Zeitschrift für Rheumatologie

, Volume 75, Issue 6, pp 534–536 | Cite as

Fibroblastäre Modulatoren der Knochendestruktion

Leitthema: Meilensteine in der Rheumatologie: 75 Bände Innovation
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Fibroblastic modulators of bone destruction

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

B. Dankbar und T. Pap geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Literatur

  1. 1.
    Goldring SR (2002) Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol 14:406–410CrossRefPubMedGoogle Scholar
  2. 2.
    Redlich K, Hayer S, Ricci R et al (2002) Osteoclasts are essential for TNF- alpha-mediated joint destruction. J Clin Invest 110:1419–1427CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Schett G (2007) Cells of the synovium in rheumatoid arthritis. Osteoclasts. Arthritis Res Ther 9:203–208CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Goldring SR (2003) Inflammatory mediators as essential elements in bone remodeling. Calcif Tissue Int 73:97–100CrossRefPubMedGoogle Scholar
  5. 5.
    Polzer K, Zwerina J, Schett G et al (2008) Inflammation and destruction of the joints – the Wnt pathway. Joint Bone Spine 75:105–107CrossRefPubMedGoogle Scholar
  6. 6.
    Walsh NC, Crotti TN, Goldring SR et al (2005) Rheumatic diseases: the effects of inflammation on bone. Immunol Rev 208:228–251CrossRefPubMedGoogle Scholar
  7. 7.
    Lam J, Takeshita S, Barker JE et al (2000) TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 106:1481–1488CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Kotake S, Udagawa N, Takahashi N et al (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345–1352CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Lee SK, Gardner AE, Kalinowski JF et al (2006) RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production. Bone 38:678–685CrossRefPubMedGoogle Scholar
  10. 10.
    Kostenuik PJ (2005) Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 5:618–625CrossRefPubMedGoogle Scholar
  11. 11.
    Gravallese EM, Galson DL, Goldring SR et al (2001) The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption. Arthritis Res 3:6–12CrossRefPubMedGoogle Scholar
  12. 12.
    Pap T, Muller-Ladner U, Gay RE et al (2000) Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2:361–367CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Neumann E, Lefèvre S, Zimmermann B et al (2010) Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends Mol Med 16(458):468Google Scholar
  14. 14.
    Bartok B, Firestein GS (2010) Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 233:233–255CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Huber LC, Distler O, Tarner I et al (2006) Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford) 45:669–675CrossRefGoogle Scholar
  16. 16.
    Muller-Ladner U, Gay S (2002) MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction? Ann Rheum Dis 61:957–959CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Takayanagi H, Iizuka H, Juji T et al (2000) Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum 43:259–269CrossRefPubMedGoogle Scholar
  18. 18.
    Dankbar B, Fennen M, Brunert D et al (2015) Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med 21:1085–1090CrossRefPubMedGoogle Scholar
  19. 19.
    Wehmeyer C, Frank S, Beckmann D et al (2016) Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Sci Transl Med 8:330ra34CrossRefGoogle Scholar
  20. 20.
    McPherron AC, Lawler AM, Lee SJ (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387:83–90CrossRefPubMedGoogle Scholar
  21. 21.
    Bradley L, Yaworsky PJ, Walsh FS (2008) Myostatin as a therapeutic target for musculoskeletal disease. Cell Mol Life Sci 65:2119–2124CrossRefPubMedGoogle Scholar
  22. 22.
    Hamrick MW (2003) Increased bone mineral density in the femora of GDF8 knockout mice. Anat Rec 272:388–391CrossRefGoogle Scholar
  23. 23.
    Hamrick MW, Pennington C, Byron CD (2003) Bone architecture and disc degeneration in the lumbar spine of mice lacking GDF-8 (myostatin). J Orthop Res 21:1025–1032CrossRefPubMedGoogle Scholar
  24. 24.
    Bialek P, Parkington J, Warner L et al (2008) Mice treated with a myostatin/GDF-8 decoy receptor, ActRIIB-Fc, exhibit a tremendous increase in bone mass. Bone 42:S46CrossRefGoogle Scholar
  25. 25.
    Kellum E, Starr H, Arounleut P et al (2009) Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume. Bone 44:17–23CrossRefPubMedGoogle Scholar
  26. 26.
    Keffer J, Probert L, Cazlaris H et al (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025–4031PubMedPubMedCentralGoogle Scholar
  27. 27.
    Okamoto M, Murai J, Yoshikawa H et al (2006) Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J Bone Miner Res 21:1022–1033CrossRefPubMedGoogle Scholar
  28. 28.
    Krishnan V, Bryant HU, Macdougald OA (2006) Regulation of bone mass by Wnt signaling. J Clin Invest 116:1202–1209CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Glass DA, Karsenty G (2006) Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway. Curr Top Dev Biol 73:43–84CrossRefPubMedGoogle Scholar
  30. 30.
    Wodarz A, Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59–88CrossRefPubMedGoogle Scholar
  31. 31.
    Bodine PV, Komm BS (2006) Wnt signaling and osteoblastogenesis. Rev Endocr Metab Disord 7:33–39CrossRefPubMedGoogle Scholar
  32. 32.
    Johnson ML, Harnish K, Nusse R et al (2004) LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res 19:1749–1757CrossRefPubMedGoogle Scholar
  33. 33.
    Li J, Sarosi I, Cattley RC et al (2006) Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39:754–766CrossRefPubMedGoogle Scholar
  34. 34.
    Mao B, Wu W, Li Y et al (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411:321–325CrossRefPubMedGoogle Scholar
  35. 35.
    Li X, Zhang Y, Kang H et al (2005) Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 280:19883–19887CrossRefPubMedGoogle Scholar
  36. 36.
    Semenov M, Tamai K, He X (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 280:26770–26775CrossRefPubMedGoogle Scholar
  37. 37.
    Poole KE, van Bezooijen RL, Loveridge N et al (2005) Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 19:1842–1844PubMedGoogle Scholar
  38. 38.
    Diarra D, Stolina M, Polzer K et al (2007) Dickkopf-1 is a master regulator of joint remodeling. Nat Med 13:156–163CrossRefPubMedGoogle Scholar
  39. 39.
    Recker RR, Benson CT, Matsumoto T et al (2015) A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res 30:216–224CrossRefPubMedGoogle Scholar
  40. 40.
    McClung MR, Grauer A, Boonen S et al (2014) Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med 370:412–420CrossRefPubMedGoogle Scholar
  41. 41.
    Bertolini DR, Nedwin GE, Bringman TS et al (1986) Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319:516–518Google Scholar
  42. 42.
    Lange U, Teichmann J, Muller-Ladner U et al (2005) Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective open-label pilot study. Rheumatology (Oxford) 44:1546–1548Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institut für Experimentelle Muskuloskelettale MedizinUniversitätsklinikum MünsterMünsterDeutschland

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