European Journal of Nutrition

, 46:406

Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?

  • Mark S. Segal
  • Elizabeth Gollub
  • Richard J. Johnson
ORIGINAL CONTRIBUTION

Abstract

The glycemic index (G.I.) is a means for categorizing carbohydrates based on their ability to raise blood glucose, subsequently this index has been popularized as a way for selecting foods to reduce the risk for obesity, diabetes, and cardiovascular disease. We suggest that the G.I. is better aimed at identifying foods that stimulate insulin secretion rather than foods that stimulate insulin resistance. In this regard, fructose has a low G.I. but may be causally linked with the obesity and cardiovascular disease epidemic. The reported association of high G.I. with cardiovascular disease may be due to the association of sugar intake which contains fructose, but which has a high G.I. due to its glucose content. We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population.

Keywords

cardiovascular disease fructose metabolic syndrome obesity uric acid 

References

  1. 1.
    (1991) World and U.S. corn sweeteners—1990/1991 world corn sweetener production, consumption, prices. In: Economic Research Service (ed) Situation and Outlook Report: Sugar and Sweetener. US Department of AgricultureGoogle Scholar
  2. 2.
    Ackerman Z, Oron-Herman M, Grozovski M, Rosenthal T, Pappo O, Link G, Sela BA (2005) Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 45:1012–1018Google Scholar
  3. 3.
    Agatston A (2003) The south beach diet: the delicious, doctor-designed, foolproof plan for fast and healthy weight loss. St. Martin’s Press, New YorkGoogle Scholar
  4. 4.
    Alper AB Jr, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL (2005) Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension 45:34–38Google Scholar
  5. 5.
    Amano Y, Kawakubo K, Lee JS, Tang AC, Sugiyama M, Mori K (2004) Correlation between dietary glycemic index and cardiovascular disease risk factors among Japanese women. Eur J Clin Nutr 58:1472–1478Google Scholar
  6. 6.
    Avena NM, Rada P, Hoebel BG (2007) Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev Epub ahead of printGoogle Scholar
  7. 7.
    Bais R, James HM, Rofe AM, Conyers RA (1985) The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. Biochem J 230:53–60Google Scholar
  8. 8.
    Bantle JP, Raatz SK, Thomas W, Georgopoulos A (2000) Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 72:1128–1134Google Scholar
  9. 9.
    Baret G, Peyronnet J, Grassi-Kassisse D, Dalmaz Y, Wiernsperger N, Geloen A (2002) Increased intraabdominal adipose tissue mass in fructose fed rats: correction by metformin. Exp Clin Endocrinol Diabetes 110:298–303Google Scholar
  10. 10.
    Beck-Nielsen H, Pedersen O, Lindskov HO (1980) Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr 33:273–278Google Scholar
  11. 11.
    Bell RC, Carlson JC, Storr KC, Herbert K, Sivak J (2000) High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. Br J Nutr 84:575–582Google Scholar
  12. 12.
    Bidlingmeyer I, Burnier M, Bidlingmeyer M, Waeber B, Brunner HR (1996) Isolated office hypertension: a prehypertensive state? J Hypertens 14:327–332Google Scholar
  13. 13.
    Blakely SR, Hallfrisch J, Reiser S, Prather ES (1981) Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats. J Nutr 111:307–314Google Scholar
  14. 14.
    Bode JC, Zelder O, Rumpelt HJ, Wittkamp U (1973) Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat. Eur J Clin Invest 3:436–441Google Scholar
  15. 15.
    Brands MW, Garrity CA, Holman MG, Keen HL, Alonso-Galicia M, Hall JE (1994) High-fructose diet does not raise 24-h mean arterial pressure in rats. Am J Hypertens 7:104–109Google Scholar
  16. 16.
    Bray GA, Nielsen SJ, Popkin BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79:537–543Google Scholar
  17. 17.
    Burant CF, Saxena M (1994) Rapid reversible substrate regulation of fructose transporter expression in rat small intestine and kidney. Am J Physiol 267:G71–G79Google Scholar
  18. 18.
    Butler R, Morris AD, Belch JJ, Hill A, Struthers AD (2000) Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 35:746–751Google Scholar
  19. 19.
