European Journal of Nutrition

, Volume 45, Issue 5, pp 307–310 | Cite as

Is dopamine behind the health benefits of red wine?

  • Rafael de la Torre
  • Maria Isabel Covas
  • Maria Antonia Pujadas
  • Montserrat Fitó
  • Magí Farré
SHORT CONTRIBUTION

Abstract

Background

The contribution of biologically active non-nutrient chemicals to the health benefits of the Mediterranean diet is controversial because of their low dietary concentrations. Hydroxytyrosol is a dopamine metabolite, and also a very active naturally occurring phenol compound in olive oil.

Aim of the study

To examine the disposition of hydroxytyrosol in humans, given that we discovered its presence in red wine in the frame of the study.

Methods

The pharmacokinetics of hydroxytyrosol from two clinical trials, designed to assess the short-term and postprandial effects of moderate doses of wine and olive oil in healthy volunteers, were compared.

Results

Despite a five-fold difference in the doses of hydroxytyrosol administered (0.35 mg for red wine and 1.7 mg for olive oil), urinary recoveries of hydroxytyrosol were higher after red wine administration. An interaction between ethanol and dopamine after red wine ingestion leading to the formation of hydroxytyrosol was observed.

Conclusions

Biological effects after red wine ingestion should be re-examined on the basis of combined hydroxytyrosol concentrations from red wine and dopamine turnover.

Notes

Acknowledgement

Financial support from Instituto Nacional de Investigaciones Agrarias (INIA-MAPA VIN00-027-C3-01) and the PREDIMED network (ISCIII G03/140) is acknowledged.

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Rafael de la Torre
    • 1
    • 2
  • Maria Isabel Covas
    • 3
  • Maria Antonia Pujadas
    • 1
  • Montserrat Fitó
    • 3
  • Magí Farré
    • 1
    • 4
  1. 1.Pharmacology Unit-IMIMInstitut Municipal d’Investigació MèdicaBarcelonaSpain
  2. 2.CEXS-Universitat Pompeu FabraBarcelonaSpain
  3. 3.Lipids and Cardiovascular Epidemiology Research Unit-IMIMInstitut Municipal, d’Investigació MédicaBarcelonaSpain
  4. 4.UDIMAS-Universitat Autónoma de BarcelonaBarcelonaSpain

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