Hormonal status modulates circulating endothelial progenitor cells
- First Online:
- 83 Downloads
Endothelial progenitor cells (EPCs) may have an important role in vascular homeostasis and repair.
We examined the level of circulating EPCs in pre- (n = 22; mean age 28.7 years), and postmenopausal healthy females without (n = 30; mean age 61.6 years) or under current hormone replacement therapy (HRT) (n = 19; mean age 59.8 years).
Premenopausal females had the highest level of circulating EPCs (0.147 ± 0.076‰ of polymorphnuclear cells). The level of EPCs was lowest in postmenopausal females (0.094 ± 0.058‰), and increased significantly with HRT on average by 25.5%. In addition, the proliferative capacity of circulating EPCs was assessed under cell culture conditions. This capacity was significantly increased in EPCs isolated from postmenopausal subjects under current HRT as compared to corresponding samples obtained from postmenopausal females without HRT.
This observation is in line with the hypothesis that the hormonal status in females modulates the cardiovascular risk and that circulating EPCs could be involved in this phenomenon.
Key wordsendothelial progenitor cells cardiovascular risk endothelial function hormone replacement therapy estradiol
Unable to display preview. Download preview PDF.
- 4.Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW (2003) Estrogen- mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells conbtributes to reendothelialization after arterial injury. Circulation 108:3115–3121PubMedCrossRefGoogle Scholar
- 17.Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, Losordo DW, Isner JM, Asahara T (2003) Stromal cell-derived factor-1 on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107:1322–1328PubMedCrossRefGoogle Scholar
- 18.Schmidt-Lucke C, Rössig L, Fichtlscherer S, Vasa M,. Britten M, Kämper U, Dimmeler S, Zeiher A (2005) Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events. Proof of concept for the clinical importance of endogenous vascular repair. Circulation 111:2981–2987PubMedCrossRefGoogle Scholar