    Cardillo C, Kilcoyne CM, Cannon RO 3rd, Quyyumi AA, Panza JA (1997) Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients. Hypertension 30:57–63Google Scholar
  20. 20.
    Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM (2007) Xanthine oxidoreductase is a regulator of adipogenesis and PPAR[gamma] activity. Cell Metabolism 5:115–128Google Scholar
  21. 21.
    Clausen T, Slott M, Solvoll K, Drevon CA, Vollset SE, Henriksen T (2001) High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia. Am J Obstet Gynecol 185:451–458Google Scholar
  22. 22.
    Cunha TS, Farah V, Paulini J, Pazzine M, Elased KM, Marcondes FK, Claudia Irigoyen M, De Angelis K, Mirkin LD, Morris M (2007) Relationship between renal and cardiovascular changes in a murine model of glucose intolerance. Regul Pept 139:1–4Google Scholar
  23. 23.
    D’Angelo G, Elmarakby AA, Pollock DM, Stepp DW (2005) Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats. Hypertension 46:806–811Google Scholar
  24. 24.
    Dennison BA, Rockwell HL, Baker SL (1997) Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity. Pediatrics 99:15–22Google Scholar
  25. 25.
    Doehner W, Anker SD (2005) Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure? Heart 91:707–709Google Scholar
  26. 26.
    Doehner W, Schoene N, Rauchhaus M, Leyva-Leon F, Pavitt DV, Reaveley DA, Schuler G, Coats AJ, Anker SD, Hambrecht R (2002) Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies. Circulation 105:2619–2624Google Scholar
  27. 27.
    Dresser C (1979) Food consumption profiles of white and black persons aged 1–74 years: United States 1971–1974. Data from the National Health survey, DHEW Publication No (PHS) 79–1658. National Center for Health Statistics, Hyattsville, MDGoogle Scholar
  28. 28.
    Drewnowski A, Bellisle F (2007) Liquid calories, sugar, and body weight. Am J Clin Nutr 85:651–661Google Scholar
  29. 29.
    Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, Vollenweider P, Pedrazzini T, Nicod P, Thorens B, Scherrer U (2001) Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 104:342–345Google Scholar
  30. 30.
    Dwyer JT, Evans M, Stone EJ, Feldman HA, Lytle L, Hoelscher D, Johnson C, Zive M, Yang M (2001) Adolescents’ eating patterns influence their nutrient intakes. J Am Diet Assoc 101:798–802Google Scholar
  31. 31.
    Dyer AR, Liu K, Walsh M, Kiefe C, Jacobs DR Jr, Bild DE (1999) Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study. Coronary artery risk development in (young) adults. J Hum Hypertens 13:13–21Google Scholar
  32. 32.
    Ebbeling CB, Feldman HA, Osganian SK, Chomitz VR, Ellenbogen SJ, Ludwig DS (2006) Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics 117:673–680Google Scholar
  33. 33.
    El Solh AA, Saliba R, Bosinski T, Grant BJ, Berbary E, Miller N (2006) Allopurinol improves endothelial function in sleep apnoea: a randomised controlled study. Eur Respir J 27:997–1002Google Scholar
  34. 34.
    Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76:911–922Google Scholar
  35. 35.
    Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy L (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 54:1907–1913Google Scholar
  36. 36.
    Farah V, Elased KM, Chen Y, Key MP, Cunha TS, Irigoyen MC, Morris M (2006) Nocturnal hypertension in mice consuming a high fructose diet. Auton Neurosci 130:41–50Google Scholar
  37. 37.
    Farquharson CA, Butler R, Hill A, Belch JJ, Struthers AD (2002) Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation 106:221–226Google Scholar
  38. 38.
    Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, Johnson RJ (2004) Hypothesis: uric acid, nephron number, and the pathogenesis of essential hypertension 66:281–287Google Scholar
  39. 39.
    Fiaschi E, Baggio B, Favaro S, Antonello A, Camerin E, Todesco S, Borsatti A (1977) Fructose-induced hyperuricemia in essential hypertension. Metabolism 26:1219–1223Google Scholar
  40. 40.
