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Clinical Research in Cardiology

, Volume 109, Issue 1, pp 46–53 | Cite as

Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry

  • Maryna Masyuk
  • Peter Abel
  • Martin Hug
  • Bernhard Wernly
  • Assad Haneya
  • Stefan Sack
  • Konstantinos Sideris
  • Nicolas Langwieser
  • Tobias Graf
  • Georg Fuernau
  • Marcus Franz
  • Ralf Westenfeld
  • Malte Kelm
  • Stephan B. Felix
  • Christian JungEmail author
Original Paper

Abstract

Background

The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge® (Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.

Methods

A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.

Results

In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (p < 0.05 versus below 10 mmol/L).

Conclusion

The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.

Keywords

Cardiogenic shock Mechanical circulatory support Extracorporeal life support ECLS Cardiac arrest 

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Maryna Masyuk
    • 1
  • Peter Abel
    • 2
  • Martin Hug
    • 3
  • Bernhard Wernly
    • 4
  • Assad Haneya
    • 5
  • Stefan Sack
    • 6
  • Konstantinos Sideris
    • 7
  • Nicolas Langwieser
    • 8
  • Tobias Graf
    • 9
  • Georg Fuernau
    • 9
  • Marcus Franz
    • 10
  • Ralf Westenfeld
    • 1
  • Malte Kelm
    • 1
    • 11
  • Stephan B. Felix
    • 2
    • 12
  • Christian Jung
    • 1
    Email author
  1. 1.Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Department of MedicineUniversity Hospital DüsseldorfDüsseldorfGermany
  2. 2.Division of Cardiology, Pneumology and Critical Care Medicine, Department of Internal Medicine BUniversity Medicine GreifswaldGreifswaldGermany
  3. 3.Department of Cardiology, Pulmonology and Internal Intensive Care MedicineStädtisches Klinikum München GmbH, Klinikum NeuperlachMunichGermany
  4. 4.Department of CardiologyParacelsus Medical UniversitySalzburgAustria
  5. 5.Department of Cardiovascular SurgeryUniversity of SchleswigKielGermany
  6. 6.Department of Cardiology, Pneumology, and Internal Intensive Care Medicine, Schwabing HospitalAcademic Municipal Hospital MunichMunichGermany
  7. 7.Department of Cardiovascular Surgery, German Heart CenterTechnische Universität München (TUM)MunichGermany
  8. 8.Medical Clinic I, Klinikum rechts der IsarTechnical University of MunichMunichGermany
  9. 9.Department of Cardiology, Angiology, Intensive Care Medicine, Medical Clinic IIUniversity Heart Center LübeckLübeckGermany
  10. 10.Department of Cardiology, Clinic of Internal Medicine I, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  11. 11.CARID: Cardiovascular Research Institute DüsseldorfDüsseldorfGermany
  12. 12.DZHK (German Center for Cardiovascular Research), Partner Site GreifswaldGreifswaldGermany

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