Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol
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Oil-based matrices enriched with plant stanol esters lower serum LDL cholesterol. The effects of low-fat milk products have been less thoroughly examined.
Aim of the study
To evaluate the effect of three less explored low-fat milk products enriched with plant stanol esters on serum lipid concentrations in subjects with mild or moderate hypercholesterolemia.
A meta-analysis of four unpublished sub-studies (yoghurt, yoghurt single-shot drink: Studies I and II, or milk). All the sub-studies were randomized, placebo-controlled, double-blind and had a parallel-group design. They were carried out in order to evaluate the effect of low-fat milk products enriched with plant stanol esters on serum lipid concentration. Each stanol-ester-enriched milk product provided 2 g of stanols per day, and in each study the intervention period was 5 weeks. A total of 199 hypercholesterolemic subjects completed the studies.
The pooled treatment difference in total cholesterol was −3.8% (95% CI −6.0 to −1.7, p < 0.001) when stanol was compared to placebo. In LDL cholesterol, the pooled treatment difference was −4.9% (95% CI −7.8 to −1.8, p = 0.002). There were no significant differences between the groups in pooled HDL cholesterol or triacylglycerol concentrations. The results tended to be more pronounced when we were certain that the yoghurt single-shot drink was ingested with lunch, and when the baseline LDL-cholesterol concentration was ≥3.5 mmol/l.
These results imply that low-fat milk products enriched with plant stanol esters lower both total cholesterol and LDL cholesterol statistically significantly in subjects with mild or moderate hypercholesterolemia. The changes tended to relate to the baseline LDL-cholesterol concentration.
Keywordsphytosterols plant stanols hypercholesterolaemia low-fat milk products
- 1.Gylling H, Radhakrishnan R, Miettinen TA (1997) Reduction of cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine. Circulation 96:4226–4231Google Scholar
- 10.Denke MA (1995) Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. Am J Clin Nutr 61:392–396Google Scholar
- 13.Poteau EB, Monnard IE, Piguet-Welsch C, Groux MJA, Sagalowicz L, Berger A (2003) Non-esterified plant sterols solubilized in low-fat milks inhibit cholesterol absorption. Eur J Nutr 42:154–164Google Scholar
- 14.Korpela R, Tuomilehto J, Högström P, Seppo L, Piironen V, Salo-Väänänen P, Toivo J, Lamberg-Allardt C, Kärkkäinen M, Outila T, Sundvall J, Vilkkilä S, Tikkanen MJ (2006) Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. Eur J Clin Nutr 60:633–642CrossRefGoogle Scholar
- 15.Hyun YJ, Kim OY, Kang JB, Lee JH, Jang Y, Liponkoski L, Salo P (2005) Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects. Nutr Res 25:743–753CrossRefGoogle Scholar
- 16.Lääkintöhallitus, 1987. Hyvää ruokaa työpaikalla. Lääkintöhallituksen suositus työpaikalla tapahtuvasta ruokailusta, 24 pGoogle Scholar
- 17.Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin Chem 18:499–502Google Scholar
- 18.Petitti D (1994) Meta-Analysis, decision analysis, cost-effectiveness analysis. Methods for quantitative synthesis in medicine. New York, Oxford University PressGoogle Scholar
- 20.Hallikainen MA, Uusitupa MIJ (1999) Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am J Clin Nutr 69:403–410Google Scholar
- 23.Vanhanen HT, Kajander J, Lehtovirta H, Miettinen TA (1994) Serum levels, absorption efficiency, feacal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin Sci 87:61–67Google Scholar
- 25.Hallikainen MA, Sarkkinen ES, Gylling H, Erkkilä AT, Uusitupa MIJ (2000) Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolemic subjects on a low-fat diet. Eur J Clin Nutr 54: 715–725CrossRefGoogle Scholar
- 26.Ntanios FY, Homma Y, Ushiro S (2002) A spread enriched with plant sterol-esters lowers blood cholesterol and lipoproteins without affecting vitamins A and E in normal and hypercholesterolemic Japanese men and women. J Nutr 132:3650–3655Google Scholar
- 29.Homma Y, Ikeda I, Ishikawa T, Tateno M, Sugano M, Nakamura H (2003) Decrease in plasma low-density lipoprotein cholesterol, apolipoprotein B, cholesteryl ester transfer protein, and oxidized low-density lipoprotein by plant stanol ester-containing spread: a randomized, placebo-controlled trial. Nutrition 19:369–374CrossRefGoogle Scholar