European Journal of Nutrition

, Volume 43, Issue 6, pp 325–335 | Cite as

Beyond Deficiency:

Potential benefits of increased intakes of vitamin K for bone and vascular health
  • Cees Vermeer
  • Martin J. Shearer
  • Armin Zittermann
  • Caroline Bolton-Smith
  • Pawel Szulc
  • Stephen Hodges
  • Paul Walter
  • Walter Rambeck
  • Elisabeth Stöcklin
  • Peter Weber
REVIEW

Summary

Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. During recent years vitamin K-dependent proteins were discovered to be of vital importance for bone and vascular health. Recommendations for dietary vitamin K intake have been made on the basis of the hepatic requirements for the synthesis of blood coagulation factors. Accumulating evidence suggests that the requirements for other functions than blood coagulation may be higher. This paper is the result of a closed workshop (Paris, November 2002) in which a number of European vitamin K experts reviewed the available data and formulated their standpoint with respect to recommended dietary vitamin K intake and the use of vitamin K-containing supplements.

Key words

vitamin K gammacarboxy glutamate osteoporosis bone mineral density cardiovascular disease 

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Copyright information

© Steinkopff Verlag 2004

Authors and Affiliations

  • Cees Vermeer
    • 1
  • Martin J. Shearer
    • 2
  • Armin Zittermann
    • 3
  • Caroline Bolton-Smith
    • 4
  • Pawel Szulc
    • 5
  • Stephen Hodges
    • 6
  • Paul Walter
    • 7
  • Walter Rambeck
    • 8
  • Elisabeth Stöcklin
    • 9
  • Peter Weber
    • 9
  1. 1.Dept. of BiochemistryUniversity of MaastrichtMD MaastrichtThe Netherlands
  2. 2.St. Thomas’ HospitalLondonUK
  3. 3.University of BonnBonnGermany
  4. 4.MRC Human Nutrition ResearchCambridgeUK
  5. 5.INSERMLyonFrance
  6. 6.University College LondonLondonUK
  7. 7.University of BaselBaselSwitzerland
  8. 8.University of MunichMunichGermany
  9. 9.Roche Vitamins Ltd.BaselBasel

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