Dietary magnesium intake is related to metabolic syndrome in older Americans
Magnesium (Mg) is an essential cofactor for enzymes involved in glucose and insulin metabolism. Low intakes of dietary magnesium may be linked to greater risk of metabolic syndrome (MS) in older adults.
Aim of the study
The objective of this study was to examine the cross-sectional relationship between dietary Mg intake, metabolic risk factors and MS in elderly adults.
This study was conducted in a sample of 535 (179 men and 356 women) community-living adults aged 60 years and in Boston Massachusetts between the years 1981 and 1984. Dietary Mg intake was assessed by a 3-day food record and categorized by quartiles of dietary intake. The MS was defined based on criteria set by the Third Report of the National Cholesterol Education Program except that body mass index was used in place of waist circumference. Logistic regression analysis was used to examine the association between quartile categories of Mg intake, prevalence of MS and components of the MS. Models were adjusted for age, gender, BMI, race, educational attainment, marital status, smoking status, alcohol intake, exercise, energy intake, percentage of calories from saturated fat, use of antihypertensive or lipid medication.
Mg intake was inversely associated with the MS; those with the highest intake of Mg had significantly lower risk of having MS compared to the lowest quartile of intake (OR: 0.36, 95% CI 0.19–0.69, P for trend 0.002). Significant inverse relationships were observed between Mg intake and BMI (OR: 0.47, 95% CI: 0.22–1.00, P trend = 0.03), and fasting glucose (OR: 0.41, 95% CI 0.22–0.77, P trend = 0.005).
Our study demonstrates that Mg intake is inversely associated with prevalence of the MS in older adults. Older adults should be encouraged to eat foods rich in Mg, such as green vegetables, legumes and whole-grains.
Keywordsdietary magnesium metabolic syndrome older adults
- 1.Allain CC, Poon LS, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20:470–475Google Scholar
- 3.Bo S, Durazzo M, Guidi S, Carello M, Sacerdote C, Silli B, Rosato R, Cassader M, Gentile L, Pagano G (2006) Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr 84:1062–1069Google Scholar
- 4.Corica F, Corsonello A, Ientile R, Cucinotta D, Di Benedetto A, Perticone F, Dominguez LJ, Barbagallo M (2006) Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients. J Am Coll Nutr 25:210–215Google Scholar
- 8.Ford ES, Mokdad AH (2003) Dietary magnesium intake in a national sample of US adults. J Nutr 133:2879–2882Google Scholar
- 9.Giegel JL, Ham AB, Clema W (1975) Manual and semi-automated procedures for measurements of triglycerides in serum. Clin Chem 21:1575–1581Google Scholar
- 12.He W, Sengupta M, Velkoff VA, DeBarros KA (2005) 65+ in the United States: 2005. In Current Population Reports. U.S. Census Bureau, Washington, DC, pp 23–209Google Scholar
- 13.Institute of Medicine (1997) Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy Press, Washington, DCGoogle Scholar
- 14.Lopes-Virella MF, Stone P, Ellis S, Colwell JA (1977) Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem 23:882–884Google Scholar
- 15.Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA (1995) Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J Clin Epidemiol 48:927–940CrossRefGoogle Scholar
- 16.Paolisso G, Passariello N, Pizza G, Marrazzo G, Giunta R, Sgambato S, Varricchio M, D’Onofrio F. (1989a) Dietary magnesium supplements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects. Acta Endocrinol (Copenh) 121:16–20Google Scholar
- 17.Paolisso G, Sgambato S, Gambardella A, Pizza G, Tesauro P, Varricchio M, D’Onofrio F. (1992) Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 55:1161–1167Google Scholar
- 22.Russell RM, Rasmussen H, Lichtenstein AH. (1999) Modified Food Guide Pyramid for people over seventy years of age. J Nutr 129:751–753Google Scholar
- 23.Sahyoun NR, Jacques PF, Zhang XL, Juan W, McKeown NM (2006) Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr 83:124–131Google Scholar
- 29.Yokota K, Kato M, Lister F, Ii H, Hayakawa T, Kikuta T, Kageyama S, Tajima N (2004) Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J Am Coll Nutr 23:506S–509SGoogle Scholar
- 30.Zhu S, Wang Z, Heshka S, Heo M, Faith MS, Heymsfield SB (2002) Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. Am J Clin Nutr 76:743–749Google Scholar