Clinical Research in Cardiology

, Volume 100, Issue 3, pp 249–251 | Cite as

Baroreflex activation as a novel therapeutic strategy for diastolic heart failure

  • Mathias C. Brandt
  • Navid Madershahian
  • Ralf Velden
  • Uta C. Hoppe
Letter to the Editors



CVRx Inc. provided financial support of the study and supported device implantation and programming.

Conflict of interest

M.C.B., N.M., and U.C.H. report no conflicts of interest. R.V. is an employee of CVRx Inc.


  1. 1.
    Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW (2009) 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 119:e391–e479CrossRefPubMedGoogle Scholar
  2. 2.
    Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C, Ptaszynska A (2008) Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 359:2456–2467CrossRefPubMedGoogle Scholar
  3. 3.
    Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J (2003) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 362:777–781CrossRefPubMedGoogle Scholar
  4. 4.
    Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 27:2338–2345CrossRefPubMedGoogle Scholar
  5. 5.
    Burns J, Sivananthan MU, Ball SG, Mackintosh AF, Mary DA, Greenwood JP (2007) Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension. Circulation 115:1999–2005CrossRefPubMedGoogle Scholar
  6. 6.
    Kaye DM, Lambert GW, Lefkovits J, Morris M, Jennings G, Esler MD (1994) Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. J Am Coll Cardiol 23:570–578CrossRefPubMedGoogle Scholar
  7. 7.
    Giannattasio C, Cattaneo BM, Seravalle G, Grassi G, Mancia G (1991) Left ventricular hypertrophy and the ‘cardiogenic reflex’ in man. J Hypertens Suppl 9:S43–S50CrossRefPubMedGoogle Scholar
  8. 8.
    Palatini P, Benetos A, Julius S (2006) Impact of increased heart rate on clinical outcomes in hypertension: implications for antihypertensive drug therapy. Drugs 66:133–144CrossRefPubMedGoogle Scholar
  9. 9.
    Eckberg DL, Fletcher GF, Braunwald E (1972) Mechanism of prolongation of the R-R interval with electrical stimulation of the carotid sinus nerves in man. Circ Res 30:131–138PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Mathias C. Brandt
    • 1
  • Navid Madershahian
    • 2
  • Ralf Velden
    • 3
  • Uta C. Hoppe
    • 1
  1. 1.Department of Internal Medicine IIIUniversity of CologneCologneGermany
  2. 2.Department of Cardiothoracic SurgeryUniversity of CologneCologneGermany
  3. 3.CVRx Inc.MinneapolisUSA

Personalised recommendations