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European Journal of Nutrition

, Volume 47, Issue 2, pp 87–91 | Cite as

Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index

  • Steinar Konradsen
  • Harald Ag
  • Fedon Lindberg
  • Sofie Hexeberg
  • Rolf Jorde
ORIGINAL CONTRIBUTION

Abstract

Background

Based on in vitro studies, it has been hypothesized that 1,25-dihydroxy vitamin D (1,25-vit D) may promote weight gain in humans, but previous studies have demonstrated conflicting results regarding the association between serum 1,25-vit D and body mass index (BMI).

Aim of the study

To evaluate the relation between serum 1,25-vit D and BMI.

Methods

Two thousand one hundred and eighty-seven subjects, recruited from a metabolic and medical lifestyle management clinic, were included in a cross-sectional study. BMI, 25-hydroxy vitamin D (25-OH-vit D) and 1,25-vit D were measured. The cohort was divided according to BMI in five groups (<25, 25–29.9, 30–34.9, 35–39.9 and >39.9 kg/m2). Statistical analyses were performed with multiple linear regression models. Age and gender were used as explanatory covariates.

Results

With increasing BMI group, there was a significant decrease in both serum 25-OH-vit D and 1,25-vit D (P < 0.001). Those with BMI > 39.9 kg/m2 had 24% lower serum 25-OH-vit D levels and 18 % lower 1,25-vit D levels than those with BMI < 25 kg/m2.

Conclusions

There is an inverse association between BMI and the serum levels of 25-OH-vit D and 1,25-vit D. This makes it highly unlikely that high levels of circulating 1,25-vit D contribute to the development of obesity.

Keywords

body mass index obesity vitamin D 

References

  1. 1.
    Arunabh S, Pollack S, Yeh J, Aloia JF (2003) Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endo Metab 88:157–161CrossRefGoogle Scholar
  2. 2.
    Bell NH (1985) Vitamin D-endocrine system. J Clin Invest 76:1–6CrossRefGoogle Scholar
  3. 3.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S (1985) Evidence for alteration of the vitamin D endocrine system in obese subjects. J Clin Invest 76:370–373CrossRefGoogle Scholar
  4. 4.
    Clarke AD, Rowbury CS (1985) Removal of lipids before liquid chromatography of vitamin D in serum. Clin Chem 31:657–658Google Scholar
  5. 5.
    Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR (1981) Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr 34:2359–2363Google Scholar
  6. 6.
    Hey H, Stokholm KH, Lund B, Lund B, Sørensen OH (1982) Vitamin D deficiency in obese patients and changes in circulating vitamin D metabolites following jejunoileal bypass. Int J Obes 6:473–479Google Scholar
  7. 7.
    Jongen MJ, Van Ginkel FC, van der Vijgh WJ, Kuiper S, Netelenbos JC, Lips P (1984) An international comparison of vitamin D metabolite measurements. Clin Chem 30:399–403Google Scholar
  8. 8.
    Kamycheva E, Joakimsen RM, Jorde R (2003) Intakes of calcium and vitamin D predict body mass index in the population of northern Norway. J Nutr 133:102–106Google Scholar
  9. 9.
    Kamycheva E, Sundsfjord J, Jorde R (2004) Serum parathyroid hormone as a predictor of increased body mass index. The fifth Tromsø Study. Eur J Endocrinol 151:167–172CrossRefGoogle Scholar
  10. 10.
    Kerstetter J, Caballero B, O’Brien K, Wurtman R, Allen L (1991) Mineral homeostasis in obesity: effects of euglycemic hyperinsulinemia. Metabolism 40:707–713CrossRefGoogle Scholar
  11. 11.
    Kopelman PG (2000) Obesity as a medical problem. Nature 404:635–643Google Scholar
  12. 12.
    Lemann Jr J, Gray RW, Maierhofer WJ, Adams ND (1984) Effect of weight loss on serum 1,25-(OH)2-vitamin D concentrations in adults: a preliminary report. Calsif Tissue Int 36:139–144CrossRefGoogle Scholar
  13. 13.
    Liel Y, Enoch U, Shary J, Hollis BW, Bell NH (1984) Low circulating vitamin D in obesity. Calsif Tissue Int 43:199–201CrossRefGoogle Scholar
  14. 14.
    Loos RJ, Bouchard C (2003) Obesity—is it a genetic disorder? J Intern Med 254:401–425CrossRefGoogle Scholar
  15. 15.
    Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA (2004) The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endo Metab 89:1196–1199CrossRefGoogle Scholar
  16. 16.
    Reinhardt TA, Horst RL, Orf JW, Hollis BW (1984) A microassay for 1,25-dihydroxy vitamin D not requiring high performance liquid chromatography: Application to clinical studies. J Clin Endocrinol Metab 58:91–97CrossRefGoogle Scholar
  17. 17.
    Shi H, Norman AW, Okamura WH, Anintida S, Zemel MB (2002) 1α,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 16:1808–1810Google Scholar
  18. 18.
    Shi H, Norman W, Okamura WH, Sen A, Zemel MB (2001) 1α,25-dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J 15:2751–2753Google Scholar
  19. 19.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690–693Google Scholar
  20. 20.
    Zamboni G, Soffiati M, Giavarina D, Tato L (1988) Mineral metabolism in obese children. Acta Paediatr Scand 77:741–746CrossRefGoogle Scholar
  21. 21.
    Zittermann A (2003) Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 89:552–572CrossRefGoogle Scholar
  22. 22.
    Zittermann A (2006) Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92:39–48CrossRefGoogle Scholar

Copyright information

© Spinger 2008

Authors and Affiliations

  • Steinar Konradsen
    • 1
  • Harald Ag
    • 1
  • Fedon Lindberg
    • 2
  • Sofie Hexeberg
    • 2
  • Rolf Jorde
    • 1
    • 3
  1. 1.Institute of Clinical MedicineUniversity of TromsøTromsøNorway
  2. 2.Dr. Fedon Lindberg’s ClinicOsloNorway
  3. 3.Dept. of Internal Medicine BUniversity Hospital of North NorwayTromsøNorway

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