Adipocyte fatty acid binding protein during refeeding of female patients with anorexia nervosa
- 137 Downloads
Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important role in fat metabolism linking obesity and the metabolic syndrome. Increasing A-FABP plasma levels were observed during greatest weight loss after bariatric surgery suggesting that A-FABP may indicate changes in fat mass in dynamic situations.
Aim of the study
As there are no data on weight gain, we investigated the effect of refeeding anorexic patients on body composition and A-FABP plasma levels.
Parameters of glucose and lipid metabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in 16 female patients with anorexia nervosa during inpatient weight restoration. Body composition was determined by multifrequency body impedance analysis.
After 28 days, fat mass increased from 4.4 ± 2.5 kg at baseline to 5.5 ± 2.2 kg (P < 0.01), constituting 40% of total weight gain. Conversely, A-FABP concentrations decreased from 32.56 ± 35.59 ng/ml at baseline to 21.27 ± 13.68 ng/ml (P < 0.05), which corresponds to a significant decrease in the proportion of A-FABP per kilogram fat mass from 7.86 ± 5.23 to 4.09 ± 2.12 ng/ml/kg (P ≤ 0.001). Variation in A-FABP plasma concentration was predictive for changes in total cholesterol levels (adjusted r 2 = 0.239; P ≤ 0.05), but not for gain in weight, fat mass, or percent body fat.
The present results indicate that variation in A-FABP plasma levels reflect alterations in nutritional status in patients with anorexia nervosa.
KeywordsA-FABP Weight gain Metabolism Anorexia nervosa
We thank Karin Salzmann for excellent technical assistance.
- 4.Coe NR, Bernlohr DA (1998) Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1391:287–306Google Scholar
- 7.Forbes GB, Kreipe RE, Lipinski BA, Hodgman CH (1984) Body composition changes during recovery from anorexia nervosa: comparison of two dietary regimes. Am J Clin Nutr 40:1137–1145Google Scholar
- 9.Grinspoon S, Thomas L, Miller K, Pitts S, Herzog D, Klibanski A (2001) Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa. Am J Clin Nutr 73:865–869Google Scholar
- 13.Makowski L, Hotamisligil GS (2004) Fatty acid binding proteins—the evolutionary crossroads of inflammatory and metabolic responses. J Nutr 134:2464S–2468SGoogle Scholar
- 15.Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A (2004) Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 89:3486–3495CrossRefGoogle Scholar
- 16.Misra M, Soyka LA, Miller KK, Grinspoon S, Levitsky LL, Klibanski A (2003) Regional body composition in adolescents with anorexia nervosa and changes with weight recovery. Am J Clin Nutr 77:1361–1367Google Scholar
- 18.Orphanidou CI, McCargar LJ, Birmingham CL, Belzberg AS (1997) Changes in body composition and fat distribution after short-term weight gain in patients with anorexia nervosa. Am J Clin Nutr 65:1034–1041Google Scholar
- 21.Probst M, Goris M, Vandereycken W, Van Coppenolle H (2001) Body composition of anorexia nervosa patients assessed by underwater weighing and skinfold-thickness measurements before and after weight gain. Am J Clin Nutr 73:190–197Google Scholar
- 24.Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671Google Scholar
- 30.Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C (2001) Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19–RC21Google Scholar
- 32.Waller EG, Wade AJ, Treasure J, Ward A, Leonard T, Powell-Tuck J (1996) Physical measures of recovery from anorexia nervosa during hospitalised re-feeding. Eur J Clin Nutr 50:165–170Google Scholar