Zelluläre Therapie von Autoimmunerkrankungen
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Zusammenfassung
Neben den natürlichen regulatorischen T-Zellen (Tregs) aus dem Thymus sind eine Vielzahl peripher induzierter Tregs von zentraler Bedeutung für die Immunhomöostase. Durch homotypische Wechselwirkungen zwischen aktivierten Effektor-T-Zellen und ruhenden Gedächtnis-T-Zellen konnten in vitro Tregs induziert werden, die sowohl Interleukin-10 als auch Interferon-γ produzieren. Dieser Mechanismus in der Treg-Entstehung erlaubt neue Einblicke in die Grundlagen der T-Zell-Vakzinierung, die bereits erfolgversprechend in Pilotstudien bei Patienten mit multipler Sklerose und rheumatoider Arthritis eingesetzt wurde.
Schlüsselwörter
Homotypische T-Zell-Wechselwirkungen Regulatorische T-Zellen T-Zell-Vakzinierung Autoimmunerkrankungen Zelluläre ImmuntherapieCellular therapy in autoimmune disease
Abstract
In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNγ producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.
Keywords
Cell-to-cell interaction Regulatory T-cell Vaccination Autoimmune disease Adoptive cellular immunotherapyNotes
Interessenkonflikt
Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht.
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