Zeitschrift für Rheumatologie

, Volume 73, Issue 4, pp 360–362 | Cite as

B-Lymphozyten als Effektoren und Regulatoren beim systemischen Lupus erythematosus

Neues aus der Forschung
  • 235 Downloads

B-lymphocytes as effectors and regulators in systemic lupus erythematosus

Notes

Interessenkonflikt

T.H. Winkler gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Arbuckle MR, Mcclain MT, Rubertone MV et al (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349:1526–1533PubMedCrossRefGoogle Scholar
  2. 2.
    Barr TA, Shen P, Brown S et al (2012) B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. J Exp Med 209:1001–1010PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Blair PA, Noreña LY, Flores-Borja F et al (2010) CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 32:129–140PubMedCrossRefGoogle Scholar
  4. 4.
    Kalampokis I, Yoshizaki A, Tedder TF (2013) IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther 15(Suppl 1):1–12CrossRefGoogle Scholar
  5. 5.
    Mumtaz IM, Hoyer BF, Panne D et al (2012) Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity. J Autoimmun 39:180–188PubMedCrossRefGoogle Scholar
  6. 6.
    Neubert K, Meister S, Moser K et al (2008) The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14:748–755PubMedCrossRefGoogle Scholar
  7. 7.
    Neves P, Lampropoulou V, Calderon-Gomez E et al (2010) Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 33:777–790PubMedCrossRefGoogle Scholar
  8. 8.
    Pawar RD, Ramanjaneyulu A, Kulkarni OP et al (2007) Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 18:1721–1731PubMedCrossRefGoogle Scholar
  9. 9.
    Teichmann LL, Schenten D, Medzhitov R et al (2013) Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 38:528–540PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    Wahren-Herlenius M, Dorner T (2013) Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 382:819–831PubMedCrossRefGoogle Scholar
  11. 11.
    Yoshizaki A, Miyagaki T, Dilillo DJ et al (2012) Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491:264–268PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Nikolaus-Fiebiger-Zentrum für Molekulare Medizin, Lehrstuhl GenetikFriedrich-Alexander Universität Erlangen-NürnbergErlangenDeutschland

Personalised recommendations