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Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, β-glucan

A dose response study in obese women with increased risk for insulin resistance
  • Hyunsook Kim
  • Kim S. Stote
  • Kay M. Behall
  • Karen Spears
  • Bryan Vinyard
  • Joan M. Conway
ORIGINAL CONTRIBUTION

Abstract

Background

A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes.

Aim of the study

We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley to provide varying amounts of soluble fiber, β-glucan (0, 2.5, 5, 7.5 and 10 g).

Methods

Seventeen normoglycemic, obese women at increased risk for insulin resistance consumed 5 test meals within a randomized cross-over design after consuming controlled diets for 2 days. Blood samples for glucose and insulin response were obtained prior to and 30, 60, 120 and 180 min after consuming the test meals.

Results

Consumption of 10 g of β-glucan significantly reduced peak glucose response at 30 min and delayed the rate of glucose response. Area under the curve for 2 h-postprandial glycemic response was not affected by β-glucan content. However, peak and area under the curve of insulin responses were significantly affected by the β-glucan amount in an inverse linear relationship.

Conclusion

These data suggest that acute consumption of 10 g of β-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.

Keywords

soluble fiber obesity β-glucan insulin resistance glucose 

Notes

Acknowledgments

We express our gratitude to the staff of the Beltsville Human Study Facility, including the research kitchen staff: Evelyn Lashley, Sue Burns, Diane Shegogue, and Mattie Long and research assistants: Willa Mae Clark, Demetria Fletcher, and Razia Hussain We acknowledge ConAgra (Omaha, NE) for generously supplying the barley. And, especially we wish to thank each volunteer for their participation and commitment to making this study possible.

