Hotline sessions presented at the American College of Cardiology Congress 2009
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- Maier, L.S., Baumhäkel, M. & Böhm, M. Clin Res Cardiol (2009) 98: 345. doi:10.1007/s00392-009-0023-3
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The article summarizes the results of clinical trials in the field of cardiovascular medicine, which were presented during the Hotline Sessions at the annual meeting of the American College of Cardiology in Orlando, USA, from 28th March to 31st March 2009. The data were presented by leading experts in the field with relevant positions within the trials. Unpublished reports should be considered as preliminary data as the analysis may change in the final publications. The summaries presented in the manuscript were generated from the oral presentations and provide the readers with the comprehensive information on the results of the latest clinical trials in cardiovascular medicine.
KeywordsNAPLES II ARMYDA-RECAPTURE ABOARD OMEGA REVIVAL-3 EARLY-ACS TIPS ENCORE AURORA JUPITER STICH FIX-HF-5 Pre-RELAX-AHF PRIMA HORIZONS-AMI EPROTIROME Heinz Nixdorf recall study ACTIVE-A REVERSE Hypoxia-inducible factor-1α ADMIRE-HF
NAPLES II (novel approaches for preventing or limiting event study impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction)
The purpose of the NAPLES II study was to assess whether a single, high (80 mg), loading (within 24 h) dose of atorvastatin is effective in preventing elevation of biomarkers of myocardial infarction (MI) following elective coronary stent implantation. Periprocedural MI was defined as an elevation of CKMB ≥3-fold of the upper limit of normal (non-Q wave MI) or CKMB ≥2-fold of the upper limit with new significant Q waves in ≥2 contiguous leads (Q wave MI) within 12 h after intervention. It was a prospective, randomized, double-arm, two-center clinical study in Italy. Altogether, 668 patients were randomized with 338 patients being assigned to the treatment arm, if they were not treated with a statin previously (mean LDL similar in both groups 126–129 mg/dl). The results showed that atorvastatin reduced the incidence of periprocedural non-Q wave MI in elective PCI. This cardioprotective effect seems to be more pronounced in patients with high CRP level at baseline. Together these results suggest that the beneficial effects of atorvastatin may result from pleiotropic anti-inflammatory effects.
ARMYDA-RECAPTURE (atorvastatin for reduction of myocardial damage during angioplasty)
ABOARD (angioplasty to blunt the rise of troponin in acute coronary syndromes randomized for an immediate or delayed intervention)
The ABOARD study was a multicenter randomized trial to investigate whether immediate intervention (primary PCI strategy) is superior to delayed intervention (next day strategy) in patients with moderate to high-risk (TIMI score ≥3) in 352 patients with NSTEMI-ACS. All patients were on optimal medical therapy with high percentages of aspirin, clopidogrel, heparin, ACE-inhibitors, β-blockers, statins. 65% of the patients in both groups additionally received abciximab. The time to catheterization (radial access in 84% of the patients) was ~1 h for the immediate group (n = 175) and ~20 h (n = 177) for the delayed group. With respect to clinical endpoints (e.g. MI, death) as well as with respect to surrogate parameters (e.g. troponin, CK-MB) there was no difference between both groups.
OMEGA (randomized trial of omega-3 fatty acids on top of modern therapy after acute myocardial infarction: the OMEGA-trial)
Omega-3 fatty acids were recommended after myocardial infarction . In this trial, 1 g omega-3 fatty acids where tested versus placebo (olive oil) on top of optimal medical therapy. The primary endpoint was sudden cardiac death. More than 3,800 patients 3–14 days after acute myocardial infarction (STEMI or NSTEMI) were included. A sudden cardiac death rate of 3.5% was assumed which may have been the reason that no differences were found between both groups having only 1.5% sudden cardiac death on average. However, even in the secondary endpoints (total death, reinfarction, stroke, progression of coronary artery disease, arrhythmic events) no changes were found. In contrast to the GISSI-HF findings (in patients with chronic heart failure) after 4 years of following-up the patients (published last year) 1-year follow-up may not have been enough to find differences between treatment groups in the present study investigating omega-3 fatty acids in patients with MI.
REVIVAL-3 (prospective, randomized, double-blind, placebo-controlled trial of erythropoietin in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention)
The objective of this study was to assess the effect of high-dose erythropoietin in patients with acute ST-elevation myocardial infarction and EF < 50% treated with primary PCI. 138 patients were assigned to two groups. The verum group received erythropoietin beta (3.3 × 104 U) at the time of balloon inflation, and after 24 as well as 48 h. There was no difference in the primary end point of left ventricular EF after 6 months between both groups. Also infarct size was not reduced. Most disappointingly, there was even a trend towards a higher risk of adverse clinical events (MACCE at 6 months), which should be taken into account before planning future investigations with this drug in patients with acute MI.
