Vitamin A and β-carotene supply of women with gemini or short birth intervals
An adequate supply of vitamin A during pregnancy and breastfeeding plays an important role for development of foetus and neonate, especially in lung development and function.
Aim of the study
Aim of this pilot study was to analyze vitamin A and β-carotene status and to investigate the contribution of nutrition to the vitamin A and β-carotene supply in mother–infant pairs of gemini or births within short birth intervals.
Twenty-nine volunteers aged between 21 and 36 years were evaluated for 48 h after delivery. During this time frame a food frequency protocol considering 3 months retrospective was obtained from all participants. In order to establish overall supply retinol and β-carotene levels were determined in maternal plasma, cord blood and colostrum via HPLC analysis.
Regardless of the high to moderate socio-economic background, 27.6% of participants showed plasma retinol levels below 1.4 μmol/l which can be taken as borderline deficiency. In addition, 46.4% showed retinol intake <66% of RDA and 50.0% did not consume liver at all although liver contributes as a main source for preformed retinol. Despite high total carotenoid intake of 6.9 ± 3.6 mg/d, 20.7% of mothers showed plasma levels <0.5 μmol/l β-carotene. Retinol and β-carotene levels were highly significantly correlated between maternal plasma versus cord blood and colostrum. In addition, significantly lower levels were found in cord blood (31.2 ± 13.0% (retinol), 4.1 ± 1.4% (β-carotene) compared with maternal plasma.
Despite the fact that vitamin A and β-carotene rich food is generally available, risk groups for low vitamin A supply exist in the western world.
Keywordsvitamin A supply gemini births colostrum β-carotene supply cord blood
- 3.Chytil F (1996) Retinoids in lung development. FASEB J 10:986–992Google Scholar
- 4.Atkinson SA (2001) Special nutritional needs of infants for prevention of and recovery from bronchopulmonary dysplasia. J Nutr 131:942–946Google Scholar
- 7.IOM, Institute of Medicine, Food, Nutrition Board (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy Press, Washington, DCGoogle Scholar
- 8.De Pee S, West CE, Permaesih D, Martuti, Muhilal, Hautvast JG (1998) Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and b-carotene in schoolchildren in Indonesia. Am J Clin Nutr 68:1058–1067Google Scholar
- 9.van Lieshout M, West CE, van Breemen RB (2003) Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review. Am J Clin Nutr 77:12–28Google Scholar
- 10.Deutsche Gesellschaft für Ernährung (DGE) (2000) Referenzwerte für die Nährstoffzufuhr. Umschau Braus GmbH, Frankfurt am Main, pp 69–77Google Scholar
- 11.Biesalski HK, Fürst P (1999) Ernährungsmedizin. Georg Thieme Verlag, Stuttgart New York, pp 111–122Google Scholar
- 14.Ross JS, Harvey PW (2003) Contribution of breastfeeding to vitamin A nutrition of infants: a simulation model. Bull World Health Organ 81:80–86Google Scholar
- 15.Huffman S, Rasmusson E, Newman V, O’Gara C (1993) Breastfeeding and the environment. A policy brief from Wellstart International. Birth Gaz 10:17–18Google Scholar
- 16.Pedro RA, Cadelaria LV, Bacos FF, Ungson B, Lanot E (1996) A simplified dietary assessment to identify groups at risk for dietary vitamin A deficiency. Asia Pac J Clin Nutr 5:164–169Google Scholar
- 17.Yeum KJ, Ferland G, Patry J, Russell RM (1998) Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants. J Am Coll Nutr 17:442–447Google Scholar
- 21.Dallaire F, Dewailly E, Shademani R, Laliberte C, Bruneau S, Rhainds M, Blanchet C, Lefebvre M, Ayotte P (2003) Vitamin A concentration in umbilical cord blood of infants from three separate regions of the province of Quebec (Canada). Can J Public Health 94:386–390Google Scholar
- 24.Rondo PH, Abbott R, Rodrigues LC, Tomkins AM (1995) Vitamin A, folate, and iron concentrations in cord and maternal blood of intra-uterine growth retarded and appropriate birth weight babies. Eur J Clin Nutr 49:391–399Google Scholar
- 25.Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements (1998) Vitamin and mineral requirements in human nutrition: report of a joint FAO/WHO expert consultation. Bangkok, Thailand, 21–30 September 1998Google Scholar
- 26.Allen LH (2005) Multiple micronutrients in pregnancy and lactation: an overview. Am J Clin Nutr 81:1206S–1212SGoogle Scholar
- 27.Institute of Medicine FaNB (2000) Dietary reference intakes for vitamin C, vitamin E, selenium und carotinoids. National Academy Press, Washington DCGoogle Scholar
- 30.Canfield LM, Clandinin MT, Davies DP, Fernandez MC, Jackson J, Hawkes J, Goldman WJ, Pramuk K, Reyes H, Sablan B, Sonobe T, Bo X (2003) Multinational study of major breast milk carotenoids of healthy mothers. Eur J Nutr 42:133–141Google Scholar
- 31.Lindqvist A, Andersson S (2004) Cell type-specific expression of beta-carotene 15,15′-mono-oxygenase in human tissues. J Histochem Cytochem 52:491–499Google Scholar