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Clinical Research in Cardiology

, Volume 101, Issue 7, pp 585–591 | Cite as

The new oral adenosine A1 receptor agonist capadenoson in male patients with stable angina

  • Michal TenderaEmail author
  • Ewa Gaszewska-Żurek
  • Zofia Parma
  • Piotr Ponikowski
  • Ewa Jankowska
  • Kalina Kawecka-Jaszcz
  • Danuta Czarnecka
  • Maria Krzemińska-Pakuła
  • Zbigniew Bednarkiewicz
  • Maciej Sosnowski
  • Michael Ochan Kilama
  • Rahul Agrawal
Original Paper

Abstract

Background

Anti-ischaemic effect of A1 adenosine receptor agonists was shown in animal and preclinical studies. The present proof-of-concept study aimed at evaluation of the efficacy and safety of a new adenosine A1 receptor agonist capadenoson in patients with stable angina.

Methods

This was a randomized, double-blind, placebo-controlled, single dose-escalating, multicenter trial comparing the effect of capadenoson at 1, 2.5, 5, 10, and 20 mg versus placebo. For each dose step patients were randomized to receive single doses of either capadenoson or matching placebo in a 5:1 ratio. The primary efficacy variable was the absolute difference in heart rate (HR) at maximum comparable level of workload between baseline and post dose exercise tolerance test at maximum concentration of capadenoson. Capadenoson effect on total exercise time and time to 1-mm ST-segment depression were also measured.

Results

Sixty-two male patients with stable angina were enrolled in the study. There was a consistent trend for HR reduction at comparable maximum work load in active treatment groups, with significant differences against placebo for 10 and 20 mg (HR reduction by 12.2 and 6.8 beats per min, p = 0.0002 and p = 0.032, respectively). A statistically significant trend (p = 0.0003) for a reduction in HR with increasing doses of capadenoson was shown. Increases in total exercise time and time to 1-mm ST-segment depression were also observed.

Conclusions

In patients with stable angina capadenoson lowers exercise HR at comparable maximum workload, which is associated with improved total exercise time and prolongation of time to ischaemia.

Keywords

Coronary artery disease Stable angina Capadenoson A1 receptor agonists Heart rate Exercise testing 

Notes

Acknowledgments

The study was funded by Bayer Schering Pharma, Wuppertal, Germany.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Michal Tendera
    • 1
    Email author
  • Ewa Gaszewska-Żurek
    • 1
  • Zofia Parma
    • 1
  • Piotr Ponikowski
    • 2
  • Ewa Jankowska
    • 2
  • Kalina Kawecka-Jaszcz
    • 3
  • Danuta Czarnecka
    • 3
  • Maria Krzemińska-Pakuła
    • 4
  • Zbigniew Bednarkiewicz
    • 4
  • Maciej Sosnowski
    • 1
  • Michael Ochan Kilama
    • 6
  • Rahul Agrawal
    • 5
  1. 1.Third Division of CardiologyMedical University of SilesiaKatowicePoland
  2. 2.Medical AcademyWroclawPoland
  3. 3.Collegium MedicumJagiellonian UniversityKrakowPoland
  4. 4.Medical UniversityLodzPoland
  5. 5.Bayer HealthCareWuppertalGermany
  6. 6.Bayer HealthCareMilanItaly

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