EARLY-ACS (early glycoprotein IIb/IIIa inhibition in non-ST-segment elevation acute coronary syndrome: a randomized, double-blind, placebo-controlled trial evaluating the clinical benefits of early front-loaded eptifibatide in the treatment of patients with non-ST-segment elevation acute coronary syndromes)
The goal of the study was to compare the effect of two strategies for eptifibatide administration in high-risk NSTE ACS patients managed with an invasive diagnostic assessment. The first strategy was a routine, early administration of eptifibatide to all patients shortly after presentation. The second strategy consisted of a delayed, provisional eptifibatide administration at the physician’s discretion after coronary angiography and prior to PCI. In all five continents >9,400 patients were assigned to this study. Early eptifibatide compared with delayed, provisional eptifibatide at PCI did not significantly reduce the primary composite of death, MI, recurrent ischemia requiring urgent revascularization, or thrombotic bailout at 96 h, but resulted in a trend toward reduction in death or MI at 30 days with no difference in 30-day mortality. Also, it resulted in higher rates of non-life-threatening bleeding and transfusions. Although the results of EARLY-ACS do not support a strategy of routine early eptifibatide use in high-risk NSTE ACS patients managed with an invasive strategy it is possible that a subgroup of patients who have a low risk of bleeding may be considered for early eptifibatide use .
TIPS (The Indian Polycap Study)
This randomized and double blind study investigated the effects of a polypill (Polycap) containing three blood pressure lowering drugs at low doses (thiazide 12.5 mg, atenolol 50 mg, ramipril 5 mg) with and without aspirin (100 mg) and simvastatin (20 mg). 400 patients with at least one cardiovascular risk factor in India were randomized to this group and 200 patients were assigned to eight other groups (1: aspirin, 2: thiazide, 3: thiazide + ramipril, 4: thiazide + atenolol, 5: ramipril + atenolol, 6: thiazide + ramipril + atenolol, 7: thiazide + ramipril + atenolol + aspirin, 8: simvastatin). Mean heart rate before the study was 80 bpm, systolic RR was 134 mmHg, and LDL was 3.0 mmol/l. After 12 weeks the results clearly showed that RR was lowered linearly when increasing the number of RR lowering drugs up to 7 mmHg, heart rate was reduced in all atenolol groups by 7 bpm. LDL was reduced similarly in the simvastatin formulations compared to the Polycap group between 0.7 and 0.83 mmol/l. It was estimated that the combination of all effects tested using the Polycap could reduce the relative risk for CHD by 62% and for stroke by 48%. It is concluded by the authors that in patients with average risk factor levels, the Polycap consisting of five different cardiovascular drugs has similar effects than the combination of each of the single drugs, it is well tolerated, and most importantly it may potentially reduce CVD risk by about half .
ENCORE (cardiovascular benefits associated with the DASH diet alone and in combination with exercise and weight reduction in men and women with high blood pressure)
Cardiovascular risk is influenced by changes in habits . The objective of this study was to examine the effects of (1) the DASH diet (1,962 kcal) and (2) the DASH diet plus exercise and weight loss (1,648 kcal) on blood pressure in overweight patients with high blood pressure. About 150 patients were included in the study. The study showed that the DASH diet alone resulted in significant blood pressure lowering (by 11 mmHg systolic blood pressure). However, exercise and weight loss in addition to the DASH diet resulted in an incremental decrease in blood pressure (by 16 mmHg systolic blood pressure), as well as greater improvements in cardiovascular manifestations of high blood pressure.
Home health monitoring reduces cardiovascular disease risk in medically underserved communities
The objective was to lower cardiovascular disease risk in urban and rural underserved communities and to compare a nurse management program (four visits in 1 year) versus nurse management plus weekly reporting of CVD risk factors via telemedicine. Almost 400 subjects without CVD but an increased were included and divided into the two arms. The primary end point was a reduction in 5% or greater in CVD risk at 1 year. Although this endpoint was not reached, at least blood pressure was reduced to a greater extent in the telemedicine group. As compared to Caucasians, African Americans showed less blood pressure and lipid control. The authors concluded that a nurse management program can reduce CVD risk in medically underserved communities. Telemedicine provides additional benefit for blood pressure management. Male and female subjects achieved similar improvements in blood pressure and lipids. White subjects achieve lower blood pressure and lipid values compared to African Americans.
AURORA (effect of rosuvastatin versus placebo on cardiovascular outcomes in patients with end-stage renal disease on hemodialysis)
This study showed that initiation of rosuvastatin did not cause a reduction in the combined endpoint of CV death, MI or stroke, even though LDL-C was significantly reduced and even a minor reduction in Hs-CRP occurred. Rosuvastatin treatment was well tolerated. The authors concluded that a lack of CV benefit with statins in both AURORA and 4D suggests that CVD in hemodialysis patients is different compared with that in a non-renal population. There is a need for further research and analysis of data and to explore new approaches and treatment strategies for reduction of the high risk of CVD in hemodialysis patients as stated in the published article by the authors the same day .
