Zeitschrift für Rheumatologie

, Volume 65, Issue 7, pp 576–586 | Cite as

Systemischer Lupus erythematodes im Kindes- und Jugendalter

  • Dr. S. Sallmann
  • B. Fiebig
  • C. M. Hedrich
  • G. Heubner
  • M. Gahr
Leitthema

Zusammenfassung

Der Anteil an SLE-Patienten im Kindes- und Jugendalter macht 15–20% aller SLE-Patienten aus. Die klinische Symptomatik unterscheidet sich nicht wesentlich von der erwachsener Patienten. Jedoch scheint die Erkrankung in jungen Jahren zumindest initial schwerer zu verlaufen und mit einer höheren Organbeteiligung einherzugehen. Eine rasche Diagnose und anschließende Behandlung sind nötig, um eine relevante Organschädigung zu verhindern. Die Überlebensrate hat sich in den letzten Jahrzehnten, nach Einführung der Glukokortikoide und Immunsuppressiva, deutlich gebessert, sodass das Augenmerk nun auf die Verminderung von Langzeitkomplikationen und Therapienebenwirkungen gelegt werden muss. Einheitliche Therapiestrategien gibt es nicht, jedoch vielversprechende neue Therapieansätze. Diese Übersichtsarbeit gibt Einblicke in die Epidemiologie, Pathogenese, Klinik und Therapie des juvenilen SLE.

Schlüsselwörter

Systemischer Lupus erythematodes (SLE) Kindes- und Jugendalter Pathogenese Klinische Symptomatik 

Systemic lupus erythematosus in children and adolescents

Abstract

Children and adolescents represent 15–20% of all systemic lupus erythematosus (SLE) patients. Although the clinical presentation and immunological findings are similar to those of adult SLE, children usually have a more severe disease at onset with higher rates of organ involvement. Rapid diagnosis and subsequent therapy are necessary to prevent major organ damage. The survival of children with SLE has improved dramatically over the past decades due to the introduction of steroids and immunosuppressive drugs. New strategies to improve the long-term course of the disease and to reduce potential drug toxicities are necessary. A common concept does not exist. There are some promising new drugs. This review article summarizes the epidemiology, pathogenesis, clinical manifestations and therapy of childhood and adolescent-onset SLE.

Keywords

SLE Childhood and adolescence Pathogenesis Clinical manifestations 

Notes

Interessenkonflikt

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

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Copyright information

© Springer Medizin Verlag 2006

Authors and Affiliations

  • Dr. S. Sallmann
    • 2
  • B. Fiebig
    • 2
  • C. M. Hedrich
    • 2
  • G. Heubner
    • 1
  • M. Gahr
    • 2
  1. 1.Kinderklinik Freital, Weisseritztalkliniken GmbHDeutschland
  2. 2.Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Carl Gustav CarusDresdenDeutschland

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