Effects of a diet with inulin-enriched pasta on gut peptides and gastric emptying rates in healthy young volunteers
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Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects.
Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography.
The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p < 0.05 Dunn’s post-test). With regard to gastric motility, along with a significant delay in both the final time and T 1/2 gastric emptying time, a positive correlation was found between T 1/2 and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group.
These results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.
KeywordsCorticotropin-releasing factor Diet Fibre Gastric emptying Gut peptides Inulin Metabolic syndrome Neurotensin Somatostatin
This work was supported by a grant from the Italian Ministry of Health (#132).
- 4.Schulze MB, Liu S, Rimm EB, Manson JE, Willett WC, Hu FB (2004) Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr 80:348–356Google Scholar
- 5.Cuche G, Cuber JC, Malbert CH (2000) Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. Am J Physiol (Gastrointest Liver Physiol) 279:G925–G930Google Scholar
- 8.Brighenti F (2007) Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr 137(Suppl 11):S2552–S2556Google Scholar
- 16.Martínez V, Wang L, Rivier JE, Vale W, Taché Y (2002) Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J Pharmacol Exp Ther 301:611–617CrossRefGoogle Scholar
- 20.Marconi E, Carcea M (2001) Pasta from non-nutritional raw materials. Cereal Foods Word 46:522–530Google Scholar
- 23.American Association of Cereal Chemists Approved methods of the AACC, 11th edn. AACC, St Paul 2001Google Scholar
- 24.Roberfroid MB (1999) Caloric value of inulin and oligo-fructose. J Nutr 129:1436S–1437SGoogle Scholar
- 25.Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labò G (1985) Measurement of gastric emptying time by real time ultrasonography. Gastroenterology 89:752–759Google Scholar
- 27.Zorio E, Falco C, Arnau MA, España F, Osa A, Ramon LA et al (2006) Lipoprotein (a) in young individuals as a marker of the presence of ischemic heart disease and the severity of coronary lesions. Haematologica 91:562–566Google Scholar