors are grateful to I. Wright and A. Díaz-Alvarez for technical support, and to the volunteers of this study. This study was supported by Vichy Catalán SL (Barcelona, Spain) and a JAE-predoc grant from European Social Fund and CSIC, Spain.
Conflict of interest
The authors have declared no conflict of interest.
- 2.Capurso A, Solfrizzi V, Panza F, Mastroianni F, Torres F, Del Parigi A, Colacicco AM, Capurso C, Nicoletti G, Veneziani B, Cellamare S, Scalabrino A (1999) Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water. Aging (Milano) 11(4):273–276Google Scholar
- 5.Schoppen S, Perez-Granados AM, Carbajal A, Oubina P, Sanchez-Muniz FJ, Gomez-Gerique JA, Vaquero MP (2004) A sodium-rich carbonated mineral water reduces cardiovascular risk in postmenopausal women. J Nutr 134(5):1058–1063Google Scholar
- 8.Kunes J, Zicha J, Jelinek J (2004) The role of chloride in deoxycorticosterone hypertension: selective sodium loading by diet or drinking fluid. Physiol Res 53(2):149–154Google Scholar
- 9.Ziomber A, Machnik A, Dahlmann A, Dietsch P, Beck FX, Wagner H, Hilgers KF, Luft FC, Eckardt KU, Titze J (2008) Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Am J Physiol Renal Physiol 295(6):F1752–F1763. doi: 10.1152/ajprenal.00531.2007 CrossRefGoogle Scholar
- 12.Schoppen S, Perez-Granados AM, Carbajal A, Sarria B, Navas-Carretero S, Pilar Vaquero M (2008) Sodium-bicarbonated mineral water decreases aldosterone levels without affecting urinary excretion of bone minerals. Int J Food Sci Nutr 59(4):347–355. doi: 10.1080/09637480701560308 CrossRefGoogle Scholar
- 13.Schoppen S, Sanchez-Muniz FJ, Perez-Granados M, Gomez-Gerique JA, Sarria B, Navas-Carretero S, Pilar Vaquero M (2007) Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women? Nutr Hosp 22(5):538–544Google Scholar
- 18.Schoppen S, Perez-Granados AM, Navas-Carretero S, Vaquero MP (2010) Postprandial lipaemia and endothelial adhesion molecules in pre- and postmenopausal Spanish women. Nutr Hosp 25(2):256–261Google Scholar
- 21.Schoppen S, Pérez-Granados AM, Sarriá B, Navas S, Carvajal A, Sánchez-Muñiz F, Vaquero MP (2003) Influence of an alkaline mineral water on postprandial lipaemia in postmenopausal women. P Nutr Soc 62:43Google Scholar
- 22.Toxqui L, Pérez-Granados AM, Blanco-Rojo R, Vaquero MP (2011) Sodium-bicarbonated mineral water reduces postprandial lipaemia in moderately hypercholesterolaemic young adults. http://www.nutritionsociety.org/files/uploads/24__OCS_Wednesday_6_July.pdf. Accessed 7 Sept 2011
- 24.Gasbarrini G, Arienti V, Magri F, Boriani L, Ugenti F, Belotti M (1991) Effects of bicarbonated-alkaline water (Uliveto) on gastric and gallbladder emptying in normal subjects. Ultrasonic evaluation. Minerva Med 82(1–2):59–62Google Scholar
- 25.Coiro V, Volpi R, Vescovi PP (1997) Choleretic and cholagogic effect of sulphuric sulfate water from the springs of Tobiano in cholestasis in alcohol related liver diseases. Clin Ter 148(1–2):15–22Google Scholar
- 26.Bellini M, Spataro M, Costa F, Tumino E, Ciapparrone G, Flandoli F, Rucco M, Maltinti G, Marchi S (1995) Gallbladder motility following intake of mineral bicarbonate-alkaline water. Ultrasonographic assessment. Minerva Med 86(3):75–80Google Scholar
- 30.Embleton JK, Pouton CW (1997) Structure and function of gastro-intestinal lipases. Adv Drug Deliv Rev 25(1):15–32. doi: 10.1016/S0169-409X(96)00488-7
- 31.Watanabe S, Lee KY, Chang TM, Berger-Ornstein L, Chey WY (1988) Role of pancreatic enzymes on release of cholecystokinin-pancreozymin in response to fat. Am J Physiol 254(6 Pt 1):G837–G842Google Scholar