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European Journal of Nutrition

, Volume 50, Issue 4, pp 271–277 | Cite as

Effects of a diet with inulin-enriched pasta on gut peptides and gastric emptying rates in healthy young volunteers

  • Francesco Russo
  • Caterina Clemente
  • Michele Linsalata
  • Marisa Chiloiro
  • Antonella Orlando
  • Emanuele Marconi
  • Guglielmina Chimienti
  • Giuseppe Riezzo
Original Contribution

Abstract

Aim

Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects.

Methods

Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography.

Results

The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p < 0.05 Dunn’s post-test). With regard to gastric motility, along with a significant delay in both the final time and T 1/2 gastric emptying time, a positive correlation was found between T 1/2 and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group.

Conclusion

These results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.

Keywords

Corticotropin-releasing factor Diet Fibre Gastric emptying Gut peptides Inulin Metabolic syndrome Neurotensin Somatostatin 

Notes

Acknowledgment

This work was supported by a grant from the Italian Ministry of Health (#132).

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Francesco Russo
    • 1
  • Caterina Clemente
    • 1
  • Michele Linsalata
    • 1
  • Marisa Chiloiro
    • 2
  • Antonella Orlando
    • 1
  • Emanuele Marconi
    • 3
  • Guglielmina Chimienti
    • 4
  • Giuseppe Riezzo
    • 2
  1. 1.Laboratory of Experimental BiochemistryI.R.C.C.S. “Saverio de Bellis”Castellana Grotte (Bari)Italy
  2. 2.Laboratory of Experimental PathophysiologyI.R.C.C.S. “Saverio de Bellis”Castellana Grotte (Bari)Italy
  3. 3.DiSTAAMUniversity of MoliseCampobassoItaly
  4. 4.Department of Biochemistry and Molecular BiologyUniversity of BariBariItaly

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