    Forman JP, Choi H, Curhan GC (2007) Plasma uric acid level and risk for incident hypertension among men. J Am Soc Nephrol 18:287–292Google Scholar
  41. 41.
    Foster-Powell K, Holt SH, Brand-Miller JC (2002) International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5–56Google Scholar
  42. 42.
    Fox IH, Kelley WN (1972) Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism 21:713–721Google Scholar
  43. 43.
    Fukuda H, Dyck J, Stout J (2002) Sweetener Policies in Japan. In: Economic Research Service (ed) Situation and outlook report: sugar and sweetener. US Department of AgricultureGoogle Scholar
  44. 44.
    Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752–1761Google Scholar
  45. 45.
    Gaby AR (2005) Adverse effects of dietary fructose. Altern Med Rev 10:294–306Google Scholar
  46. 46.
    Galbusera C, Orth P, Fedida D, Spector T (2006) Superoxide radical production by allopurinol and xanthine oxidase. Biochem Pharmacol 71:1747–1752Google Scholar
  47. 47.
    Gao X, Qi L, Qiao N, Choi HK, Curhan G, Tucker KL, Ascherio A (2007) Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension 50:306–312Google Scholar
  48. 48.
    George J, Carr E, Davies J, Belch JJ, Struthers A (2006) High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 114:2508–2516Google Scholar
  49. 49.
    Gross LS, Li L, Ford ES, Liu S (2004) Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 79:774–779Google Scholar
  50. 50.
    Guthikonda S, Sinkey C, Barenz T, Haynes WG (2003) Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers. Circulation 107:416–421Google Scholar
  51. 51.
    Haley S, Reed J, Biing-Hwan L, Cook A (2005) Sweetener consumption in the United States: distribution by demographic and product characteristics. In: Economic Research Service (ed) Situation and outlook report: sugar and sweetener. US Department of AgricultureGoogle Scholar
  52. 52.
    Hallfrisch J, Ellwood KC, Michaelis OEt, Reiser S, O’Dorisio TM, Prather ES (1983) Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr 113:1819–1826Google Scholar
  53. 53.
    Hallfrisch J, Reiser S, Prather ES (1983) Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose. Am J Clin Nutr 37:740–748Google Scholar
  54. 54.
    Havel PJ (2005) Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63:133–157Google Scholar
  55. 55.
    Herbert KL, Sivak JG, Bell RC (1999) Effect of diabetes and fructose/non-fructose diet on the optical quality (cataracts) of the rat lens. Curr Eye Res 19:305–312Google Scholar
  56. 56.
    Howard BV, Wylie-Rosett J (2002) Sugar and cardiovascular disease: a statement for healthcare professionals from the committee on nutrition of the council on nutrition, physical activity, and metabolism of the American heart association. Circulation 106:523–527Google Scholar
  57. 57.
    Hsieh PS, Huang WC (2001) Neonatal chemical sympathectomy attenuates fructose-induced hypertriglyceridemia and hypertension in rats. Chin J Physiol 44:25–31Google Scholar
  58. 58.
    Huang BW, Chiang MT, Yao HT, Chiang W (2004) The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes Metab 6:120–126Google Scholar
  59. 59.
    Hung CT (1989) Effects of high-fructose (90%) corn syrup on plasma glucose, insulin, and C-peptide in non-insulin-dependent diabetes mellitus and normal subjects. Taiwan Yi Xue Hui Za Zhi 88:883–885Google Scholar
  60. 60.
    Hunt SC, Stephenson SH, Hopkins PN, Williams RR (1991) Predictors of an increased risk of future hypertension in Utah. A screening analysis Hypertension 17:969–976Google Scholar
  61. 61.
    Imazu M, Yamamoto H, Toyofuku M, Sumii K, Okubo M, Egusa G, Yamakido M, Kohno N (2001) Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study. Hypertens Res 24:531–536Google Scholar
  62. 62.
    Israel KD, Michaelis OEt, Reiser S, Keeney M (1983) Serum uric acid, inorganic phosphorus, and glutamic-oxalacetic transaminase and blood pressure in carbohydrate-sensitive adults consuming three different levels of sucrose. Ann Nutr Metab 27:425–435CrossRefGoogle Scholar
  63. 63.
    Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV (1981) Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34:362–366Google Scholar
  64. 64.
