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Zeitschrift für Kardiologie

, Volume 90, Supplement 3, pp 38–42 | Cite as

Transcriptional regulation of matrix gla protein

  • A. Farzaneh-Far
  • P.L. Weissberg
  • D. Proudfoot
  • C.M. Shanahan

Summary

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cels (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor β (TGFβ) whereas it is upregulated by vitamin D3 and cyclic AMP.

Key words Calcification – vascular smooth muscle cells – matrix gla protein (MGP) 

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Copyright information

© Steinkopff Verlag 2001

Authors and Affiliations

  • A. Farzaneh-Far
    • 1
  • P.L. Weissberg
    • 1
  • D. Proudfoot
    • 1
  • C.M. Shanahan
    • 1
  1. 1.Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital (ACCI level 6), Hills Road, Cambridge CB2 2QQ, UK, E-mail: aff24@cam.ac.ukGB

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