Zeitschrift für Rheumatologie

, Volume 78, Issue 3, pp 272–280 | Cite as

Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis

  • Y. H. LeeEmail author
  • G. G. Song



The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms are associated with susceptibility to ankylosing spondylitis (AS).


Meta-analyses were conducted to determine the associations between IL-23R polymorphisms and AS susceptibility in Europeans, Asians, and all subjects combined.


A total of 17 studies (21 separate comparisons) were included in this meta-analysis. The meta-analysis revealed a significant association between AS and the two alleles of the rs11209032 polymorphism in all study subjects (odds ratio [OR] = 1.160, 95% confidence interval [CI] = 1.091–1.204, P < 0.001). Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.234, 95% CI = 1.159–1.313, P < 0.001), but not in Asians (OR = 1.003, 95% CI = 0.920–1.219, P = 0.942). Meta-analyses of the rs1004819, rs10489629, rs1343151, rs1495965, rs7517847, and rs11465804 polymorphisms showed the same pattern as shown for rs11209032. The meta-analysis also revealed a significant association between the two alleles of the rs2201841 and rs11209026 polymorphisms and the risk of developing AS in Europeans, but not in Asians. Interestingly, the rs10889677 polymorphism was not found to be associated with AS susceptibility in either Europeans or Asians.


This meta-analysis showed that several IL-23R polymorphisms are associated with the development of AS in Europeans.


Interleukin-23 receptor Genetic polymorphism Ankylosing spondylitis Genetic association studies Meta-analysis 

Assoziationen zwischen Interleukin-23R-Polymorphismen und Empfänglichkeit für ankylosierende Spondylitis: eine aktualisierte Metaanalyse



Ziel der vorliegenden Studie war zu untersuchen, ob Interleukin-23R(IL-23R)-Polymorphismen mit der Empfänglichkeit für eine ankylosierende Spondylitis (AS) assoziiert sind.


Es wurden Metaanalysen ausgeführt, um die Assoziationen zwischen IL-23R-Polymorphismen und AS-Empfänglichkeit bei Europäern, Asiaten und allen Teilnehmern zusammen zu ermitteln.


Insgesamt wurden 17 Studien (21 separate Vergleiche) in diese Metaanalyse eingeschlossen. Die Metaanalyse ergab eine signifikante Assoziation zwischen AS und den beiden Allelen des rs11209032-Polymorphismus bei allen Studienteilnehmern (Odds Ratio, OR = 1,160; 95 %-Konfidenzintervall, 95 %-KCI = 1,091–1,204; p < 0,001). Die Stratifizierung nach Ethnizität ergab eine signifikante Assoziation zwischen diesem Polymorphismus und AS bei Europäern (OR = 1,234; 95 %-KI = 1,159–1,313; p < 0,001), nicht aber bei Asiaten (OR = 1,003; 95 %-KI = 0,920–1,219; p = 0,942). Metaanalysen der Polymorphismen rs1004819, rs10489629, rs1343151, rs1495965, rs7517847 und rs11465804 wiesen das gleiche Muster auf, das für rs11209032 gezeigt wurde. Die Metaanalyse ergab auch eine signifikante Assoziation zwischen den beiden Allelen des rs2201841-und rs11209026-Polymorphismus und dem Risiko der Entstehung einer AS bei Europäern, nicht aber bei Asiaten. Interessant war, dass der rs10889677-Polymorphismus sich nicht als mit der Empfänglichkeit für AS assoziiert herausstellte, weder bei Europäern noch bei Asiaten.


Die vorliegende Metaanalyse zeigte, dass verschiedene IL-23R-Polymorphismen mit der Entstehung der AS bei Europäern assoziiert sind.


Interleukin-23-Rezeptor Genetischer Polymorphismus Ankylosierende Spondylitis Genetische Assoziationsstudien Metaanalyse 



This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical guidelines

Conflict of interest

Y. H. Lee and G. G. Song declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Rheumatology, Korea University Medical CenterKorea University College of MedicineSeoulKorea (Republic of)

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