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European Journal of Nutrition

, Volume 44, Issue 2, pp 128–132 | Cite as

Effects of a tryptic hydrolysate from bovine milk αS1–casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations

  • M. Messaoudi
  • C. Lefranc–Millot
  • D. Desor
  • B. Demagny
  • L. Bourdon
ORIGINAL CONTRIBUTION

Summary

Background

Preclinical results in rats have demonstrated anxiolytic–like effects of a tryptic bovine αS1–casein hydrolysate.

Aim of the study

We investigated the putative effects of this tryptic hydrolysate on systolic (SBP), diastolic (DBP) blood pressures, heart rate (HR) values and plasma cortisol concentrations (CC) in human healthy volunteers facing successive stress situations.

Methods

The subjects were (double blind) randomly allocated to ingest three times, 12 hours apart, two capsules containing either 200 mg of αS1–casein hydrolysate (TS) or bovine skimmed milk powder as a placebo (CS). On the morning of the test day, a first blood sample for baseline measurement of CC was taken before the subjects were submitted to the Stroop test (ST) and, after a 30–min rest, to a Cold Pressor test (CPT). SBP, DBP, and HR were continuously recorded for 5 min before the ST and during each stress situation. A second blood sample was taken 15 min after the end of the CPT condition.

Results

ST and ST + CPT combined test situations increased SBP, DBP and HR. The significant “Treatment × SBP” and “Treatment × DBP” interactions indicated the lower percentage changes in SBP and DBP of the TS. In addition, the results showed a significant decrease of the CC in the TS but not in the CS throughout the ST + CPT combined stress tests. HR remained stable in TS between the initial rest period and the CPT unlike what happened in CS.

Conclusion

On the basis of blood pressure and cortisol changes, these results suggest an antistress profile of this αS1–casein hydrolysate in human subjects.

Key words

milk αS1–casein hydrolysate blood pressure heart rate cortisol stress 

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Copyright information

© Steinkopff Verlag 2004

Authors and Affiliations

  • M. Messaoudi
    • 1
  • C. Lefranc–Millot
    • 2
  • D. Desor
    • 3
  • B. Demagny
    • 2
  • L. Bourdon
    • 4
  1. 1.ETAP-Applied Ethology 13Vandoeuvre-lès-NancyFrance
  2. 2.INGREDIA ArrasFrance
  3. 3.Laboratoire de Neurosciences ComportementalesFaculté des Sciences Université Henri PoincaréVandoeuvre-lès-NancyFrance
  4. 4.Centre de Recherches du Service de Santé des ArméesLa TroncheFrance

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