    Jequier E, Tappy L (1999) Regulation of body weight in humans. Physiol Rev 79:451–480Google Scholar
  65. 65.
    Johnson RJ, Gordon KL, Suga S, Duijvestijn AM, Griffin K, Bidani A (1999) Renal injury and salt-sensitive hypertension after exposure to catecholamines. Hypertension 34:151–159Google Scholar
  66. 66.
    Johnson RJ, Herrera-Acosta J, Schreiner GF, Rodriguez-Iturbe B (2002) Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med 346:913–923Google Scholar
  67. 67.
    Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M (2003) Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41:1183–1190Google Scholar
  68. 68.
    Jossa F, Farinaro E, Panico S, Krogh V, Celentano E, Galasso R, Mancini M, Trevisan M (1994) Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens 8:677–681Google Scholar
  69. 69.
    Jurgens H, Haass W, Castaneda TR, Schurmann A, Koebnick C, Dombrowski F, Otto B, Nawrocki AR, Scherer PE, Spranger J, Ristow M, Joost HG, Havel PJ, Tschop MH (2005) Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res 13:1146–1156Google Scholar
  70. 70.
    Kang DH, Park SK, Lee IK, Johnson RJ (2005) Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 16:3553–3562Google Scholar
  71. 71.
    Katakam PV, Hoenig M, Ujhelyi MR, Miller AW (2000) Cytochrome P450 activity and endothelial dysfunction in insulin resistance. J Vasc Res 37:426–434Google Scholar
  72. 72.
    Katakam PV, Ujhelyi MR, Hoenig ME, Miller AW (1998) Endothelial dysfunction precedes hypertension in diet-induced insulin resistance. Am J Physiol 275:R788–R792Google Scholar
  73. 73.
    Kerr GR, Amante P, Decker M, Callen PW (1983) Supermarket sales of high-sugar products in predominantly Black, Hispanic, and white census tracts of Houston, Texas. Am J Clin Nutr 37:622–631Google Scholar
  74. 74.
    Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Krotova K, Block ER, Prabhakar S, Johnson RJ (2005) Hyperuricemia induces endothelial dysfunction. Kidney Int 67:1739–1742Google Scholar
  75. 75.
    Korieh A, Crouzoulon G (1991) Dietary regulation of fructose metabolism in the intestine and in the liver of the rat. Duration of the effects of a high fructose diet after the return to the standard diet. Arch Int Physiol Biochim Biophys 99:455–460Google Scholar
  76. 76.
    Kranz S, Smiciklas-Wright H, Siega-Riz AM, Mitchell D (2005) Adverse effect of high added sugar consumption on dietary intake in American preschoolers. J Pediatr 146:105–111Google Scholar
  77. 77.
    Krishnan E, Kwoh CK, Schumacher HR, Kuller L (2007) Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension 49:298–303Google Scholar
  78. 78.
    Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE (2005) Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee. Arterioscler Thromb Vasc Biol 25:478–479Google Scholar
  79. 79.
    Kuzkaya N, Weissmann N, Harrison DG, Dikalov S (2005) Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Biochem Pharmacol 70:343–354Google Scholar
  80. 80.
    Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H (2002) Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 106:3073–3078Google Scholar
  81. 81.
    Le KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, Boesch C, Ravussin E, Tappy L (2006) A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 84:1374–1379Google Scholar
  82. 82.
    Le KA, Tappy L (2006) Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 9:469–475Google Scholar
  83. 83.
    Liese AD, Schulz M, Fang F, Wolever TM, D’Agostino RB Jr, Sparks KC, Mayer-Davis EJ (2005) Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study. Diabetes Care 28:2832–2838Google Scholar
  84. 84.
    Lingelbach LB, McDonald RB (2000) Description of the long-term lipogenic effects of dietary carbohydrates in male Fischer 344 rats. J Nutr 130:3077–3084Google Scholar
  85. 85.
    Liu S, Manson JE (2001) Dietary carbohydrates, physical inactivity, obesity, and the ‘metabolic syndrome’ as predictors of coronary heart disease. Curr Opin Lipidol 12:395–404Google Scholar
  86. 86.
