Clinical Research in Cardiology

, Volume 101, Issue 10, pp 837–845 | Cite as

Diagnostic and prognostic performance of a novel high-sensitivity cardiac troponin T assay compared to a contemporary sensitive cardiac troponin I assay in patients with acute coronary syndrome

  • M. Mueller
  • S. Celik
  • M. Biener
  • M. Vafaie
  • K. Schwoebel
  • K. C. Wollert
  • J. L. Januzzi
  • H. A. Katus
  • E. Giannitsis
Original Paper

Abstract

Objective

The study sought to compare the clinical performance of two more sensitive cardiac troponin (cTn) assays, a novel high-sensitivity (hs) troponin T assay and a contemporary cTnI assay.

Methods

We measured hs-cTnT (Roche TnThs) and cTnI (Siemens Centaur Ultra) on presentation in 1,384 patients with suspected acute coronary syndrome (ACS) who underwent early invasive strategy within 24 h after presentation. Kaplan–Meier, Cox proportional hazards, and receiver-operating characteristic (ROC) analysis was used to compare their prognostic performance for the prediction of all-cause death and death/MI (myocardial infarction) after a median of 271 days. We also compared the diagnostic performance of these assays on presentation for early diagnosis of non-STEMI.

Results

Both hs-cTnT and cTnI were independently predictive of long-term death (OR 3.51 vs. 2.19) and the composite of death/MI (OR 9.24 vs. 3.61), across the spectrum of ACS and in patients without ACS. When used as a continuous variable, ROC analysis demonstrated significantly higher areas under the curve (AUC) for hs-cTnT as compared to cTnI for the prediction of death/MI (0.721 vs. 0.672, P = 0.024), a trend to better prediction of all-cause death (0.721 vs. 0.672, P = 0.093) and significantly higher AUC for early diagnosis of non-STEMI (0.965 vs. 0.901, P < 0.001).

Conclusion

Using the 99th percentile cutoff for hs-cTnT and cTnI, both assays enable prediction of adverse long-term outcomes and earlier diagnosis of non-STEMI. Used as a continuous variable, the hs-cTnT assay showed superior performance compared to the cTnI assay, especially in regard to prognosis.

Keywords

High-sensitivity troponin Acute coronary syndrome Prognosis Early diagnosis 

Notes

Acknowledgments

The investigations were supported by Roche Diagnostics, Germany providing hs-TnT assays.

Conflict of interest

EG has received financial support for clinical trials from Roche Diagnostics, Germany. He is consultant to Roche Diagnostics and receives honoraria for lectures from Roche Diagnostics. JLJ has received grant support from Roche Diagnostics, and has received honoraria for lectures from Roche Diagnostics. HAK has developed the cTnT assay and holds a patent jointly with Roche Diagnostics. He has received grants and research support from several companies, and has received honoraria for lectures from Roche Diagnostics.

Supplementary material

392_2012_469_MOESM1_ESM.doc (23 kb)
Online Resource 1 (DOC 23 kb)
392_2012_469_MOESM2_ESM.ppt (151 kb)
Online Resource 2 (PPT 154 kb)
392_2012_469_MOESM3_ESM.ppt (70 kb)
Online Resource 3 (PPT 72 kb)
392_2012_469_MOESM4_ESM.ppt (54 kb)
Online Resource 4 (PPT 57 kb)
392_2012_469_MOESM5_ESM.ppt (68 kb)
Online Resource 5 (PPT 64 kb)

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • M. Mueller
    • 1
  • S. Celik
    • 1
  • M. Biener
    • 1
  • M. Vafaie
    • 1
  • K. Schwoebel
    • 1
  • K. C. Wollert
    • 2
  • J. L. Januzzi
    • 3
  • H. A. Katus
    • 1
  • E. Giannitsis
    • 1
  1. 1.Medizinische Klinik, Abteilung für Innere Medizin IIIUniversitätsklinikum HeidelbergHeidelbergGermany
  2. 2.Klinik für Kardiologie und AngiologieMedizinische Hochschule HannoverHannoverGermany
  3. 3.Cardiology DivisionMassachusetts General HospitalBostonUSA

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