Zeitschrift für Rheumatologie

, 68:712

Interleukin-1-Zytokine, Inflammasome, NOD-Signalosome und Autoinflammation



Die Erforschung der Grundlagen hereditärer autoinflammatorischer Syndrome hat große Bedeutung erlangt für das Verständnis und die Therapie von erworbenen IL-1β-assoziierten nichtinfektiösen Entzündungskrankheiten. Im Fokus des Interesses befinden sich makromolekulare zytosolische Komplexe zur Synthese und Aktivierung von Zytokinen der IL-1-Familie: NOD-Signalosome und Inflammasome.


Interleukin-1-Zytokine Inflammasome NOD-Signalosome  Autoinflammation Hereditäre autoinflammatorische Syndrome 



„Apoptosis-associated speck-like protein“




„Baculovirus inhibitor of apoptosis protein repeat“


„Major histocompatibility complex (MHC) class II transactivator“


Cryopyrin-assoziiertes periodisches Fiebersyndrom


Caspasen-rekrutierende Domäne


„Chronic infantile neurologic cutaneous and articular syndrome“


„Familial cold autoinflammatory syndrome“


Familiäres Mittelmeerfieber




„ICE-protease activating factor“






Nukleotid-bindende Oligomerisierungsdomäne


„NOD-like receptor“


Domäne, welche von NAIP, CIITA, HET-E, TP-1 verwendet wird


Neuronales Apoptose-inhibitorisches Protein


NACHT-LRR-PYD-enthaltendes Protein


„Neonatal-onset multisystem inflammatory disease“


„Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome“


„Pattern-recognition receptor“ (Mustererkennungsrezeptor)


„Pry (PTPN13-related protein, Y-linked) and SpIA ryanodine receptor (RyR)-like“


Prolin-Serin-Threonin-Phosphatasen-interagierendes Protein 1




Rezeptor-interagierendes Protein 2


Synovitis, Akne, Pustulose, Hyperostose und Osteitis (Syndrom)


„Signal transduction 2 protein“



Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation


The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes.


Interleukin-1 cytokines Inflammasomes NOD-signalosomes Autoinflammation Hereditary autoinflammatory syndromes 


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Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  1. 1.Division of Infection, Inflammation & ImmunitySouthampton General Hospital, School of Medicine, University of Southampton, UKSouthamptonGroßbritannien

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