    Liu S, Manson JE, Stampfer MJ, Holmes MD, Hu FB, Hankinson SE, Willett WC (2001) Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr 73:560–566Google Scholar
  87. 87.
    Liu S, Willett WC, Stampfer MJ, Hu FB, Franz M, Sampson L, Hennekens CH, Manson JE (2000) A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 71:1455–1461Google Scholar
  88. 88.
    Ludwig DS, Peterson KE, Gortmaker SL (2001) Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 357:505–508Google Scholar
  89. 89.
    Macdonald I (1966) Influence of fructose and glucose on serum lipid levels in men and pre- and postmenopausal women. Am J Clin Nutr 18:369–372Google Scholar
  90. 90.
    Maenpaa PH, Raivio KO, Kekomaki MP (1968) Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis. Science 161:1253–1254Google Scholar
  91. 91.
    Mancia G, Facchetti R, Bombelli M, Grassi G, Sega R (2006) Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure. Hypertension 47:846–853Google Scholar
  92. 92.
    Manitius J, Biedunkiewicz B, Kustosz J, Rutkowski B (1996) The relationship between insulin, glucose and serum uric acid and their contribution to the progression of renal damage in patients with primary glomerulonephritis. J Int Med Res 24:449–453Google Scholar
  93. 93.
    Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML (2003) Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 42:474–480Google Scholar
  94. 94.
    Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ (2001) Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 38:1101–1106Google Scholar
  95. 95.
    Mellen PB, Bleyer AJ, Erlinger TP, Evans GW, Nieto FJ, Wagenknecht LE, Wofford MR, Herrington DM (2006) Serum Uric Acid Predicts Incident Hypertension in a Biethnic Cohort. The Atherosclerosis Risk in Communities Study. HypertensionGoogle Scholar
  96. 96.
    Mercuro G, Vitale C, Cerquetani E, Zoncu S, Deidda M, Fini M, Rosano GM (2004) Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk. Am J Cardiol 94:932–935Google Scholar
  97. 97.
    Miatello R, Cruzado M, Risler N (2004) Mechanisms of cardiovascular changes in an experimental model of syndrome X and pharmacological intervention on the renin-angiotensin-system. Curr Vasc Pharmacol 2:371–377Google Scholar
  98. 98.
    Miatello R, Risler N, Gonzalez S, Castro C, Ruttler M, Cruzado M (2002) Effects of enalapril on the vascular wall in an experimental model of syndrome X. Am J Hypertens 15:872–878Google Scholar
  99. 99.
    Miller JC (1994) Importance of glycemic index in diabetes. Am J Clin Nutr 59:747S–752SGoogle Scholar
  100. 100.
    Moore MC, Cherrington AD, Mann SL, Davis SN (2000) Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab 85:4515–4519Google Scholar
  101. 101.
    Morris RC Jr, Nigon K, Reed EB (1978) Evidence that the severity of depletion of inorganic phosphate determines the severity of the disturbance of adenine nucleotide metabolism in the liver and renal cortex of the fructose-loaded rat. J Clin Invest 61:209–220CrossRefGoogle Scholar
  102. 102.
    Nagahama K, Inoue T, Iseki K, Touma T, Kinjo K, Ohya Y, Takishita S (2004) Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. Hypertens Res 27:835–841Google Scholar
  103. 103.
    Nair S, V PC, Arnold C, Diehl AM (2003) Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals. Am J Gastroenterol 98:466–470Google Scholar
  104. 104.
    Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ (2006) A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 290:F625–F631Google Scholar
  105. 105.
    Nakagawa T, Tuttle KR, Short RA, Johnson RJ (2006) Fructose-induced hyperuricemia as a casual mechanism for the epidemic of the metabolic syndrome. Nature Clinical Practice Nephrology 1:80–86Google Scholar
  106. 106.
    Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K (2003) Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol 18:523–530Google Scholar
  107. 107.
    Nielsen SJ, Popkin BM (2004) Changes in beverage intake between 1977 and 2001. Am J Prev Med 27:205–210Google Scholar
  108. 108.
    Nishimoto Y, Tomida T, Matsui H, Ito T, Okumura K (2002) Decrease in renal medullary endothelial nitric oxide synthase of fructose-fed, salt-sensitive hypertensive rats. Hypertension 40:190–194Google Scholar
  109. 109.
