Advertisement

Zeitschrift für Rheumatologie

, Volume 78, Issue 3, pp 272–280 | Cite as

Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis

  • Y. H. LeeEmail author
  • G. G. Song
Originalien
  • 82 Downloads

Abstract

Objective

The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms are associated with susceptibility to ankylosing spondylitis (AS).

Methods

Meta-analyses were conducted to determine the associations between IL-23R polymorphisms and AS susceptibility in Europeans, Asians, and all subjects combined.

Results

A total of 17 studies (21 separate comparisons) were included in this meta-analysis. The meta-analysis revealed a significant association between AS and the two alleles of the rs11209032 polymorphism in all study subjects (odds ratio [OR] = 1.160, 95% confidence interval [CI] = 1.091–1.204, P < 0.001). Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.234, 95% CI = 1.159–1.313, P < 0.001), but not in Asians (OR = 1.003, 95% CI = 0.920–1.219, P = 0.942). Meta-analyses of the rs1004819, rs10489629, rs1343151, rs1495965, rs7517847, and rs11465804 polymorphisms showed the same pattern as shown for rs11209032. The meta-analysis also revealed a significant association between the two alleles of the rs2201841 and rs11209026 polymorphisms and the risk of developing AS in Europeans, but not in Asians. Interestingly, the rs10889677 polymorphism was not found to be associated with AS susceptibility in either Europeans or Asians.

Conclusions

This meta-analysis showed that several IL-23R polymorphisms are associated with the development of AS in Europeans.

Keywords

Interleukin-23 receptor Genetic polymorphism Ankylosing spondylitis Genetic association studies Meta-analysis 

Assoziationen zwischen Interleukin-23R-Polymorphismen und Empfänglichkeit für ankylosierende Spondylitis: eine aktualisierte Metaanalyse

Zusammenfassung

Ziel

Ziel der vorliegenden Studie war zu untersuchen, ob Interleukin-23R(IL-23R)-Polymorphismen mit der Empfänglichkeit für eine ankylosierende Spondylitis (AS) assoziiert sind.

Methoden

Es wurden Metaanalysen ausgeführt, um die Assoziationen zwischen IL-23R-Polymorphismen und AS-Empfänglichkeit bei Europäern, Asiaten und allen Teilnehmern zusammen zu ermitteln.

Ergebnisse

Insgesamt wurden 17 Studien (21 separate Vergleiche) in diese Metaanalyse eingeschlossen. Die Metaanalyse ergab eine signifikante Assoziation zwischen AS und den beiden Allelen des rs11209032-Polymorphismus bei allen Studienteilnehmern (Odds Ratio, OR = 1,160; 95 %-Konfidenzintervall, 95 %-KCI = 1,091–1,204; p < 0,001). Die Stratifizierung nach Ethnizität ergab eine signifikante Assoziation zwischen diesem Polymorphismus und AS bei Europäern (OR = 1,234; 95 %-KI = 1,159–1,313; p < 0,001), nicht aber bei Asiaten (OR = 1,003; 95 %-KI = 0,920–1,219; p = 0,942). Metaanalysen der Polymorphismen rs1004819, rs10489629, rs1343151, rs1495965, rs7517847 und rs11465804 wiesen das gleiche Muster auf, das für rs11209032 gezeigt wurde. Die Metaanalyse ergab auch eine signifikante Assoziation zwischen den beiden Allelen des rs2201841-und rs11209026-Polymorphismus und dem Risiko der Entstehung einer AS bei Europäern, nicht aber bei Asiaten. Interessant war, dass der rs10889677-Polymorphismus sich nicht als mit der Empfänglichkeit für AS assoziiert herausstellte, weder bei Europäern noch bei Asiaten.

Schlussfolgerung

Die vorliegende Metaanalyse zeigte, dass verschiedene IL-23R-Polymorphismen mit der Entstehung der AS bei Europäern assoziiert sind.

Schlüsselwörter

Interleukin-23-Rezeptor Genetischer Polymorphismus Ankylosierende Spondylitis Genetische Assoziationsstudien Metaanalyse 

