Clinical Research in Cardiology

, Volume 99, Issue 7, pp 419–427 | Cite as

Cardiac manifestation of the hypereosinophilic syndrome: new insights

  • T. Kleinfeldt
  • C. A. Nienaber
  • S. Kische
  • I. Akin
  • R. G. Turan
  • T. Körber
  • H. Schneider
  • H. Ince


Cardiac manifestation is the major cause of morbidity in patients with hypereosinophilic syndrome (HES). Clinical features range from heart failure to arterial embolism, which are caused by thickening of the endocardium and mural left ventricular thrombosis. Modern magnetic resonance imaging and echocardiography are able to detect fibrosis, eosinophilic infiltrate and thrombi to stage the fibrotic evolution of the disease. Treatment of HES involves standard medication for heart failure, anticoagulant therapy, immunosuppressive therapy and potentially surgical resection. The outcome of HES depends on both the progression of endocardial fibrosis and associated complications and the 5-year mortality is estimated at 30%.


Hypereosinophilic syndrome MRI Endocardiac fibrosis Immunosuppression Cardiomyopathy Gene Thrombus Echocardiography Biopsy Therapy 



The authors wish to acknowledge Princess Ogbogu, M.D., Douglas R. Rosing, M.D., and McDonald K. Horne, III, M.D. Allergy and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Written informed consent was obtained from the patient for publication of the accompanying images (Figs. 3a, b; 4a, b). A copy of the written consent is available for review by the Editor-in-Chief of this journal. The authors wish also to acknowledge Korczyk D et al. for Fig. 1a, b and Yeon Joo Jeong for Fig. 5a–c.

Conflict of interest statement



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • T. Kleinfeldt
    • 1
  • C. A. Nienaber
    • 1
  • S. Kische
    • 1
  • I. Akin
    • 1
  • R. G. Turan
    • 1
  • T. Körber
    • 1
  • H. Schneider
    • 1
  • H. Ince
    • 1
  1. 1.Medizinische Klinik I-KardiologieUniversity of RostockRostockGermany

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