    Oh K, Hu FB, Cho E, Rexrode KM, Stampfer MJ, Manson JE, Liu S, Willett WC (2005) Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women. Am. J. Epidemiol. 161:161–169Google Scholar
  110. 110.
    Osei K, Bossetti B (1989) Dietary fructose as a natural sweetener in poorly controlled type 2 diabetes: a 12-month crossover study of effects on glucose, lipoprotein and apolipoprotein metabolism. Diabet Med 6:506–511CrossRefGoogle Scholar
  111. 111.
    Pelaez LI, Manriquez MC, Nath KA, Romero JC, Juncos LA (2003) Low-dose angiotensin II enhances pressor responses without causing sustained hypertension. Hypertension 42:798–801Google Scholar
  112. 112.
    Perheentupa J, Raivio K (1967) Fructose-induced hyperuricaemia. Lancet 2:528–531Google Scholar
  113. 113.
    Perlstein TS, Gumieniak O, Williams GH, Sparrow D, Vokonas PS, Gaziano M, Weiss ST, Litonjua AA (2006) Uric acid and the development of hypertension: the normative aging study. Hypertension 48:1031–1036Google Scholar
  114. 114.
    Pi-Sunyer FX (2002) Glycemic index and disease. Am J Clin Nutr 76:290S–298SGoogle Scholar
  115. 115.
    Pinkney JH, Stehouwer CD, Coppack SW, Yudkin JS (1997) Endothelial dysfunction: cause of the insulin resistance syndrome. Diabetes 46(Suppl 2):S9–S13Google Scholar
  116. 116.
    Quiroz Y, Pons H, Gordon KL, Rincon J, Chavez M, Parra G, Herrera-Acosta J, Gomez-Garre D, Largo R, Egido J, Johnson RJ, Rodriguez-Iturbe B (2001) Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition. Am J Physiol Renal Physiol 281:F38–F47Google Scholar
  117. 117.
    Raatz SK, Torkelson CJ, Redmon JB, Reck KP, Kwong CA, Swanson JE, Liu C, Thomas W, Bantle JP (2005) Reduced glycemic index and glycemic load diets do not increase the effects of energy restriction on weight loss and insulin sensitivity in obese men and women. J Nutr 135:2387–2391Google Scholar
  118. 118.
    Raben A, Macdonald I, Astrup A (1997) Replacement of dietary fat by sucrose or starch: effects on 14 d ad libitum energy intake, energy expenditure and body weight in formerly obese and never-obese subjects. Int J Obes Relat Metab Disord 21:846–859Google Scholar
  119. 119.
    Raben A, Vasilaras TH, Moller AC, Astrup A (2002) Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 76:721–729Google Scholar
  120. 120.
    Rajasekar P, Anuradha CV (2007) Fructose-induced hepatic gluconeogenesis: effect of L-carnitine. Life Sci 80:1176–1183Google Scholar
  121. 121.
    Reiser S, Powell AS, Scholfield DJ, Panda P, Ellwood KC, Canary JJ (1989) Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch. Am J Clin Nutr 49:832–839Google Scholar
  122. 122.
    Reyes AJ, Leary WP (2002) The ALLHAT and the cardioprotection conferred by diuretics in hypertensive patients: a connection with uric acid? Cardiovasc Drugs Ther 16:485–487Google Scholar
  123. 123.
    Rizkalla SW, Bellisle F, Slama G (2002) Health benefits of low glycaemic index foods, such as pulses, in diabetic patients and healthy individuals. Br J Nutr 88(Suppl 3):S255–S262Google Scholar
  124. 124.
    Roberts SB, Heyman MB (2000) Dietary composition and obesity: do we need to look beyond dietary fat? J Nutr 130:267SGoogle Scholar
  125. 125.
    Rodriguez-Iturbe B, Pons H, Quiroz Y, Gordon K, Rincon J, Chavez M, Parra G, Herrera-Acosta J, Gomez-Garre D, Largo R, Egido J, Johnson RJ (2001) Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure. Kidney Int 59:2222–2232Google Scholar
  126. 126.
    Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J, Johnson RJ, Pons HA (2002) Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol 282:F191–F201Google Scholar
  127. 127.
