Clinical Research in Cardiology

, Volume 96, Issue 2, pp 70–76 | Cite as

Comparison of the slow-release polymerbased paclitaxel-eluting Taxus-Express stent with the bare-metal Express stent for saphenous vein graft interventions

  • Jochen Wöhrle
  • Thorsten Nusser
  • Hans A. Kestler
  • Matthias Kochs
  • Vinzenz Hombach
ORIGINAL PAPER

Summary

Background

The paclitaxel-eluting Taxus-Express stent is superior regarding angiographic and clinical outcome compared with its bare-metal platform for lesions in native coronary arteries. We studied the potential impact of the Taxus-Express stent in comparison with its bare-metal counterpart for treatment of lesions in saphenous vein grafts (SVGs). Furthermore, a metaanalysis was performed regarding use of drug-eluting (DES) vs bare-metal stents (BMS) in SVG lesions.

Methods

We analyzed 13 consecutive patients who underwent percutaneous revascularization in SVG lesions using the slowrelease, paclitaxel-eluting Taxus- Express stent. These lesions were balanced with 26 patients with SVG lesions treated with the baremetal Express stent (BMS) in the preceding period. Angiographic follow-up was performed after 6 months, clinical follow-up after 6 and 12 months.

Results

There were no statistically significant differences regarding clinical, procedural and angiographic parameters pre and post intervention. Binary restenoses occurred significantly less in the Taxus group compared with the BMS group (0% vs 34.6%; p=0.016). This translated into a significantly lower occurrence of major adverse cardiac events (death, Q-wave myocardial infarction, repeat target vessel revascularization) in the Taxus group compared with the BMS group at the 6-month (0% vs 26.9%, p=0.039) and 12-month follow-up (7.7% vs 38.5%, p=0.045). Multivariate predictors for freedom of binary restenosis were the reference diameter pre intervention and treatment with Taxus stents. Metaanalysis including 280 DES and 256 BMS patients revealed an odds ratio of 0.34 (95% confidence interval 0.21–0.54) for MACE and 0.26 (95% confidence interval 0.16–0.44) for target vessel revascularizations, both favoring DES.

Conclusions

We conclude that the use of the slow-release Taxus-Express stent has the potential to be superior regarding angiographic and clinical outcome compared with its bare-metal counterpart for treatment of SVG lesions within a 12-month follow-up. A large, randomized trial including a long follow-up period is now required to prove the results of the metaanalysis.

Key words

Saphenous vein graft drug-eluting stent restenosis paclitaxel quantitative coronary analysis 

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Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • Jochen Wöhrle
    • 1
  • Thorsten Nusser
    • 1
  • Hans A. Kestler
    • 2
  • Matthias Kochs
    • 1
  • Vinzenz Hombach
    • 1
  1. 1.Department of Internal Medicine IIUniversity of UlmUlmGermany
  2. 2.BioinformaticsUniversity of UlmUlmGermany

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