Skip to main content

Advertisement

SpringerLink
Log in

Myopathie beim Behçet-Syndrom

Medikamentennebenwirkung oder Ausdruck der Grunderkrankung?

Myalgia in Neuro-Behçet’s disease

Medication side effects or expression of underlying disease

  • Kasuistiken
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Wir schildern den 9-jährigen Krankheitsverlauf einer türkischstämmigen Patientin mit chronisch-parenchymatösem Neuro-Behçet, bei der im Verlauf Myalgien und erhöhte Muskelenzyme auftraten. Bei elektromyographisch und bioptisch festgestellter Myopathie erfolgte differenzialdiagnostisch die Abgrenzung zu Medikamentennebenwirkungen.

Nach Erhöhung einer kombinierten Immunsuppression war keine Erkrankungsaktivität sowohl der Myopathie als auch des Behçet-Syndroms mehr nachweisbar.

Abstract

In this report we present the 9-year course of disease in a woman of Turkish origin suffering from Behçet’s disease with parenchymal CNS involvement combined with myalgia. Differential diagnoses, such as drug-induced neuromyopathy were excluded on the basis of electromyographic and bioptic tests.

We were able to arrest progression of symptoms of both the myopathy and the Neuro-Behçet’s disease by means of increased combined immunosuppressive therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Akman-Demir G, Seradaroglu P, Tasci B (1999) Clinical pattern of neurological involvement in Behçet’s disease. Brain 122: 2171–2181

    Article  PubMed  Google Scholar 

  2. Ben Ghorbel I, Ibnelhadj Z, Zouari M et al. (2005) Behçet’s disease associated with peripheral neuropathy. Rev Neurol 161: 218–220

    Article  Google Scholar 

  3. Berlit P (2005) Zerebrale Vaskulitis – Behçet-Syndrom In: Diener HC et al. (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. Thieme, Stuttgart

  4. Berlit P (Hrsg) (2007) Klinische Neurologie. Springer, Berlin Heidelberg New York

  5. Birol A, Ulkatan S, Kocak M, Erkek E (2004) Peripheral neuropathy in Behçet’s disease. J Dermatol 31: 455–459

    PubMed  Google Scholar 

  6. Budak F, Efendi H, Apaydin R et al. (2000) The F response parameters in Behçet’s disease. Electromyogr Clin Neurophysiol 40: 45–48

    PubMed  CAS  Google Scholar 

  7. Coban O, Bahar S, Akman-Demir G et al. (1999) Masked assessment of MRI findings: is it possible to differentiate neuro-Behçet’s disease from other central nervous system? Neuroradiology 41: 255–260

    Article  PubMed  CAS  Google Scholar 

  8. Cockburn IT, Krupp P (1982) The risk of neoplasms in patients treated with CSA. J Autoimmun 2: 723–731

    Article  Google Scholar 

  9. Duran E, Chacon JR (2001) Behçet’s disease with atypical double neurological involvement. Rev Neurol 33: 333–334

    PubMed  CAS  Google Scholar 

  10. Fujii Y, Arimura Y, Takahashi N et al. (2003) A case of Behçet’s disease associated with neuromyopathy induced by combination therapy with colchicine and cyclosporine. Ryumachi 43: 44–50

    PubMed  Google Scholar 

  11. Gardner-Medwin JM, Smith NJ, Powell RJ (1994) Clinical experience with thalidomide in the management of severe oral and genital ulceration in conditions such as Behçet’s disease: use of neurophysiological studies to detect thalidomide neuropathy. Ann Rheum Dis 53: 828–832

    Article  PubMed  CAS  Google Scholar 

  12. Gonzales-Gay MA, Fernandez Camblor B, Sanchez Andrade A et al. (1991) Behçet syndrome and peripheral neuropathy as a possible new minor criterion. Rev Clin Esp 189: 154–155

    Google Scholar 

  13. Hatemi G, Bang D, Bodaghi B et al. Eular Recommendations for the management of Behçet’s disease. Speakers presentation. Ann Rheum Dis (Suppl 2) 66: 44

  14. International Study Group for Behçet’s disease (1990) Criteria for Behçet’s disease. Lancet 335: 1078–1080

    Google Scholar 

  15. Kotter I, Aepinus C, Graepler F et al. (2001) HHV8 associated Kaposi’s sarcoma during triple immunosuppressive treatment with cyclosporin A, azathioprine, and prednisolone for ocular Behcet’s disease and complete remission of both disorders with interferon alpha. Ann Rheum Dis 60: 83–86

    Article  PubMed  CAS  Google Scholar 

  16. Kotter I, Gunaydin I, Batra M et al. (2006) CNS involvement occurs more frequently in patients with Behcet’s disease under cyclosporin A (CSA) than under other medications – results of a retrospective analysis of 117 cases. Clin Rheumatol 25: 482–486

    Article  PubMed  Google Scholar 

  17. Lingenfelser T, Duerk H, Stevens A et al. (1992) Generalized myositis in Behçet’s diasease: treatment with cyclosporine. Ann Intern Med 116: 651–653

    PubMed  CAS  Google Scholar 

  18. Sarui H, Maruyama T, Ito I et al. (2002) Necrotising myositis in Behçet’s disease: characteristic features on magnetic resonance imaging and a review of the literature. Ann Rheum Dis 61: 751–752

    Article  PubMed  CAS  Google Scholar 

  19. Uziel Y, Lazarov A, Cordoba M, Wolach B (2000) Pediatric Behçet disease manifesting as recurrent myositis: from an incomplete to a full-blown form. Eur J Pediatr 159: 507–508

    Article  PubMed  CAS  Google Scholar 

  20. Worthmann F, Bruns J, Turker T, Gosztonyi G (1996) Muscular involvement in Behçet’s disease: case report and review of the literature. Neuromuscul Disord 6: 247–253

    Article  PubMed  CAS  Google Scholar 

  21. Yazici H, Tuzuner N, Tuzun Y, Yurdakul S (1981) Localized myositis in Behçet’s diasease. Arthritis Rheum 24: 636

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenskonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Klinik für Neurologie mit klinischer Neurophysiologie, Alfried Krupp von Bohlen und Halbach Krankenhaus, Alfried-Krupp-Straße 21, 45117, Essen, Deutschland

    M. Krämer & P. Berlit

  2. Klinik für Innere Medizin II und Nephrologie, Alfried Krupp von Bohlen und Halbach Krankenhaus, Essen, Deutschland

    M.W. Baumgärtel

  3. Institut für Neuropatholgie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    E. Neuen-Jacob

Authors
  1. M. Krämer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M.W. Baumgärtel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Neuen-Jacob
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Berlit
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Krämer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krämer, M., Baumgärtel, M., Neuen-Jacob, E. et al. Myopathie beim Behçet-Syndrom. Z. Rheumatol. 67, 232–236 (2008). https://doi.org/10.1007/s00393-008-0285-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-008-0285-6

Schlüsselwörter

Keywords

Search

Navigation