JUPITER (CRP reduction, LDL reduction, and cardiovascular event rates after initiation of rosuvastatin)
Hazard ratios for cardiovascular events related to LDL-cholesterol and hs-CRP levels
LDL cholesterol (mg/dl) and hs-CRP (mg/l) levels
Hazard ratio (95% CI)
hs-CRP levels <2 mg/l
≥70 and ≥2
≥70 and <2
<70 and ≥2
<70 and 2
≥70 or ≥2
hs-CRP levels <1 mg/l
≥70 and ≥1
≥70 and <1
<70 and ≥1
<70 and <1
≥70 or ≥1
STICH: surgical treatment for ischemic heart failure trial—CABG versus CABG + SVR – hypothesis 2
FIX-HF-5: multicenter randomized controlled trials of cardiac contractility modulation in patients with advanced heart failure
Patients with advanced heart failure with a functional NYHA-class III-IV and a EF ≤ 35% were enrolled in the FIX-HF-5-trial to evaluate the influence of an implanted electrical cardiac contractility modulation (CCM) device on anaerobic threshold and quality of life. The signals of the CCM-device are non-excitatory delivered during the absolute refractory period only to improve cardiac contractility . The safety endpoint of mortality and hospitalization after 12 months was not different in both groups (medical treatment: 213 patients; medical treatment +CCM: 215 patients). Moreover the primary efficacy endpoint (anearobic threshold, AT) could not be improved significantly by CCM compared to medical treatment alone. However, quality of life, NYHA-classification and peak VO2 significantly increased in patients with CCM compared to medical treatment alone. Moreover, a subgroup-analysis revealed a significant benefit regarding the primary endpoint of AT in patients with an EF ≤ 25%, but as a major limitation, there was no blinding in this trial.
Pre-RELAX-AHF-Study: relaxin, a novel treatment for acute heart failure
Relaxin is a natural human peptide, mediating vasoregulatory effects especially during pregnancy . In this trials 234 patients with acute heart failure (dyspnoea, congestion on chest radiograph, and increased brain natriuretic peptide (BNP) with a normal blood pressure (>125 mmHg) were assigned to placebo (n = 62) or relaxin 10 μg/kg (n = 40), 30 μg/kg (n = 43), 100 μg/kg (n = 39), or 250 μg/kg (n = 50) per day. Mean time of enrollment was 6 h with a treatment period of 48 h. Blood pressure reduction was not significantly different from placebo in all relaxin treatment groups in patients with a systolic blood pressure below 140 mmHg at baseline. In patients with an initial systolic blood pressure above 140 mmHg, there was a significant reduction by relaxin. Clinical endpoints as dyspnea and reduction of edema improved with relaxin 30 μg/kg compared to placebo. Length of hospital stay was reduced in relaxin-treated patients (10.2 ± 6.1 days) compared to placebo (12.0 ± 7.3 days). Cardiovascular death and days alive out of hospital were significantly reduced for 30 μg/kg at days 60 and 180. There were no differences of adverse or serious adverse events in all treatment groups. Moreover, renal function was not affected by relaxin treatment. These results demonstrate the safety of relaxin-treatment in acute heart failure and are the basis for further clinical trials .
PRIMA-study: can pro-brain natriuretic peptide guided therapy of heart failure improve heart failure morbidity and mortality?
Patients with chronic heart failure were managed with a fixed NT-proBNP level in most trials, but many patients fail to reach this target . The PRIMA-study investigated, whether individually management of chronic heart failure by pro-BNP levels improves morbidity and mortality. Inclusion criteria were admission to hospital with symptomatic heart failure and an increased NT-proBNP of at least 200 pmol/l. The NT-proBNP guided group (n = 174) was managed individually with regard to the lowest NT-proBNP level in the first 2 weeks after beginning of treatment of acute HF, whereas the clinical judgement group (n = 171) was not. Within a median FU of 702 days, there was no statistical difference either in the primary endpoint (days alive outside hospital, 685 days for BNP group, 664 days for control) or in cardiovascular mortality or hospitalizations. Total mortality was 26.5% in the BNP-guided patients and 33.3% in clinically guided patients. However, NT-proBNP guided management resulted in significantly more frequent start or increase of heart failure medications.