    Roy D, Perreault M, Marette A (1998) Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent. Am J Physiol 274:E692–E699Google Scholar
  128. 128.
    Rutkowski B, Tylicki L, Manitius J, Lysiak-Szydlowska W (1999) Hypertensive nephropathy - an increasing clinical problem. Miner Electrolyte Metab 25:65–68Google Scholar
  129. 129.
    Sanchez-Lozada LG L-MR, Soto V, Tapia E, Avila-Casado C, Bautista R, Nakawaga T, Franco M, Johnson RJ (2007) Low fructose caloric intake concomitant to hyperuricemia induces hyperinsulinemia and renal structural damage in rats. J Am Soc Nephrol (in press) (abstract)Google Scholar
  130. 130.
    Sanchez-Lozada LG, Tapia E, Jimenez A, Bautista P, Cristobal M, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M (2007) Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 292:F423–F429Google Scholar
  131. 131.
    Santos CX, Anjos EI, Augusto O (1999) Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Biophys 372:285–294Google Scholar
  132. 132.
    Sato Y, Ito T, Udaka N, Kanisawa M, Noguchi Y, Cushman SW, Satoh S (1996) Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets. Tissue Cell 28:637–643Google Scholar
  133. 133.
    Sautin YY, Nakagawa T, Zharikov S, Johnson RJ (2007) Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell PhysiolGoogle Scholar
  134. 134.
    Scarpace PJ, Matheny M, Tumer N, Cheng KY, Zhang Y (2005) Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia 48:1075–1083Google Scholar
  135. 135.
    Schulze MB, Manson JE, Ludwig DS, Colditz GA, Stampfer MJ, Willett WC, Hu FB (2004) Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. Jama 292:927–934Google Scholar
  136. 136.
    Selby JV, Friedman GD, Quesenberry CP Jr (1990) Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries. Am J Epidemiol 131:1017–1027Google Scholar
  137. 137.
    Shafrir E, Orevi M (1984) Response of hepatic fructokinase to long-term sucrose diets and diabetes in spiny mice, albino mice and rats. Comp Biochem Physiol B 78:493–498Google Scholar
  138. 138.
    Shankar A, Klein R, Klein BE, Nieto FJ (2006) The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study. J Hum Hypertens 20(12):937–945Google Scholar
  139. 139.
    Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD (1998) Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes 47:867–873Google Scholar
  140. 140.
    Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD (2002) Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes 51:469–478Google Scholar
  141. 141.
    Siu YP, Leung KT, Tong MK, Kwan TH (2006) Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis 47:51–59Google Scholar
  142. 142.
    Song D, Hutchings S, Pang CC (2005) Chronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in rats. Eur J Pharmacol 508:205–210Google Scholar
  143. 143.
    Stavric B, Johnson WJ, Clayman S, Gadd RE, Chartrand A (1976) Effect of fructose administration on serum urate levels in the uricase inhibited rat. Experientia 32:373–374Google Scholar
  144. 144.
    Stewart T, Jung FF, Manning J, Vehaskari VM (2005) Kidney immune cell infiltration and oxidative stress contribute to prenatally programmed hypertension. Kidney Int 68:2180–2188Google Scholar
  145. 145.
    Stirpe F, Della Corte E, Bonetti E, Abbondanza A, Abbati A, De Stefano F (1970) Fructose-induced hyperuricaemia. Lancet 2:1310–1311Google Scholar
  146. 146.
    Sundstrom J, Sullivan L, D’Agostino RB, Levy D, Kannel WB, Vasan RS (2005) Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension 45:28–33Google Scholar
  147. 147.
    Swanson JE, Laine DC, Thomas W, Bantle JP (1992) Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 55:851–856Google Scholar
  148. 148.
    Takagi Y, Kashiwagi A, Tanaka Y, Asahina T, Kikkawa R, Shigeta Y (1995) Significance of fructose-induced protein oxidation and formation of advanced glycation end product. J. Diabetes Complications 9:87–91Google Scholar
  149. 149.
    Taniguchi Y, Hayashi T, Tsumura K, Endo G, Fujii S, Okada K (2001) Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: the Osaka Health Survey. J Hypertens 19:1209–1215Google Scholar
  150. 150.
    Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D’Alessio D, Havel PJ (2004) Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89:2963–2972Google Scholar
  151. 151.
    The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977–986Google Scholar
  152. 152.
    Thorburn AW, Storlien LH, Jenkins AB, Khouri S, Kraegen EW (1989) Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr 49:1155–1163Google Scholar
  153. 153.
    Tokita Y, Hirayama Y, Sekikawa A, Kotake H, Toyota T, Miyazawa T, Sawai T, Oikawa S (2005) Fructose ingestion enhances atherosclerosis and deposition of advanced glycated end-products in cholesterol-fed rabbits. J Atheroscler Thromb 12:260–267Google Scholar
  154. 154.
    United Kingdom Prospective Diabetes Study (UKPDS) (1995) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for 3 years. BMJ 310:83–88Google Scholar
  155. 155.
    Vasdev S, Gill V, Parai S, Longerich L, Gadag V (2002) Dietary vitamin E and C supplementation prevents fructose induced hypertension in rats. Mol Cell Biochem 241:107–114Google Scholar
  156. 156.
    Verma S, Bhanot S, McNeill JH (1999) Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension. Eur J Pharmacol 373:R1–R4Google Scholar
  157. 157.
    Virdis A, Ghiadoni L, Sudano I, Buralli S, Salvetti G, Taddei S, Salvetti A (2002) Endothelial function in hypertension: role of gender. J Hypertens Suppl 20:S11–S16Google Scholar
  158. 158.
    Virkamaki A, Korsheninnikova E, Seppala-Lindroos A, Vehkavaara S, Goto T, Halavaara J, Hakkinen AM, Yki-Jarvinen H (2001) Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50:2337–2343Google Scholar
  159. 159.
    Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR (2003) Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 105:425–430CrossRefGoogle Scholar
  160. 160.
    Waring WS, McKnight JA, Webb DJ, Maxwell SR (2006) Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers. Diabetes 55:3127–3132Google Scholar
  161. 161.
    Watanabe S, Kang DH, Feng L, Nakagawa T, Kanellis J, Lan H, Mazzali M, Johnson RJ (2002) Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 40:355–360Google Scholar
  162. 162.
    Weiser MM, Quill H, Isselbacher KJ (1971) Effects of diet on rat intestinal soluble hexokinase and fructokinase activities. Am J Physiol 221:844–849Google Scholar
  163. 163.
    Wexler BC (1982) Allantoxanamide-induced myocardial necrosis in Sprague-Dawley vs spontaneously hypertensive rats. Proc Soc Exp Biol Med 170:476–485Google Scholar
  164. 164.
    Wexler BC, Greenberg BP (1977) Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis. Metabolism 26:1309–1320Google Scholar
  165. 165.
    Willett W, Manson J, Liu S (2002) Glycemic index, glycemic load, and risk of type 2 diabetes. Am J Clin Nutr 76:274S–280SGoogle Scholar
  166. 166.
    Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC (2005) Habitual caffeine intake and the risk of hypertension in women. Jama 294:2330–2335Google Scholar
  167. 167.
    Yadav H, Jain S, Sinha PR (2007) Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 23:62–68Google Scholar
  168. 168.
    Yudkin J (1967) Evolutionary and historical changes in dietary carbohydrates. Am J Clin Nutr 20:108–115Google Scholar
  169. 169.
    Zhao W, Devamanoharan PS, Varma SD (1998) Fructose induced deactivation of glucose-6-phosphate dehydrogenase activity and its prevention by pyruvate: implications in cataract prevention. Free Radic Res 29:315–320Google Scholar
  170. 170.
    Zhao W, Devamanoharan PS, Varma SD (2000) Fructose-mediated damage to lens [alpha]-crystallin: prevention by pyruvate. Biochim Biophys Acta (BBA)-Mol Basis Dis 1500:161–168Google Scholar

Copyright information

© Spinger 2007

Authors and Affiliations

  • Mark S. Segal
    • 1
  • Elizabeth Gollub
    • 1
  • Richard J. Johnson
    • 1
  1. 1.Division of Nephrology, Hypertension and TransplantationUniversity of FloridaGainesvilleUSA

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