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Clinical Research in Cardiology

, Volume 108, Issue 9, pp 1053–1058 | Cite as

Relation of lowering door-to-balloon time and mortality in ST segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

  • David ZahlerEmail author
  • Keren Lee-Rozenfeld
  • Dor Ravid
  • Zach Rozenbaum
  • Shmuel Banai
  • Gad Keren
  • Yacov Shacham
Original Paper

Abstract

Background

Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend a door-to-balloon time (DBT) of ≤ 90 min for patients undergoing primary percutaneous coronary intervention (PCI). We aimed to investigate the possible impact of further reduction in DBT intervals beyond the 90 min cutoff on short and long-term outcomes among STEMI patients undergoing primary PCI.

Methods

We retrospectively studied 889 STEMI patients (median age 61 years, 83% men) who underwent successful primary PCI and had a DBT of ≤ 90 min. Patients were stratified according to DBT into 2 groups: < 60 min and 60–90 min. Patients records were assessed for the occurrence of in-hospital complications, 30-day and 1-year mortality.

Results

Patients having DBT < 60 min (n = 608, 68%) were more likely to present earlier, in daytime and weekdays, and had better post-procedural left ventricular ejection fraction and lower 30-day mortality (3% vs. 6%, p = 0.03). Mortality over 1-year was significantly lower among patients having DBT < 60 compared to DBT of 60–90 min (4.6% vs. 9.6%, p = 0.004). In a binary logistic regression model DBT < 60 min was associated with 51% risk reduction for 1-year mortality (OR 0.49, 95% CI 0.25–0.93, p = 0.03).

Conclusions

Among STEMI patients undergoing primary PCI within 90 min of admission DBT < 60 min was independently associated with better 1-year mortality.

Keywords

ST-segment elevation myocardial infarction Door-to-balloon time Primary percutaneous coronary intervention Cardiac intensive care unit 

Notes

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

The study protocol was approved by the local institutional ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informal consent

All persons gave their informed consent prior to their inclusion in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Cardiovascular Diseases and Internal Medicine, Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

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