European Journal of Nutrition

, Volume 44, Issue 1, pp 60–62 | Cite as

On the opinion of the European Commission “Scientific Committee on Food” regarding the tolerable upper intake level of vitamin E (2003)

  • Angelo Azzi
  • Regina Brigelius-Flohé
  • Frank Kelly
  • John K. Lodge
  • Nesrin Özer
  • Lester Packer
  • Helmut Sies


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anderson TW, Reid DBW (1974) A double-blind trial of vitamin E in angina pectoris. Am J Clin Nutr 27:1174–1178Google Scholar
  2. 2.
    Bierenbaum ML, et al. (1985) The effect of supplemental vitamin E on serum parameters in diabetics, postcoronary and normal subjects. Nutr Res Int 31:1171–1180Google Scholar
  3. 3.
    Bursell SE, et al. (1999) High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care 22:1245–1251PubMedGoogle Scholar
  4. 4.
    FSA (Food Standards Agency) (2003) Expert Group on Vitamins and Minerals. Risk assessment of vitamin E, pp 145–154Google Scholar
  5. 5.
    Gillilan RE, et al. (1977) Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am Heart J 93:444–449Google Scholar
  6. 6.
    Heart Protection Study Collaborative Group (2002) MRC/BHF Heart protection study of antioxidant vitamin supplementation in 20.536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:23–32CrossRefPubMedGoogle Scholar
  7. 7.
    Kim JM, White RH (1996) Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 77:545–546CrossRefGoogle Scholar
  8. 8.
    Leppälä JM, et al. (2000a) Controlled trial of a-tocopherol and b-carotene supplements on stroke incidence and mortality in male smokers. Arterioscler Thromb Vasc Biol 20:230–235Google Scholar
  9. 9.
    Leppäla JM, et al. (2000b) Vitamin E and beta carotene supplementation in high risk for stroke. A subgroup analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Arch Neurol 57:1503–1509CrossRefGoogle Scholar
  10. 10.
    Meydani SN, et al. (1998) Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults. Am J Clin Nutr 68:311–318Google Scholar
  11. 11.
    Primary Prevention Project (2001) Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 357:89–95CrossRefGoogle Scholar
  12. 12.
    Sano M,et al. (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study. N Engl J Med 336:1216–1222CrossRefGoogle Scholar
  13. 13.
    SCF (Scientific Committee on Food) (2003) Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Vitamin EGoogle Scholar
  14. 14.
    Stephens NG, et al. (1996) Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347:781–786CrossRefPubMedGoogle Scholar
  15. 15.
    Yusef S, et al. (2000) Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes prevention Evaluation Study Investigators. N Engl J Med 342:154–160CrossRefPubMedGoogle Scholar

Copyright information

© Steinkopff Verlag 2005

Authors and Affiliations

  • Angelo Azzi
    • 1
  • Regina Brigelius-Flohé
    • 2
  • Frank Kelly
    • 3
  • John K. Lodge
    • 4
  • Nesrin Özer
    • 5
  • Lester Packer
    • 6
  • Helmut Sies
    • 7
  1. 1.Institute of Biochemistry and Molecular BiologyUniversity of BernBernSwitzerland
  2. 2.German Institute of Human NutritionBergholz-RehbrückeGermany
  3. 3.School of Health & Life SciencesKing’s College LondonLondonUK
  4. 4.School of Biomedical and Molecular SciencesUniversity of SurreyGuildford, Surrey,GU2 7XHUK
  5. 5.Marmara UniversityHaydarpasa-IstanbulTurkey
  6. 6.Dept. of Molecular Pharmacology and ToxicologyUniversity of Southern CaliforniaLos Angeles (CA)USA
  7. 7.Institut für Biochemie und MolekularbiologieHeinrich-Heine-UniversitätDüsseldorfGermany

Personalised recommendations