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Zeitschrift für Rheumatologie

, Volume 66, Issue 3, pp 212–218 | Cite as

Autoantikörperprofile bei der rheumatoiden Arthritis

  • E. Feist
  • K. Egerer
  • G.-R. Burmester
Leitthema

Zusammenfassung

In der Labordiagnostik der rheumatoiden Arthritis (RA) hat der Nachweis von Antikörpern gegen citrullinierte Antigene (ACPA) inzwischen einen festen Stellenwert eingenommen. Durch ihre hohe diagnostische Spezifität ergänzen sie wesentlich den traditionellen Rheumafaktor und spielen darüber hinaus in der Früherkennung der RA eine wichtige Rolle. Für beide Marker ist eine Assoziation mit einem schweren Krankheitsverlauf der RA belegt, wobei jedoch nur der Nachweis des Rheumafaktors international standardisiert erfolgt. Ob Autoantikörperprofile auch zur Stratifizierung und zum Monitoring der RA angewandt werden können, wird gegenwärtig von zahlreichen Arbeitsgruppen untersucht.

Schlüsselwörter

Autoimmunerkrankung Rheumatoide Arthritis Rheumafaktor Citrullinierte Antigene 

Autoantibody profile in rheumatoid arthritis

Abstract

Antibodies against citrullinated protein/peptides antigens (ACPA) are well recognized serological markers for rheumatoid arthritis. In addition to rheumatoid factor, they provide high diagnostic specificity and are also useful diagnostic tools in the search for early disease manifestation. As shown by several studies, both autoantibodies correlate with disease severity and the radiologic progression of rheumatoid arthritis. However, it is important to note that only the detection of rheumatoid factors is internationally standardized. Whether autoantibody profiling is also of significance for the stratification and monitoring of rheumatoid arthritis is the focus of ongoing investigations.

Keywords

Autoimmune disease Rheumatoid arthritis Rheumatoid factor Citrullinated protein 

Notes

Interessenkonflikt

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

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Copyright information

© Springer Medizin Verlag 2007

Authors and Affiliations

  1. 1.Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische ImmunologieCharité - Universitätsmedizin BerlinBerlinDeutschland

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