Percutaneous closure of a large atrial septal defect presenting with acute severe hemolysis

  • Manli Yu
  • Xinghua Shan
  • Yuan Bai
  • Yongwen Qin
  • Xianxian ZhaoEmail author
Letter to the Editors


Hemolysis induced by occlude devices to repair the structural cardiac defects is not very infrequent in intervention cardiology. The unavoidable residual leaks, which are featured by high velocity, vortices, and rapid deceleration, impose significant shear on red blood cells leading to hemolysis [1, 2]. There are several cases that reported acute hemolysis after transcatheter closure of VSD or PDA in the literature [3, 4]. However, hemolysis due to intracardiac device for ASD closure is rather rare. Although in some cases surgical removal of the device or transcatheter occlusion of a residual shunt may be necessary, most hemolysis can be conservatively managed with fluids, sodium bicarbonate, and corticosteroids.

A 51-year-old female weighing 54 kg was admitted to the catheter lab with the aim of performing a transcatheter device closure of ASD. She presented a 2-year history of exertional chest distress. The second heart sound was prominent, and a grade 3/6 systolic murmur was...



This study was supported by the National Natural Science Foundation of China (81400287). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.1Department of Cardiovasology, Changhai HospitalSecond Military Medical UniversityShanghaiChina

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