Zeitschrift für Rheumatologie

, Volume 61, Issue 6, pp 703–709

Prolactin and thyroid hormones in patients with systemic sclerosis: correlations with disease manifestations and activity

  • Amira A. Shahin
  • Saleh Abdoh
  • Mohamad Abdelrazik
ORIGINAL CONTRIBUTION

DOI: 10.1007/s00393-002-0413-7

Cite this article as:
Shahin, A., Abdoh, S. & Abdelrazik, M. Z Rheumatol (2002) 61: 703. doi:10.1007/s00393-002-0413-7

Summary.

Objective: To determine serum levels of prolactin (PRL) and thyroid hormones and to investigate the correlation between these hormones and different disease manifestations in patients with systemic sclerosis (SSc). Methods: Twenty four patients with SSc (23 women, mean age 37.7±12.7) were subjected to thyroid hormones assessment. Prolactin (PRL) was assessed in 23female patients. The patients were evaluated regarding different disease manifestations. Fifteen normal female volunteers were involved as controls. Results: Serum levels of PRL in all patients was significantly higher than controls (16.75±9.06 for patients vs. 11.6±4.5 for controls with p<0.001). Eight patients out of 23 (34.8%) showed hyperprolactinemia. In patients with diffuse SSc (dSSc), PRL levels showed significant correlation with the rate of skin tethering (r=+0.72, p<0.01) and abnormal left ventricular filling pattern (↓E/A ratio), i.e., occurrence of diastolic dysfunction (r=+0.65, p<0.05). Hyperprolactinemia in all patients correlated significantly with disease duration (r=–0.42, p<0.05).     Mean serum levels of free thyroxin (FT4) in all patients were significantly lower than the control group(7.46±2.7 for patients vs 10.47±2.5 with p<0.001). Eight out of all 24 patients (33.3%) showed hypothyroidism. In groupA (duration<3years); FT4 levels correlated significantly with Dlco% (r=+0.90, p<0.01). While in groupB (duration>3years), T4 hypothyroidism correlated significantly with hand joint restriction of motion (r=+0.66, p<0.01).    Serum levels of triiodothironine (FT3) in all patients were nonsignificantly lower than the control group (4.8±2.3 for patients vs 5.3±1.9 for controls, P=NS). Three patients out of 24 (12.5%) showed T3 thyrotoxicosis. Serum levels of T3 correlated significantly with liver enzyme elevations (r=+0.46, p<0.05) and ESR (r=+0.41, p<0.05). Conclusion: This study demonstrates the close association between PRL or thyroid hormones and some organ involvement in SSc.

Key words Prolactin thyroid hormones systemic sclerosis liver enzymes diastolic dysfunction 

Prolaktin und Schilddrüsenhormone bei Patienten mit systemischer Sklerose: Zusammenhänge mit Krankheitsmanifestationen und Aktivität

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Amira A. Shahin
    • 1
  • Saleh Abdoh
    • 2
  • Mohamad Abdelrazik
    • 2
  1. 1.Departments of Rheumatoloy, Rehabilitation Faculty of Medicine Cairo University Cairo, Egypt. rughe@rusys.eg.netEG
  2. 2.Department of Nuclear Medicine Faculty of Medicine Cairo University Cairo, EgyptEG

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