Clinical Research in Cardiology

, Volume 100, Issue 1, pp 11–19 | Cite as

Heart rate reduction in cardiovascular disease and therapy

  • Jan-Christian Reil
  • Florian Custodis
  • Karl Swedberg
  • Michel Komajda
  • Jeffrey S. Borer
  • Ian Ford
  • Luigi Tavazzi
  • Ulrich Laufs
  • Michael Böhm


Heart rate influences myocardial oxygen demand, coronary blood flow, and myocardial function. Clinical and experimental studies support an association between elevated resting heart rate and a broad range of maladaptive effects on the function and structure of the cardiovascular system. Heart rate has been shown to be an important predictor of mortality in cardiovascular disorders such as coronary artery disease, myocardial infarction, and chronic heart failure. This review summarizes the specific influence of heart rate on vascular morphology and function as well as on myocardial lesions leading from early impact on vascular homeostasis to myocardial hemodynamics in chronic heart failure. Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy.


Heart rate Selective heart rate reduction Coronary heart disease Heart failure 


Conflicts of interest



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Jan-Christian Reil
    • 1
  • Florian Custodis
    • 1
  • Karl Swedberg
    • 2
  • Michel Komajda
    • 3
  • Jeffrey S. Borer
    • 4
  • Ian Ford
    • 5
  • Luigi Tavazzi
    • 6
  • Ulrich Laufs
    • 1
  • Michael Böhm
    • 1
  1. 1.Klinik für Innere Medizin III, Kardiologie, Angiologie und, Internistische IntensivmedizinUniversitätsklinikum des SaarlandesHomburg/SaarGermany
  2. 2.Department of Emergency and Cardiovascular Medicine, Sahlgrenska AcademyUniversity of GothenburgGöteborgSweden
  3. 3.Department of Cardiology, La Pitié-Salpétrière HospitalUniversity Pierre et Marie Curie Paris VIParisFrance
  4. 4.Division of Cardiovascular Medicine, The Howard Gilman Institute for Heart Valve DiseaseState University of New York Downstate Medical CenterBrooklynUSA
  5. 5.Robertson Centre for BiostatisticsUniversity of GlasgowGlasgowUK
  6. 6.GVM Care and ResearchMaria Cecilia HospitalCotignolaItaly

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