References

  1. 1.
    Behall KM, Scholfield DJ, Hallfrisch J (2005) Comparison of hormone and glucose responses of overweight women to barley and oats. J Am Coll Nutr 24:182–188Google Scholar
  2. 2.
    Behall KM, Scholfield DJ, Hallfrisch J (2004) Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am J Clin Nutr 80:1185–1193Google Scholar
  3. 3.
    Behall KM, Scholfield DJ, Hallfrisch J (2004) Lipids significantly reduced by diets containing barley in moderately hypercholesterolemic men. J Am Coll Nutr 23:55–62Google Scholar
  4. 4.
    Behall KM, Scholfield DJ, Hallfrisch J (2006) Whole-grain diets reduce blood pressure in mildly hypercholesterolemic men and women. J Am Diet Assoc 106:1445–1449CrossRefGoogle Scholar
  5. 5.
    Behall KM, Scholfield DJ, Hallfrisch JG, Liljeberg-Elmstahl HG (2006) Consumption of both resistant starch and beta-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care 29:976–981CrossRefGoogle Scholar
  6. 6.
    Braaten JT, Scott FW, Wood PJ, Riedel KD, Wolynetz MS, Brule D, Collins MW (1994) High beta-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes. Diabetes Med 11:312–318CrossRefGoogle Scholar
  7. 7.
    Dubois C, Armand M, Senft M, Portugal H, Pauli AM, Bernard PM, Lafont H, Lairon D (1995) Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults. Am J Clin Nutr 61:325–333Google Scholar
  8. 8.
    Gatenby SJ, Ellis PR, Morgan LM, Judd PA (1996) Effect of partially depolymerized guar gum on acute metabolic variables in patients with non-insulin-dependent diabetes. Diabet Med 13:358–364CrossRefGoogle Scholar
  9. 9.
    Hagander B, Schersten B, Asp NG, Sartor G, Agardh CD, Schrezenmeir J, Kasper H, Ahren B, Lundquist I (1984) Effect of dietary fibre on blood glucose, plasma immunoreactive insulin, C-peptide and GIP responses in non insulin dependent (type 2) diabetics and controls. Acta Med Scand 215:205–213Google Scholar
  10. 10.
    Hallfrisch J, Scholfield DJ, Behall KM (2003) Physiological responses of men and women to barley and oat extracts (Nu-trimX). II: comparison of glucose and insulin responses. Cereal Chem 80:80–83CrossRefGoogle Scholar
  11. 11.
    Hinata M, Ono M, Midorikawa S, Nakanishi K (2007) Metabolic improvement of male prisoners with type 2 diabetes in Fukushima Prison, Japan. Diabetes Res Clin Pract 77:327–332CrossRefGoogle Scholar
  12. 12.
    Jenkins DJ, Kendall CW, Vuksan V, Vidgen E, Parker T, Faulkner D, Mehling CC, Garsetti M, Testolin G, Cunnane SC, Ryan MA, Corey PN (2002) Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr 75:834–839Google Scholar
  13. 13.
    Kabir M, Oppert JM, Vidal H, Bruzzo F, Fiquet C, Wursch P, Slama G, Rizkalla SW (2002) Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metabolism 51:819–826CrossRefGoogle Scholar
  14. 14.
    Kim H, Behall KM, Vinyard B, Conway J (2006) Short-term satiety and glycemic response after consumption of whole grains with various amounts of β-glucan. Cereal Foods World 51:29–33Google Scholar
  15. 15.
    Liese AD, Roach AK, Sparks KC, Marquart L, D’Agostino RB Jr, Mayer-Davis EJ (2003) Whole-grain intake and insulin sensitivity: the insulin resistance atherosclerosis study. Am J Clin Nutr 78:965–971Google Scholar
  16. 16.
    Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419CrossRefGoogle Scholar
  17. 17.
    McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, Temple LA, Duncan AW (2001) Diagnosing insulin resistance in the general population. Diabetes Care 24:460–464CrossRefGoogle Scholar
  18. 18.
    McCleary B, Glennie-Holmes M (1985) Enzymatic quantification of (1–3), (1–4)-β-d-glucan in barley and malt. J Inst Brew 95:285–295Google Scholar
  19. 19.
    Meigs JB, Rutter MK, Sullivan LM, Fox CS, D’Agostino RB Sr, Wilson PW (2007) Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome. Diabetes Care 30:1219–1225CrossRefGoogle Scholar
  20. 20.
    Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM (2007) Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the insulin resistance atherosclerosis study. Am J Clin Nutr 85:1495–1502Google Scholar
  21. 21.
    Nuttall FQ, Gannon MC (1991) Plasma glucose and insulin response to macronutrients in nondiabetic and NIDDM subjects. Diabetes Care 14:824–838CrossRefGoogle Scholar
  22. 22.
    Onning G, Wallmark A, Persson M, Akesson B, Elmstahl S, Oste R (1999) Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia. Ann Nutr Metab 43:301–309CrossRefGoogle Scholar
  23. 23.
    Orskov C, Wettergren A, Holst JJ (1996) Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol 31:665–670CrossRefGoogle Scholar
  24. 24.
    Rave K, Roggen K, Dellweg S, Heise T, tom Dieck H (2007) Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose. Br J Nutr 98:929–936CrossRefGoogle Scholar
  25. 25.
    Reaven G (2005) Insulin resistance, type 2 diabetes mellitus, and cardiovascular disease: the end of the beginning. Circulation 112:3030–3032CrossRefGoogle Scholar
  26. 26.
    Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473–486Google Scholar
  27. 27.
    Stern SE, Williams K, Ferrannini E, DeFronzo RA, Bogardus C, Stern MP (2005) Identification of individuals with insulin resistance using routine clinical measurements. Diabetes 54: 333–339CrossRefGoogle Scholar
  28. 28.
    Wood PJ, Beer MU, Butler G (2000) Evaluation of role of concentration and molecular weight of oat beta-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load. Br J Nutr 84:19–23Google Scholar
  29. 29.
    Yokoyama WH, Hudson CA, Knuckles BE, Chiu MC, Sayre RN, Turnlund JR, Schneeman BO (2003) Effect of barley β-glucan in durum wheat pasta on human glycemic response. Cereal Chem 74:293–296CrossRefGoogle Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2009

Authors and Affiliations

  • Hyunsook Kim
    • 1
  • Kim S. Stote
    • 2
  • Kay M. Behall
    • 2
  • Karen Spears
    • 3
  • Bryan Vinyard
    • 4
  • Joan M. Conway
    • 2
  1. 1.Western Regional Research Center, US Dept. of Agriculture, Agricultural Research ServiceAlbanyUSA
  2. 2.Food Components and Health LaboratoryBeltsville Human Nutrition Research Center, US Dept. of Agriculture, Agricultural Research ServiceBeltsvilleUSA
  3. 3.College of Agriculture, Biotechnology and Natural ResourcesUniversity of NevadaRenoUSA
  4. 4.Biometrical Consulting ServiceUS Dept. of Agriculture, Agricultural Research ServiceBeltsvilleUSA

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