Notes

Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical guidelines

Conflict of interest

Y. H. Lee and G. G. Song declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Brown MA, Wordsworth BP, Reveille JD (2002) Genetics of ankylosing spondylitis. Clin Exp Rheumatol 20:S43–49PubMedGoogle Scholar
  2. 2.
    Lee YH, Rho YH, Choi SJ, Ji JD, Song GG (2005) Ankylosing spondylitis susceptibility loci defined by genome-search meta-analysis. J Hum Genet 50:453–459CrossRefGoogle Scholar
  3. 3.
    Brown M (2007) Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology 47:132–137CrossRefGoogle Scholar
  4. 4.
    Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198:1951–1957CrossRefGoogle Scholar
  5. 5.
    Steinman L (2007) A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13:139–145CrossRefGoogle Scholar
  6. 6.
    Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461–1463CrossRefGoogle Scholar
  7. 7.
    Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80:273–290CrossRefGoogle Scholar
  8. 8.
    Ruan WF, Xie JT, Jin Q, Wang WD, Ping AS (2018) The diagnostic and prognostic role of interleukin 12B and Interleukin 6R gene polymorphism in patients with ankylosing spondylitis. J Clin Rheumatol 24:18–24PubMedGoogle Scholar
  9. 9.
    Su SS, Wang SL, Lu LJ, Lin L (2016) Association of interleukin-23 receptor gene single nucleotide polymorphisms with ankylosing spondylitis. Ann Clin Lab Sci 46:470–473PubMedGoogle Scholar
  10. 10.
    Daryabor G, Mahmoudi M, Jamshidi A, Nourijelyani K, Amirzargar A, Ahmadzadeh N, Farhadi E, Nicknam MH (2014) Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis. Eur Cytokine Netw 25:24–29PubMedGoogle Scholar
  11. 11.
    Dong H, Li Q, Zhang Y, Tan W, Jiang Z (2013) IL23R gene confers susceptibility to ankylosing spondylitis concomitant with uveitis in a Han Chinese population. PLoS ONE 8:e67505CrossRefGoogle Scholar
  12. 12.
    Qian BP, Jiang J, Ji ML, Wang B, Yu Y, Qiu Y (2013) Lack of associations between two previously identified susceptible single nucleotide polymorphisms of interleukin-23 receptor gene and ankylosing spondylitis: a replication study in a Chinese Han population. BMC Musculoskelet Disord 14:190CrossRefGoogle Scholar
  13. 13.
    Chen C, Zhang X, Li J, Wang Y (2012) Associations of IL-23R polymorphisms with ankylosing spondylitis in East Asian population: a new case-control study and a meta-analysis. Int J Immunogenet 39:126–130CrossRefGoogle Scholar
  14. 14.
    Wong RH, Wei JC, Huang CH, Lee HS, Chiou SY, Lin SH, Cai YW, Hung PH, Wang MF, Yang SF (2012) Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis. J Rheumatol 39:135–140CrossRefGoogle Scholar
  15. 15.
    Wang X, Huang J, Lin Z, Liao Z, Li C, Wei Q, Jiang Y, Zhao L, Gu J (2010) Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients. Rheumatol Int 30:955–959CrossRefGoogle Scholar
  16. 16.
    Davidson SI, Wu X, Liu Y et al (2009) Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum 60:3263–3268CrossRefGoogle Scholar
  17. 17.
    Pimentel-Santos FM, Ligeiro D, Matos M et al (2009) Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population. Clin Exp Rheumatol 27:800–806PubMedGoogle Scholar
  18. 18.
    Safrany E, Pazar B, Csongei V, Jaromi L, Polgar N, Sipeky C, Horvath IF, Zeher M, Poor G, Melegh B (2009) Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples. Scand J Immunol 70:68–74CrossRefGoogle Scholar
  19. 19.
    Sung IH, Kim TH, Bang SY, Kim TJ, Lee B, Peddle L, Rahman P, Greenwood CM, Hu P, Inman RD (2009) IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. J Rheumatol 36:1003–1005CrossRefGoogle Scholar
  20. 20.
    Karaderi T, Harvey D, Farrar C, Appleton LH, Stone MA, Sturrock RD, Brown MA, Wordsworth P, Pointon JJ (2009) Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series. Rheumatology (Oxford) 48:386–389CrossRefGoogle Scholar
  21. 21.
    Rueda B, Orozco G, Raya E, Fernandez-Sueiro JL, Mulero J, Blanco FJ, Vilches C, Gonzalez-Gay MA, Martin J (2008) The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Ann Rheum Dis 67:1451–1454CrossRefGoogle Scholar
  22. 22.
    Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39:1329CrossRefGoogle Scholar
  23. 23.
    Rahman P, Inman RD, Gladman DD, Reeve JP, Peddle L, Maksymowych WP (2008) Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheumatol 58:1020–1025CrossRefGoogle Scholar
  24. 24.
    Reveille JD, Sims A‑M, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Appleton LH (2010) Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 42:123CrossRefGoogle Scholar
  25. 25.
    Lee YH, Choi SJ, Ji JD, Song GG (2012) Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis. Inflamm Res 61:143–149CrossRefGoogle Scholar
  26. 26.
    Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Plos Med 6:e1000097CrossRefGoogle Scholar
  27. 27.
    Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558CrossRefGoogle Scholar
  28. 28.
    Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315:1533–1537CrossRefGoogle Scholar
  29. 29.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRefGoogle Scholar
  30. 30.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefGoogle Scholar
  31. 31.
    Linden SVD, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheumatol 27:361–368CrossRefGoogle Scholar
  32. 32.
    McKenzie BS, Kastelein RA, Cua DJ (2006) Understanding the IL-23–IL-17 immune pathway. Trends Immunol 27:17–23CrossRefGoogle Scholar
  33. 33.
    Zhang X‑Y, Zhang H‑J, Zhang Y, Fu Y‑J, He J, Zhu L‑P, Wang S‑H, Liu L (2006) Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics 57:934–943CrossRefGoogle Scholar
  34. 34.
    Kivitz A, Blanco R, Maradiaga M, Sieper J, Tahir H, Andersson M, Readie A, Porter B (2016) Secukinumab provides sustained improvement in physical, function, health-related quality of life, fatigue, and work productivity in patients with active psoriatic arthritis: 52-week results from an international phase 3 trial. J Clin Rheumatol 22:142–143Google Scholar
  35. 35.
    Baeten D, Sieper J, Braun J et al (2015) Secukinumab, an interleukin-17A Inhibitor, in ankylosing spondylitis. N Engl J Med 373:2534–2548CrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Rheumatology, Korea University Medical CenterKorea University College of MedicineSeoulKorea (Republic of)

Personalised recommendations