HORIZONS-AMI-trial: predictors of stent thrombosis after primary angioplasty in acute myocardial infarction
The new analysis of the HORIZONS-AMI trial evaluated risk factors for late stent thrombosis (up to 1 year) after primary PCI in ST-elevation myocardial infarction in 3,202 patients treated with stenting . Stent thrombosis occurred in 3.3% of patients (0.9% acute, 1.6% subacute, 1.0% late). There was no difference of rate of stent thrombosis in patients treated with a drug-eluting or a bare-metal stent respectively. Risk factors for late stent thrombosis were insulin treated diabetes, ongoing smoking, high number of stents, treatment of ulcerated lesions and total occlusion of the coronary artery responsible for MI. Moreover, there was no statistically different rate of stent-thrombosis in patients receiving bivalirudin (3.6%) compared to heparin and GP IIb/IIIa-inhibitor (3.2%). High-dose clopidogrel (600 mg) was found to be protective, especially for subacute stent-thrombosis.
JUPITER: a randomized trial of rosuvastatin in the prevention of venous thromboembolism
Eprotirome as a novel and physiological approach to CVD risk reduction: beneficial effects on lipoprotein levels when added to statin therapy
Lipid metabolism regulated by thyroid hormones takes place in the liver. Eprotirome is a liver-selective thyroid receptor agonist and was evaluated for safety and lipid-lowering effects combined with a statin in 189 patients with hypercholesterolemia . All lipid markers, especially LDL (−25%), triglycerides and lipoprotein(a) (both −30 to −40%) were significantly reduced with eprotirome. Non-high-density lipoproteins and apolipoprotein B were reduced by 25%. Thus the substance might be beneficial in patients who need further LDL-reduction beyond statin treatment or with a mixed hypercholesterolemia respectively. Within the trials, eprotirome was safe and function restricted to the liver.
Signs of subclinical coronary atherosclerosis measured as coronary artery calcification improve risk prediction of hard events beyond traditional risk factors in an unselected general population: the Heinz Nixdorf recall study 5-year outcome data
The prospective cohort-study evaluated more than 4,800 patients without known coronary artery disease for predictors and signs of subclinical atherosclerosis. The 5-year outcome data were herein presented with the coronary artery calcium score (measured by electron-beam tomography) being a better predictor of cardiovascular disease compared to classic risk factors. However, the risk prediction was more valid in men than in women and is suggested to improve risk prediction of patients, especially with intermediate risk.
Treatment of intermittent claudication with hypoxia-inducible factor-1α
Two hundred and eighty-nine patients with claudication and PAD in both legs (67 years, mean ABI 0.6 in the index leg) were randomized to three different doses of hypoxia-inducible factor (HIF)-1α or placebo administered to the thigh and calf muscle. After 3 and 6 months follow-up neither peak walking time, walking distance, claudication onset time nor ABI could be improved. Thus, gene therapy with HIF-1α offers no benefit in for PAD.
ACTIVE A: clopidogrel plus aspirin versus aspirin alone for prevention of vascular events in patients with atrial fibrillation at high risk of stroke
Cardiac resynchronization therapy prevents disease progression in NYHA class I-II heart failure patients: 24 months results from the european cohort of the REVERSE trial
The results of this trial represent the data of the 262 European participants of the REVERSE-trial with 180 patients in the verum-group with enabled CRT function compared to 82 patients with disabled device function. After a follow-up of 24 months, patients with enabled devices had a reduced LVESV (69.7 vs. 94.5 ml/m2, p < 0.0001) and LVEDV (103 vs. 132 ml/m2, p < 0.0001). In contrast to the 12 months follow-up results, clinical worsening was significantly less frequent in CRT-patients (19%) compared to non-CRT patients (34%, p < 0.01). Moreover, there was a 62% RRR in time to first hospitalization or death in patients with enabled CRT-device. However, the primary end-point composite of all-cause mortality, heart-failure hospitalizations, crossover due to worsening heart failure, NYHA class, and the patient global assessment was not significantly different in both treatment groups. This is most likely to the missing change of functional parameters, including the Minnesota Living with Heart Failure Questionnaire, the 6-min walk test, and NYHA class.
ADMIRE-HF-trial: prognostic significance of 123I-mIBG myocardial scintigraphy in heart failure patients
123I meta-iodobenzylguanidine is a physiologic analogue of norepinephrine, taken up into sympathetic nerves. Due to prior single centre trials, a lower uptake of 123I mIBG in patients with heart failure is associated with a poor outcome. In this trial, 964 patients with chronic heart failure in a functional NYHA-class II-III were quantified regarding cardiac uptake of the tracer. The heart/mediastinum-ratio (H/M) was determined with a cut-off of 1.6 for a high-uptake. After a follow-up for a maximum of 2 years, the composite endpoint of NYHA-class progression, potentially life-threatening arrhythmic event and cardiac death was significantly more frequent in patients with a low uptake (37%) of the tracer (high-uptake 15%). Moreover, there were 51 cardiac deaths in the low-uptake and only two cardiac deaths in the high-uptake group with a negative predictive value of 98.8% for cardiac death in patients with a high uptake. Thus, myocardial scintigraphy might be a useful tool in risk stratification of patients with chronic heart failure.