Is vitamin D status known among children living in Northern Italy?
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To assess vitamin D status in children aged 2–220 months in northeastern Italy (latitude 46°). Serum 25-hydroxyvitamin D (25OHD) concentration was assessed in 93 children afferent to the Pediatric Department of the Hospital of Udine.
Vitamin D status was defined as follows: sufficient with serum 25OHD between 50 and 250 nmol/l (level 4); insufficient between 37.5 and 50 nmol/l (level 3); deficient less than 37.5 nmol/l (level 2); severely deficient if less than 12.5 nmol/l (level 1). We investigated the potential risk factors of vitamin D deficit.
We found that six children (6.4%) had level 1, 36 (38.7%) had level 2, 9 (9.7%) had level 3, and only 45.2% had sufficient level of 25OHD. Immigrate children had a higher risk for vitamin D deficiency if compared with Italians: 75% of non-Italian children had an insufficient 25OHD level compared with 47.0% of Italian children (p = 0.0036). There was a marked seasonal effect on 25OHD level: when plasma sample was withdrawn between November and May, only 29.4% of children showed sufficient vitamin D level, while 70.5% was insufficient (p < 0.0001). Among the obese children, 9.0% had sufficient level of 25OHD with 90% being deficient (p = 0.01). We did not find any significant difference in vitamin D status among children in different age groups.
Vitamin D deficiency is common in children living in northeastern Italy. The risk factors were winter season for blood withdrawal, non-Caucasian race, and obesity. These high-risk groups should be targeted for screening and educated about the need of sunlight exposure.
KeywordsNutrition Vitamin D Season Race
- 4.Canadian Paediatric Society Position Statement (2002) Vitamin D supplementation in northern native communities. Paediatr Child Health 7(7):459–472 (English, French)Google Scholar
- 6.Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C (2003) Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. Am J Clin Nutr 78(3):485–492Google Scholar
- 8.Heaney RP (1999) Lessons for nutritional science from vitamin D. Am J Clin Nutr 69(5):825–826Google Scholar
- 9.Lippi G, Montagnana M, Targher G (2007) Vitamin D deficiency among Italian children. CMAJ 177(12):1529–1530 author reply 1530Google Scholar
- 18.Huotari A, Herzig KH (2008) Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency. Int J Circumpolar Health 67(2–3):164–178Google Scholar
- 19.Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80(6 Suppl):1678S–1688SGoogle Scholar
- 22.Edidin DV, Levitsky LL, Schey W, Dumbovic N, Campos A (1980) Resurgence of nutritional rickets associated with breast-feeding and special dietary practices. Pediatrics 65(2):232–235Google Scholar
- 23.Kalkwarf HJ, Khoury JC, Lanphear BP (2003) Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin Nutr 77(1):257–265Google Scholar
- 24.Banca Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia a cura di Gnagnarella P, Salvini S, Parpinel M. Versione 1.2008. http://www.ieo.it/bda
- 26.Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72(3):690–693Google Scholar
- 27.Harkness L, Cromer B (2005) Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females. Osteoporos Int 16(1):109–113 [Epub 2004 Jun 2]Google Scholar